It has been considered that vitamin E is the
major membrane bound antioxidant employed in humans, and thus this lipophilic chain
breaking antioxidant has the ability to inhibit lipid peroxidation. Synergistic actions
between vitamin C and vitamin E therefore appear important in their preventive activity
against lipid peroxidation. Human trials and in-vitro studies have shown that oxidative
stress causes a rapid depletion of vitamin C and vitamin E (reviewed by Bouayed & Bohn,
At the beginning of the 21st century, medicine is increasingly
based on understanding the functions of genes and the molecular
mechanisms of diseases. In pancreatology, the understanding
of functions and dysfunctions of the exocrine and
endocrine pancreas is derived from molecular biological data
on the actions of compounds in subcellular compartments and
intracellular transcription pathways.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines' unexpected therapeutic properties...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Inhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18
Prohibitin (PHB-1) is a highly conserved protein involved in mitochondrial
biogenesis and function. It is secreted in lipid droplets from adipocytes and
is present in the circulation. In adipose tissue it functions as a membrane
receptor and can target binding partners to the mitochondria.
Testican-1, a secreted proteoglycan enriched in brain, has a
single thyropin domain that is highly homologous to
domains previously shown to inhibit cysteine proteases. We
demonstrate that purified recombinant human testican-1 is a
strong competitive inhibitor of the lysosomal cysteine pro-tease, cathepsin L,withaKiof 0.7nM, but it does not inhibit
the structurally related lysosomal cysteine protease cathep-sin B. Testican-1 inhibition of cathepsin L is independent of
its chondroitin sulfate chains and is effective at both pH 5.5
Oligomeric assemblies of amyloid-b(Ab) are suggested to be central in the
pathogenesis of Alzheimer’s disease because levels of soluble Abcorrelate
much better with the extent of cognitive dysfunctions than do senile plaque
counts. Moreover, such Abspecies have been shown to be neurotoxic, to
interfere with learned behavior and to inhibit the maintenance of hippo-campal long-term potentiation.
Ghrelin, the endogenous ligand for the growth hormone secretagogue
receptor type 1a (GHS-R1a), is a 28 amino acid residue with a post-trans-lational octanoyl modification on Ser3. Despite the biomedical interest in
this hormone, the fine details of its regulation and the mechanisms control-ling its secretion are largely unknown.
The molecular chaperone Grp94 (gp96) of the endoplasmic reticulum (ER)
lumen plays an essential role in the structural maturation and⁄or secretion of
proteins destined for transport to the cell surface. Its proposed role in binding
and transferring peptides for immune recognition is, however, controversial.
A large number of bioactive peptides have been isolated
from amphibian skin secretions. These peptides have a
variety of actions including antibiotic and anticancer acti-vities and the inhibition of neuronal nitric oxide synthase.
We have investigated the structure–activity relationship of
citropin 1.1, a broad-spectrum antibiotic and anticancer
agent that also causes inhibition of neuronal nitric oxide
synthase, by making a number of synthetically modified
Two neuropeptides have been isolated and identi®ed from
the secretions of the skin glands of the Stony Creek Frog
Litoria lesueuri. The ®rst of these, the known neuropeptide
caerulein 1.1, is a common constituent of anuran skin
secretions, and has the sequence pEQY(SO3
. This neuropeptide is smooth muscle active, an anal-gaesic more potent thanmorphine and is also thought to be
release of STH (and also other peptide hormones including insulin, glucagon, and gastrin). PRH: prolactin-RH remains to be characterized or established. Both TRH and vasoactive intestinal peptide (VIP) are implicated. PRIH inhibits the release of prolactin and could be identical with dopamine. Hypothalamic releasing hormones are mostly administered (parenterally) for diagnostic reasons to test AH function. Therapeutic control of AH cells. GnRH is used in hypothalamic infertility in women to stimulate FSH and LH secretion and to induce ovulation.
process both reduces collagen synthesis by
inhibiting the smooth muscle cell and causes its
death by apoptosis. Macrophages also produce
a wide range of metalloproteinases capable of
degrading all the components of the connective
tissue matrix, including collagen. These metalloproteinases
are secreted into the tissues in an
inactive form and then activated by plasmin.
Metalloproteinase production by macrophages
is upregulated by inflammatory cytokines such
Gonadotropin-releasing hormone antagonists (GnRH-nt) available for clinical use are GnRH molecules with amino acid modiﬁcations in positions 1, 2, 3, 6, and 10. They are not associated with the histaminic-release effects of previous compounds (1). These compounds immediately block GnRH receptor in a competitive fashion (2). They decrease the luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion within a period of eight hours. Inhibition of LH secretion is more important than FSH.
The ATP-sensitive potassium (KATP) channel couples glucose metabolism
to insulin secretion in pancreatic b-cells. It comprises regulatory sulfonyl-urea receptor 1 and pore-forming Kir6.2 subunits. Binding and⁄or hydro-lysis of Mg-nucleotides at the nucleotide-binding domains of sulfonylurea
receptor 1 stimulates channel opening and leads to membrane hyperpolari-zation and inhibition of insulin secretion.