Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Research In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer's disease...
Scientific perception of nature relies on a process
of transforming data to information, and then
information into understanding. Data consist of
observations and measurements and information
is data organized according to some ontology,
i.e. some set of assumptions about what entities
exist and how they should be classified. Understanding
is a model in the investigator’s mind that
describes how the entities relate to each other,
a model created in the investigator’s mind as a
result of thinking.
NFκB plays an important role in the immune system in all organisms. In this study, physicochemical properties and modelling of finfish NFκBIα protein was analysed using in silico approach. Finfish species: guppy (Poecilia reticulate), Bicolor damselfish (Stegastes partitus), Channel catfish (Ictalurus punctatus), Coelacanth (Latimeria chalumnae), and Australian ghostshark (Callorhinchus milii) were used in this study.
The discovery of efficacious new human therapeutic agents is one of humanity’s most vital
tasks. It is an enormously demanding activity that requires creativity, a vast range of scientific
knowledge, and great persistence. It is also an exceedingly expensive activity. In an
ideal world, no education would be complete without some exposure to the ways in which
new medicines are discovered and developed. For those young people interested in science
or medicine, such knowledge is arguably mandatory....
During the past two decades, reductionist biological science has generated new
empirical data on the molecular foundations of biological structure and function
at an accelerating rate. The list of organisms whose complete genomes have been
sequenced is growing by the week. Annotations of these sequences are becoming
more comprehensive, and databases of protein structure are growing at impressive,
indeed formerly unimaginable rates.
Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " In silico experimentation with a model of hepatic mitochondrial folate metabolism
MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate gene expression by cleaving mRNAs or inhibiting translation. The baboon is a well-characterized cardiovascular disease model; however, no baboon miRNAs have been identified. Evidence indicates that the baboon and human genomes are highly conserved; based on this conservation, we hypothesized that comparative genomic methods could be used to identify baboon miRNAs.
Mutagenesis is a powerful method directed towards mutating genes or engineering
genome for functional analysis, producing mouse models of human disease, and
understanding molecular mechanism of biodiversity at different levels of biological
organizations. Several insights have been revealed through studies using experimental
models, or in silico, on natural mutations in general and site-specific mutagenesis in
particular. However, unified text on recent trends in mutagenesis is poorly available
within a single cover.
To address questions of protein stability, researchers have
increasingly turned to combinatorial approaches that permit
the rapid analysis of libraries of protein variants. Phage-displayhasprovedtobeapowerful tool foranalyzingprotein
stabilitydue to the large library sizeand the robustnessof the