Severe cutaneous

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  • Several new aspects have been highlighted: for example, a novel role for lipids as receptors which drive protein sorting, the diversity of the sorting events that occur at the level of the Golgi apparatus, and the cross talk between exocytosis and autophagy. Moreover, an interesting example of how the knowledge of these pathways is exploited to generate novel secretory routes to direct the synthesis of bio-molecules in “cell factories” is discussed.

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  • Delayed hypersensitivity mechanisms directed by drug-specific T cells are probably the most important mechanisms in the etiology of the most common drug eruptions—morbilliform exanthems—and also of rare and severe forms such as hypersensitivity syndrome, acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Drugspecific T cells have been detected in these types of drug eruptions. Contrary to what has been believed for years, the antigen is more often the native drug itself than its metabolites.

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  • Harrison's Internal Medicine Chapter 56. Cutaneous Drug Reactions CUTANEOUS DRUG REACTIONS: INTRODUCTION Cutaneous reactions are among the most frequent adverse reactions to drugs. Every physician will see patients suffering from them. Most are benign, but a few can be life-threatening. Prompt recognition of severe reactions, drug withdrawal, and appropriate therapeutic interventions can minimize toxicity.

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  • Untoward cutaneous responses to drugs can arise as a result of immunologic or nonimmunologic mechanisms. A variety of adverse reactions result from mechanisms that do not involve an immunologic process. Drug reactions are a public health problem because of their frequent occurrence, occasional severity, and impact on the use of medications. The skin is among the organs most often affected by adverse drug reactions. The list of conditions that can be triggered by medications includes nearly all dermatologic diseases.

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  • These reactions are characterized by one or more sharply demarcated, erythematous lesions, sometimes leading to a blister. Hyperpigmentation results after resolution of the acute inflammation. With rechallenge, the lesion recurs in the same (i.e., fixed) location. Lesions often involve the lips, hands, legs, face, genitalia, and oral mucosa and cause a burning sensation. Most patients have multiple lesions. Fixed drug eruptions have been associated with phenolphthalein, sulfonamides, cyclines, dipyrone, NSAIDs, and barbiturates.

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  • Allopurinol Together with sulfonamides and antiepileptics, allopurinol is one of the "usual suspects" that induce frequently mild maculopapular eruptions (in at least 3% of users) and may also cause more severe reactions including hypersensitivity/DRESS and SJS/TEN. Because of increasing utilization it is one of the most frequent causes of life-threatening reactions. Anti-HIV Medications In clinical trials, combinations of highly active antiretroviral treatments were frequently associated with ≥10% "drug eruptions.

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  • We find strong evidence that having access to a car is particularly important for black and Latino workers. We find a difference in employment rates between car-owners and non car-owners that is considerably larger among black workers than among white workers. Moreover, the car- employment effect for Latino workers is significantly greater than the comparable effect for non- Latino white workers yet significantly smaller than the effect for black workers.

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  • On August 21, 2012, the Court of Appeals for the Fifth Circuit overturned the lower court and lifted the preliminary injunction, reasoning that “Texas’s authority to directly regulate the content of its own program necessarily includes the power to limit the identifying marks that program grantees are authorized to use” and therefore, “Texas may deny WHP funds from organizations that promote elective abortions through identifying marks,” such as the Planned Parenthood name and logo.

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  • The success of Selznick, in particular, as an independent producer working closely with the studios, pointed the way towards what was to be the future structure of Hollywood production, which became increasingly organized on a contracted-out basis from the 1950s onwards. The studio production-line system gave way to the package system, in which individual film projects were put together on a one- off basis.

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  • Two elements instil a degree of moderate optimism going forward. First, major policy decisions have significantly reduced tail risks and relieved market stress. The June European Council decisions were swiftly followed up with concrete progress towards establishing a Banking Union. The European Council of 18-19 October agreed on a timetable for the establishment of a Single Supervisory Mechanism and advanced further on the deepening of EMU, encompassing the financial, budgetary, economic, and political dimensions.

