Severe skin

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: "Severe skin reaction secondary to concomitant radiotherapy plus cetuximab...

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  • Malassezia are common lipiddependent fungi that grow on the sebaceous areas of human skin. Malassezia can cause and exacebate several skin diseases: Tinea versicolor, pitirosporum folliculitis and seborrheic dermatitis. Malassezia also have been associated with subsets of psoriasis and atopic dermatitis, especially those affecting the scalp.

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  • Factors predisposing to colorectal cancer in UC patients consist of pancolitis, duration of disease, active disease and its severity. Early UC onset is another independent risk factor. Beside these factors, dysplasia represents the precancerous lesion from which colorectal cancer subsequently arise (Morson, 1962; Morson & Pang, 1967). In fact, 70% of patients with colorectal cancer on UC have dysplasia on colorectal mucosa (Taylor et al., 1992; Connell et al., 1994).

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  • Migratory erythema with erosions; favors lower extremities and girdle area In erythema gyratum repens, one sees numerous mobile concentric arcs and wavefronts that resemble the grain in wood. A search for an underlying malignancy is mandatory in a patient with this eruption. Erythema migrans is the cutaneous manifestation of Lyme disease, which is caused by the spirochete Borrelia burgdorferi. In the initial stage (3–30 days after tick bite), a single annular lesion is usually seen, which can expand to ≥10 cm in diameter.

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  • Also systemic. f In adults, associated with renal failure and immunocompromised state. Vesicles and bullae are also seen in contact dermatitis, both allergic and irritant forms (Chap. 53). When there is a linear arrangement of vesicular lesions, an exogenous cause should be suspected. Bullous disease secondary to the ingestion of drugs can take one of several forms, including phototoxic eruptions, isolated bullae, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) (Chap. 56).

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  • Several metabolic disorders are associated with blister formation, including diabetes mellitus, renal failure, and porphyria. Local hypoxia secondary to decreased cutaneous blood flow can also produce blisters, which explains the presence of bullae over pressure points in comatose patients (coma bullae). In diabetes mellitus, tense bullae with clear viscous fluid arise on normal skin. The lesions can be as large as 6 cm in diameter and are located on the distal extremities. There are several types of porphyria, but the most common form with cutaneous findings is PCT.

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  • Common causes of erythematous subcutaneous nodules include inflamed epidermoid inclusion cysts, acne cysts, and furuncles. Panniculitis, an inflammation of the fat, also presents as subcutaneous nodules and is frequently a sign of systemic disease. There are several forms of panniculitis, including erythema nodosum, erythema induratum/nodular vasculitis, lupus profundus, lipodermatosclerosis, α1-antitrypsin deficiency, factitial, and fat necrosis secondary to pancreatic disease. Except for erythema nodosum, these lesions may break down and ulcerate or heal with a scar.

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  • Systemic causes of nonpalpable purpura fall into several categories, and those secondary to clotting disturbances and vascular fragility will be discussed first. The former group includes thrombocytopenia (Chap. 109), abnormal platelet function as is seen in uremia, and clotting factor defects. The initial site of presentation for thrombocytopenia-induced petechiae is the distal lower extremity.

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  • Pemphigus Foliaceus Pemphigus foliaceus (PF) is distinguished from PV by several features. In PF, acantholytic blisters are located high within the epidermis, usually just beneath the stratum corneum. Hence PF is a more superficial blistering disease than PV. The distribution of lesions in the two disorders is much the same, except that in PF mucous membranes are almost always spared. Patients with PF rarely demonstrate intact blisters but rather exhibit shallow erosions associated with erythema, scale, and crust formation.

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  • Bullous Pemphigoid Bullous pemphigoid (BP) is a polymorphic autoimmune subepidermal blistering disease usually seen in the elderly. Initial lesions may consist of urticarial plaques; most patients eventually display tense blisters on either normalappearing or erythematous skin (Fig. 55-2). The lesions are usually distributed over the lower abdomen, groin, and flexor surface of the extremities; oral mucosal lesions are found in some patients. Pruritus may be nonexistent or severe.

