The international Colloquium “Open Issues in Local Star Formation
and Early Stellar Evolution” was held in Ouro Preto (Brazil) from April
05 to 10, 2003. The Colloquium took place in the “Parque Metal´urgico”,
an old iron industry that has been transformed into a nice modern conference
center. Ouro Preto is a 18th century colonial city that has been
declared a Cultural Heritage of Mankind in 1980. It is situated in the
hills of the State of Minas Gerais at about 100 km from Belo Horizonte....
Data is increasingly generated by instruments that monitor the
environment – telescopes looking at the heavens, DNA sequenc-
ers decoding molecules, bar-code readers watching passing
freight-cars, patient monitors watching the life-signs of a person
in the emergency room, cell-phone and credit-card systems look-
ing for fraud, RFID scanners watching products flow through the
supply chain, and smart-dust sensing its environment.
In each of these cases, one wants to compare...
It is assumed that protein fibrils manifested in amyloidosis result from an
aggregation reaction involving small misfolded protein sequences being
in an ‘oligomeric’ or ‘prefibrillar’ state. This review covers recent optical
spectroscopic studies of amyloid protein misfolding, oligomerization and
amyloid fibril growth.
Neuronal PAS domain protein 2 (NPAS2) is an important transcription
factor associated with circadian rhythms. This protein forms a heterodimer
with BMAL1, which binds to the E-box sequence to mediate circadian
rhythm-regulated transcription. NPAS2 has two PAS domains with heme-binding sites in the N-terminal portion. In this study, we overexpressed
wild-type and His mutants of the PAS-B domain (residues 241–416) of
mouse NPAS2 and then purified and characterized the isolated heme-bound proteins....