Resistance and targeting

Xem 1-20 trên 104 kết quả Resistance and targeting
  • In 1989, Hodge et al. published two papers in the Journal of Urology (Hodge et al., 1989a and 1989b). The first paper described directed transrectal prostate biopsies of palpable abnormalities, 90% of which had corresponding hypoechoic lesions on ultrasound (Hodge 1989a). Additional biopsies were also taken of isoechoic areas of the peripheral and central zones. These biopsies were not systematic and they were found to be positive in 66% of cases. The second article was a landmark paper which marked the start of the modern era of prostate needle biopsy (Hodge et al., 1989b).

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  • Since all of these flavors are present in beer, it is important that beer judges completely coat the inside of their mouths with beer when evaluating it and that the beer be swallowed. As is true for the scent receptors in the nose, different people have different densities of taste buds and, thus, have different sensitivities to various flavors. Also, taste buds can be damaged (e.g., being burnt by hot food or through exposure to irritants like spicy foods, smoking, or other chemicals), so a judge’s sensitivity may be diminished until tastebuds can regenerate (about 10 days).

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  • The program has reached providers in over 33 states through train-the-trainer sessions and conferences. Much of the information provided in this report was gained or substantiated through extensive interaction with providers around the United States and internationally. Ultimately through a large evaluation component, impact of the training on preparedness, creation of plans, and staff will be reported.

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  • During the second half of the 1990s, mortgage underwriting increasingly incorporated credit scores and other automated evaluations of credit histories. As of 1999, approximately 60 to 70 percent of all mortgages were underwritten using an automated evaluation of credit, and the share was rising2 . The automated quantification of the information in credit reports has not simply been used to decide whether or not to extend credit, but has also been used to set prices and terms for mortgages and other consumer credit.

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  • Because of improvements in air quality, such deadly air pollution episodes are rare in U.S. cities. Modern research methods have shown, however, that deaths and serious illnesses from common air pollutants still occur at levels well below regulatory standards, and at current levels in New York and most large cities. Local actions to further reduce air pollution will mean changes in policies and behaviors, and will require significant investments in new vehicles and other equipment.

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  • Another important change can be traced to the 1960s and 1970s, when some producers and dealers began testing the possibility of selling rough diamonds through alternative channels instead of the traditional practice of selling through the unified sales channel of De Beers’ CSO (see.Figure.8). In the 1990s major producers began breaking away from the CSO (later transformed into the Diamond Trading Company, or DTC) to start selling their diamonds independently on the global market.

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  • There are also environmental trends that threaten to radically alter the planet, that threaten the lives of many species upon it. including the human species. Each year another 6 million hectares of productive dryland turns into worthless desert. Over three decades, this would amount to an area roughly as large as Saudi Arabia. More than 11 million hectares of forests are destroyed yearly, and this, over three decades, would equal an area about the size of India. Much of this forest is converted to low-grade farmland unable to support the farmers who settle it.

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  • Given the unprecedented—by recent standards—financial crisis that has devastated the world financial system and extended its reach into a number of other sectors, political risk insurance has become even more relevant. At the same time, questions remain as to whether PRI really covers those risks that investors need covered the most.

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  • The data allow us to focus on eight basic questions about the microfinance “industry”: Who are the lenders? How widespread is profitability? Are loans in fact repaid at the high rates advertised? Who are the customers? Why are interest rates so high? Are profits high enough to attract profit-maximizing investors? How important are subsidies? How robust are the financial data? The answers then take us back to reconsider the initial questions of subsidy, profit, and social impact in microfinance. Who are the lenders? The clash between Grameen Bank and...

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  • Just having an assumptive attitude and saying, “Great, welcome to the club” or “That’s the option most of our members choose” makes the guest think that it is what everybody does and they will simply figure that this must be how it works. Too many times, a salesperson will accidentally give the prospect an opportunity to haggle by not closing the deal right away when they had the chance. You can even make the choice for them many times. If they already said that price is a concern, when you show them the options, you can automatically...

