Mutant template human telomerase RNAs (MT-hTers) have been shown
to induce apoptosis in various cancer cells with high telomerase activity.
However, the mechanism by which MT-hTers inhibit the growth of cancer
cells and their effects on normal cells remain unknown.
Telomerase is a specialized reverse transcriptase responsible for synthesizing telomeric DNA at the ends of chromosomes. Six subunits composing the telomerase complex have been cloned: hTR (human telomerase RNA), TEP1 (telomerase-associated protein 1), hTERT (human telomerase reverse transcriptase), hsp90 (heat shock protein 90), p23, and dyskerin. In this study, we investigated the role of each the telomerase subunit on the activity of telomerase.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution...