Calorimetry, as a technique for thermal analysis, has a wide range of applications which are not only limited to studying the thermal characterisation (e.g. melting temperature, denaturation temperature and enthalpy change) of small and large drug molecules, but are also extended to characterisation of fuel, metals and oils.
Under the umbrella of Rapid-X (Udroiu & Ivan, 2008) there are some specific terms such as:
Rapid Product Development (RPD), Rapid Technology, Rapid Nanotechnology, Rapid
Prototyping (RP), Rapid Tooling (RT) and Rapid Manufacturing (RM). Additive
manufacturing (AM) is an important component of the rapid product development process.
Laser scanning technology has emerged as a research field in the science and
engineering arena. Laser scanning performs a procedure to detect a surface using laser
technology. A scanning device analyzes a real-world object to retrieve data on its
shape and its appearance. The collected data can then be used to construct a digital
three-dimensional model. The aim of the scanning is usually to create a point cloud on
an object surface.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Research Article Bayesian Hierarchical Model for Estimating Gene Expression Intensity Using Multiple Scanned Microarrays
In this paper we propose enhancing Web clients with
new security mechanisms that can not only prevent ex-
isting attacks, but are able to enforce all security policies
based on monitoring client behavior. In particular, our
new mechanisms support policies that range from disal-
lowing use of certain Web client features (e.g., IFRAMEs
or OBJECTs) to ﬁne-grained, application-speciﬁc invari-
ants such as taint-based policies that regulate the ﬂow of
credit-card information input by the user.
In order to determine the amino-terminal sequence
requirements for protein N-myristoylation, site-directed
mutagenesis of the N-terminal region was performed using
tumor necrosis factor (TNF) mutants as model substrate
proteins. Subsequently, the susceptibility of thesemutants to
protein N-myristoylation was evaluated by metabolic labe-ling in anin vitrotranslation systemusing rabbit reticulocyte
lysate. A TNF mutant having the sequence MGAAAAA
AAA at its N-terminus was used as the starting sequence
to identify elements critical for protein N-myristoylation....
As an example of how queries are executed, consider the query shown in Figure 5. In Figure 6, the processes
used to execute the query are shown along with the ﬂow of data between the various processes for a Gamma
conﬁguration consisting of two processors with disks and two processors without disks. Since the two input rela-
tions A and B are partitioned across the disks attached to processors P1 and P2, selection and scan operators are ini-
tiated on both processors P1 and P2.
The stereolithographic (SL) process is performed on the equipment
shown in Figure 1. The movable platform on which the 3D model is
formed is initially immersed in a vat of liquid photopolymer resin to a
level just below its surface so that a thin layer of the resin covers it. The
SL equipment is located in a sealed chamber to prevent the escape of
fumes from the resin vat.
The resin changes from a liquid to a solid when exposed to the ultra-
violet (UV) light from a low-power, highly focused laser.
The goal of our research is to develop an autonomous robot for subsurface mapping. We are motivated by the growing need for mapping buried pipes, hazardous waste, landmines and other buried objects. Most of these are large scale mapping problems, and to manually construct subsurface maps in these cases would require a signiﬁcant amount of resources. Therefore, automating the subsurface mapping process is an important factor in alleviating these problems. To achieve our goal, we have developed a robotic system that can autonomously gather and process Ground Penetrating Radar (GPR) data.
This report covers in considerable detail the legal as well as institutional struc-
tures of the Serbian bond market, and compares these to the evolution of the recent-
ly developed bond markets in the Czech Republic, Hungary, Poland, and Slovakia.
The core of the study is a technical section on the estimation of the bond yield curve
in Serbia using the Nelson-Siegel Model, followed by an illustration of how parame-
ter estimates can be utilized to forecast the term structure. This analysis was con-
strained by limited data availability on the over-the-counter market.
We used parameter scanning to emulate changes to the
limitingrate for steps inafittedmodel of glucose-derepressed
yeast glycolysis. Three flux-control regimes were observed,
two of which were under the dominant control of hexose
transport, in accordance with various experimental studies
The uptake by mammalian cells of phosphorothioate oli-gonucleotides was compared with that of their respective
complexes or conjugates with cationic, cell-penetrating
model peptides of varying helix-forming propensity and
amphipathicity. An HPLC-based protocol for the synthesis
and purification of disulfide bridged conjugates in the 10–
100 nmol range was developed. Confocal laser scanning
microscopy (CLSM) in combination with gel-capillary
electrophoresis and laser induced fluorescence detection
(GCE-LIF) revealed cytoplasmic and nuclear accumula-tion in all cases. ...
CHAPTER 3 7 COMPUTER-INTEGRATED MANUFACTURING William E. Biles Department of Industrial Engineering University of Louisville Louisville, Kentucky Magd £. Zohdi Department of Industrial and Manufacturing Engineering Louisiana State University Baton Rouge, Louisiana
1 8 1 7 37.4
DEFINITIONS AND CLASSIFICATONS 1 8 1 8 37.2.1 Automation 1188 37.2.2 Production Operations 1189 37.2.3 Production Plants 1190 37.2.4 Models for Production 37.5 Operations 1190 NUMERICAL-CONTROL MANUFACTURING SYSTEMS 1192 37.3. 1 Numerical Control 1 192 37.3.2 The Coordinate System 1192 37.
Moerman et al. EJNMMI Research 2011, 1:12 http://www.ejnmmires.com/content/1/1/12
P-glycoprotein at the blood-brain barrier: kinetic modeling of 11C-desmethylloperamide in mice using a 18F-FDG μPET scan to determine the input function
Lieselotte Moerman1*, Dieter De Naeyer2, Paul Boon3 and Filip De Vos1
Purpose: The objective of this study is the implementation of a kinetic model for 11C-desmethylloperamide (11CdLop) and the determination of a typical parameter for P-glycoprotein (P-gp) functionality in mice.
.Đánh giá máy in Canon Pixma E500
Pixma E500 hoạt động còn chậm nhưng bù lại chất lượng bản in rất tốt, đặc biệt là so với tầm giá và đa tính năng kèm cả scan và photocopy.
Canon Pixma E500.
Sau dòng MG đa tính năng với giá bán hấp dẫn, Canon thậm chí còn muốn tiến sâu hơn và series các mẫu máy in với mức giá rẻ nhiều tính năng bằng model E500. Sản phẩm này có thể in đen trắng, in màu, thậm chí cả scan và photo với mức giá chỉ 2,7 triệu đồng. Sản phẩm thích hợp...
There is value in minimally invasive investigations for ‘difficult’ pains, such as bone scans, MRI, CT and
electrophysiological testing. There is a need for clear information on what pain services can provide and how they
may be accessed. Better links between palliative care and specialist pain services are also important.
Care of a patient suffering from cancer pain requires a holistic approach combining psychological support, social
support, rehabilitation and pain management in order to provide the best possible quality of life or quality of
Staphylococcalnuclease is a single domain protein with 149 amino acids. It
has no disulfide bonds, which makes it a simple model for the study of pro-tein folding. In this study, 20 mutants of this protein were generated each
with a single base substitution of glycine for negatively charged glutamic
acid or aspartic acid. Using differential scanning microcalorimetry in ther-mal denaturation experiments, we identified two mutants, E75G and
E129G, having approximately 43% and 44%, respectively, lowerDHcal
values than the wild-type protein....
Because the photopolymer used in the SL process tends to curl or sag
as it cures, models with overhangs or unsupported horizontal sections
must be reinforced with supporting structures: walls, gussets, or
columns. Without support, parts of the model can sag or break off before
the polymer has fully set. Provision for forming these supports is
included in the digitized fabrication data. Each scan of the laser forms
support layers where necessary while forming the layers of the model.
In an ideal world scientists would not use animals (mainly mice and
rats) for medical research. They would use alternative techniques.
In fact, they are doing so increasingly. Non-animal methods
now account for about 90% of medical research and include
mathematical and computer models, advanced tissue and cell
cultures and scanning technology.
However, the scientiﬁc consensus is that many key questions can
still only be answered by animal studies.