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  • The definition of research priorities for the European food sector will necessarily focus on the single stages of the food chain, from raw material production through post harvesting, processing, post-processing, and distribution to the end consumer. Therefore it’s essential to have at the beginning an idea of the current state of the art of the sector and the main developments along the food chain at the moment. During the next 10 years, the European food sector will continue its since long ongoing structural transition.

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  • Our paper focuses on accounting professionals in Romania as being a significant element when considering a national accounting system that went through complex accounting reforms of more than two decades. Since accounting policy represents an area of social and economic policy we must also consider the five decades of communist regime leaving their fingerprint on the Romanian society. It is our objective to capture the perception of the Romanian accounting profession that actually witnessed all these processes of transformation.

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  • At stage one, the government contracting agency (PJPK) will form a procurement committee as well as conducting market sounding to get feedback from the private sector on the quality and attractiveness of the project. As part of the feasibility study, the committee will prepare a Self Assessed Price (HPS) and gather prequalifications documents and procurement documents.

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  • Noise is a key concern for people living near transport infrastructure, and can be damaging to both health and general well-being. Although train noise is already much less intrusive than noise from air and road traffi c (see Figure 5), the railway sector wants to reduce noise even further, especially that caused by freight trains. Many of these trains still use loud cast-iron brake blocks, unlike passenger trains, most of which use disc brakes.

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  • So then you may think that the population-poverty-resource nexus would be a focus of attention among development economists. If so, you would be wrong. Even in studies on the semi-arid regions of sub-Saharan Africa and the Indian sub-continent (poverty-ridden land masses, inhabited by some 2 billion people and experiencing the largest additions ever known to their population; Tables 1-2), the nexus is largely absent. For example,Birdsall (1988),Kelley (1988) and Schultz (1988) are authoritative surveys by economic demographers on population growth in poor countries.

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  • We first highlight psychological and psychosocial issues associated with breast can- cer, and then underscore specific psychosocial variables that may play a role in the dis- ease. Further, we bring to light the current literature of psychosocial interventions for patients with cancer. We then introduce preliminary research from an on-going study funded by the National Cancer Institute (NCI). This is a pilot study intended to explore psychosocial factors and quality of life, preparatory to embarking on a larger scale, long- term study.

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  • In addition, we only provide data at maturities where we think the curve can be fitted so that it is stable and meaningful. Instability arises when small movements in bond prices lead to unrealistically large moves in the estimated yield curves, essentially because there is not enough information from observed prices at a given maturity to allow us to fit that segment of the curve. This is usually a problem at short maturities where we require more information because we expect the short end of the yield curve to exhibit the greatest amount of structure.

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  • Baumgarten expresses that aesthetics (beauty) is a harmony of expression, structure and content. Probably a statement which is identical to what an artist expresses when saying that a work must have a clear leading feature: a main idea (theme), a structure (structural principles) and a content (which provide a work’s richness and evidences power and life) [5, p.74]. Our methodical approach to formgiving rooted in aesthetics is based on this leading feature, although the contents of the three components are only partially resolved in relation to the design of artefacts.

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  • The evolution of India’s automotive industry is identified to have occurred in four phases. In the first (1947-1965) and second phase (1966-1979), the important policies identified were related to protection, indigenisation and regulation of the industry. On the one hand, these policies helped India to build an indigenous automotive industry, while on the other it led to unsatisfactory industry performance. In the third phase (1980-1990), the single most important policy identified was the one with regard to relaxation in the means of technology acquisition.

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  • In this paper, participants in the Translational Medicine task force of the World Wide Web Consortium’s Health Care and Life Sciences Interest Group (W3C HCLSIG) present the Translational Medicine Ontology (TMO) and the Translational Medicine Knowledge Base (TMKB). The TMKB consists of the TMO, mappings to other terminologies and ontologies, and data in RDF format spanning discovery research and drug development, which are of therapeutic relevance to clinical research and clinical practice.

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