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  • Pemphigoid Gestationis Pemphigoid gestationis (PG), also known as herpes gestationis, is a rare, nonviral, subepidermal blistering disease of pregnancy and the puerperium. PG may begin during any trimester of pregnancy or present shortly after delivery. Lesions are usually distributed over the abdomen, trunk, and extremities; mucous membrane lesions are rare. Skin lesions in these patients may be quite polymorphic and consist of erythematous urticarial papules and plaques, vesiculopapules, and/or frank bullae. Lesions are almost always very pruritic.

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  • Linear IgA Disease Linear IgA disease, once considered a variant form of dermatitis herpetiformis, is actually a separate and distinct entity. Clinically, these patients may resemble individuals with DH, BP, or other subepidermal blistering diseases. Lesions typically consist of papulovesicles, bullae, and/or urticarial plaques predominantly on central or flexural sites. Oral mucosal involvement occurs in some patients. Severe pruritus resembles that seen in patients with DH.

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  • Dermatomyositis The cutaneous manifestations of dermatomyositis (Chap. 383) are often distinctive but at times may resemble those of systemic lupus erythematosus (SLE) (Chap. 313), scleroderma (Chap. 316), or other overlapping connective tissue diseases (Chap. 316). The extent and severity of cutaneous disease may or may not correlate with the extent and severity of the myositis.

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  • Many of us are skin conscious. We often want our skin to look young and healthy and we really do something just to protect our skin from whatever possible harms there may be in our environment. Well, our skin is our largest organ performing several functions. It primarily protects us against the invasion of foreign substances and it serves as the transfer point for the release of toxins from our bodies, thus our skin is just worthy of protection and care. Now, if you found yourself coveting the gorgeous skin of fashion models and celebrities in most of today’s...

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  • This Part of BS 5950 gives recommendations for the use of profiled steel sheeting as “stressed skin” shear diaphragms, including the design and construction of such diaphragms, their effects on the design of structural frameworks and the design of frameless steel structures. It also gives worked examples showing the application of the method to several different design cases.

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  • There are several reasons that may explain why the prevalence of heart failure is increasing: ageing of the population, the success in prolonging survival in coronary patients, and the success in postponing coronary events by effective prevention in those patients at high risk or those patients who have already survived a first event (secondary prevention) (Senni et al, 1999). Advances in medical therapy have resulted in improved survival in patients with moderate and severe heart failure, but the prognosis for end-stage heart failure patients still remains poor.

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  • Infectious diseases continue to represent a major diagnostic and therapeutic challenge in the critical care unit. Infectious diseases maintain their preeminence in the critical care unit setting because of their frequency and importance in the critical unit patient population. Since the first edition of Infectious Diseases in Critical Care Medicine, there have been newly described infectious diseases to be considered in differential diagnosis, and new antimicrobial agents have been added to the therapeutic armamentarium.

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  • Welcome to the third edition of Understanding Medical Surgical Nursing! We have fully updated all the material, and have added exciting new information on home health care, end-of-life care, disaster response and bioterrorism, stroke, and more. We continue to work hard to provide a text written at an understandable level, with features that help students understand, apply, and practice the challenging content required to function as practical/vocational nurses. We are thankful to the many students who tell us they find the book very readable, and actually enjoyable.

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  • The modular producer cell lines present several advantages: they are safer since integration of the vector within the packaging cell line was identified, the duration of the entire development process is much reduced as there is no need for screening and, in addition, production conditions are favorable due to the possibility of pre-adaptation of the master cell line to culture conditions and media. Thus, therapeutic virus production from bench to bedside becomes safer, faster, and cheaper (Coroadinha et al. 2010)....

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  • Why a book on cutaneous vascular proliferations? There are several compelling reasons to justify the existence of a book on this topic. One of the most important is that cutaneous vascular proliferations are exceedingly common and affect a large number of individuals of both sexes and within a wide age range. They make up a broad spectrum of lesions with morphological and biological variations, ranging from hamartomas to highly malignant, aggressive neoplasms.

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