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  • Two cell lines were created; Flp293A and 293 FLEX, both derived from 293 cells. The former pseudotyped with amphotropic and the latter with GaLV envelopes. Recently, a PG13-based murine producer cell line was also established using this strategy (Loew et al. 2009). A favorable chromosomal site for stable and high retroviral vector production is first identified and tagged.

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  • The Business Roundtable Institute for Corporate Ethics is an independent entity established in partnership with Business Roundtable—an association of chief executive officers of leading corporations with a combined workforce of more than 10 million employees and $4 trillion in annual revenues—and leading academics from America’s best business schools.

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  • Among seniors, food choice and related activities are affected by health status, biological changes wrought by aging and functional abilities, which are mediated in the larger arena by familial, social and economic factors. Determinants of healthy eating stem from individual and collective factors. Individual components include age, sex, education, physiological and health issues, psychological attributes, lifestyle practices, and knowledge, attitudes, beliefs and behaviours, in addition to other universal dietary determinants such as income, social status and culture.

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  • During the last decade consumer groups, parents and teachers’ bodies, and public health advocacy organisations have called for greater control on the marketing of foods and beverages to children. A number of authoritative reports have highlighted the need to restrict such marketing to ensure that children are not unduly influenced to consume foods high in fats, sugar and salt. A 2009 review of regulations (the PolMark study1) suggested that successful regulation required government leadership with specified timelines and clear, measurable objectives.

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  • A more widely used device is the buying and selling of futures contracts on the commodities exchange. All individuals or firms holding agricultural commodities for which futures markets are available may guard -- "hedge" -- against price changes. Essential marketing services are performed by the people who run the futures exchange and enforce its trading rules, the brokers who act as agents on the floor of the exchange, and the speculators who assume the risks and thus make hedging possible.

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  • To determine why some teachers are more effective than others, Bosshardt and Watts (1990) investigated teacher effects on student learning in high school economics classes using fixed- and random-effects models. The teacher characteristics they examined included college credits in economics, non-credit workshops in economics, years of teaching experience, and the extent of teachers’ past instruction in economics. They found that the most effective teachers were those who had completed more courses in economics.

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  • As a result of adaptation to desert conditions, camels acquire the ability to produce diluted milk. This involves the production of milk with a higher water content when the animal is dehydrated than when it is fully watered. They do this by withdrawing water preferentially from the intestines under the action of prolactin and oxytocin. The ability to dilute milk under similar conditions of water stress has also been demonstrated in women and in cows. Milk dilution is not known in other mammals.

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  • Cutaneous reactions are among the most frequent adverse reactions to drugs. Every physician will see patients suffering from them. Most are benign, but a few can be life-threatening. Prompt recognition of severe reactions, drug withdrawal, and appropriate therapeutic interventions can minimize toxicity. This chapter focuses on adverse cutaneous reactions to drugs other than topical agents; it covers their incidence, patterns, and pathogenesis and provides some practical guidelines on treatment, assessment of causality, and future utilization of drugs.

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  • Information Technology, which is one of global competitive technologies in Korea, was introduced to utilize the production area more efficiently. Chang (2006) has reported a using of a wireless internet environment and PDA system to exchange real time information data between the workers. Shin (2006) has presented a prototype of block tracking system for pre-erection area using of PDA and GPS to chase the location of each block and to exchange the pre-erection work order.

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  • Because CHWs hold the esteem of their peers, they are effective in promoting change and challenging stigma surrounding HIV/AIDS, harmful traditional practices, and prejudices against family planning. They are motivated by a sense of duty to care for others around them and many were caring for others long before they received Pathfinder’s training. The training enables them to offer a wider range of services, gives them confidence that they are giving correct advice, and teaches them how to safely care for people living with HIV/AIDS.

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