In this series of four minireviews the field of scaffold proteins and proteins
of similar molecular⁄cellular functions is overviewed. By binding and bring-ing into proximity two or more signaling proteins, these proteins direct the
flow of information in the cell by activating, coordinating and regulating
signaling events in regulatory networks.
Having explored and mapped our planet's land masses, vast oceans and the space surrounding it, science is turning inward to the challenging and controversial mapping of the human genome, a collection of genes forming DNA. Each of our genes is a single instruction for the make-up of an individual being. The more we learn, the more we discover to explore - and the more controversy we release in the process.
Tuyển tập các báo cáo nghiên cứu khoa học ngành toán học được đăng trên tạp chí toán học quốc tế đề tài: Gelatin-layered and multi-sized porous beta-tricalcium phosphate for tissue engineering scaffold
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Gelatin-layered and multi-sized porous beta-tricalcium phosphate for tissue engineering scaffold
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Embryonic stem cells in scaffold-free threedimensional cell culture: osteogenic differentiation and bone generation
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Fibrin and poly(lactic-co-glycolic acid) hybrid scaffold promotes early chondrogenesis of articular chondrocytes: an in vitro study
Int J Adv Manuf Technol (2007) 34:496–515 DOI 10.1007/s00170-006-0628-x
A scaffolding architecture for conformal cooling design in rapid plastic injection moulding
Received: 4 August 2005 / Accepted: 25 March 2006 / Published online: 8 June 2006 # Springer-Verlag London Limited 2006
Abstract Cooling design of plastic injection mould is important because it not only affects part quality but also the injection moulding cycle time. Traditional injection mould cooling layout is based on a conventional machining process.
Mutations in the human Crumbs homologue 1 (CRB1) gene are a frequent
cause of various forms of retinitis pigmentosa. The CRB1–membrane-asso-ciated palmitoylated protein (MPP)5 protein complex is thought to organ-ize an intracellular protein scaffold in the retina that is involved in
maintenance of photoreceptor–Mu¨ller glia cell adhesion.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Quantitative ultrasound can assess the regeneration process of tissue-engineered cartilage using a complex between adherent bone marrow cells and a three-dimensional scaffold...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1
Human disc-large homolog (hDlg), also known as synapse-associated
protein 97, is a scaffold protein, a member of the membrane-associated
guanylate kinase family, implicated in neuronal synapses and epithelial–
epithelial cell junctions whose expression and function remains poorly char-acterized in most tissues, particularly in the vasculature.
Although much of the growing digital economy rests on the Internet and World Wide Web, which in turn rest on information technology standards, it is unclear how much longer the current momentum can be sustained absent new standards. To discover whether today’s standards processes are adequate, where they are taking
In recent years, classical antibody-based affinity reagents have been
challenged by novel types of binding proteins developed by combinatorial
protein engineering principles. One of these classes of binding proteins of
non-Ig origin are the so-called affibody binding proteins, functionally
selected from libraries of a small (6 kDa), non-cysteine three-helix bundle
domain used as a scaffold.
Nephrin is a signalling cell–cell adhesion protein of the Ig superfamily and
the first identified component of the slit diaphragm that forms the critical
and ultimate part of the glomerular ultrafiltration barrier. The extracellular
domains of the nephrin molecules form a network of homophilic and
heterophilic interactions building the structural scaffold of the slit dia-phragm between the podocyte foot processes.
The 23rd day of November, 1867, witnessed a strange and memorable scene in the great English city of
Manchester. Long ere the grey winter's morning struggled in through the crisp frosty air--long ere the first
gleam of the coming day dulled the glare of the flaming gas jets, the streets of the Lancashire capital were all
astir with bustling crowds, and the silence of the night was broken by the ceaseless footfalls and the voices of
One of the main advantages of this technique is that it can produce the scaffold with main
structural feature suitable for growth of the cell and subsequent tissue organization (Li &
Tuan, 2009; Liang et al., 2007; Leong et al., 2008). It can produce the ultra fine fibers with
special orientation, high aspect ratio, high surface area, and having control over pore
Signaling cascades, in addition to proteins with obvious signaling-relevant
activities (e.g. protein kinases or receptors), also employ dedicated ‘inactive’
proteins whose functions appear to be the organization of the former com-ponents into higher order complexes through protein–protein interactions.
The core function of signaling adaptors, anchors and scaffolds is the
recruitment of proteins into one macromolecular complex.
SR protein kinases (SRPKs) phosphorylate Ser⁄Arg dipeptide-containing
proteins that play crucial roles in a broad spectrum of basic cellular processes.
Phosphorylation by SRPKs constitutes a major way of regulating such cellu-lar mechanisms. In the past, we have shown that SRPK1a interacts with the
nuclear matrix protein scaffold attachment factor B1 (SAFB1) via its unique
N-terminal domain, which differentiates it from SRPK1.
Spinophilin, a neuronal scaffolding protein, is essential for synaptic trans-mission, and functions to target protein phosphatase-1 to distinct subcellu-lar locations in dendritic spines. It is vital for the regulation of dendritic
spine formation and motility, and functions by regulating glutamatergic
receptors and binding to filamentous actin.
Many of the fabrication techniques require use of organic solvents and high temperature.
The residues that remains after completion of process can damage cells and nearby tissues.
This may also denature the biologically active molecules incorporated within the scaffolds.
The gas foaming scaffold fabrication techniques does not require the utilization of organic
solvents and high temperature.
This technique uses high pressure carbon dioxide gas for the fabrication of highly porous