Highlights in Skincancer is a companion handbook published expressly for all the practitionners who are interested in skin cancers: medical oncologists and dermatologists but also residents, general practitionners, surgeons, plastic surgeons. The book is designed to teach new aspects of skincancers in the context of practical clinical settings. Each topic is an expert view of a specific skincancer field.
Harrison's Internal Medicine Chapter 86. Breast Cancer
Breast Cancer: Introduction
Breast cancer is a malignant proliferation of epithelial cells lining the ducts or lobules of the breast. In the year 2007, about 180,510 cases of invasive breast cancer and 40,910 deaths occurred in the United States. Epithelial malignancies of the breast are the most common cause of cancer in women (excluding skin cancer), accounting for about one-third of all cancer in women.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Individual and setting level predictors of the implementation of a skin cancer prevention program: a multilevel analysis
But risk factors don’t tell us everything. Having a risk factor, or even several risk factors,
does not mean that you will get the disease. And some people who get the disease may have
few or no known risk factors. Even if a person with basal or squamous cell skin cancer has a
risk factor, it is often very hard to know how much that risk factor may have contributed to
The following are known risk factors for basal cell and squamous cell carcinomas. (These
factors don't necessarily apply to other forms of non-melanoma skin cancer, such as...
UNG THƯ DA (Skin cancer)
Hè vàng, Hè vàng. Mỗi năm Hè đến, nhìn nắng chói chang, chúng ta nhớ nhắc nhở nhau về ung thư da. Ung thư da xảy ra cho 1 trong 6 người ở Mỹ. Ung thư da có ba loại: nhiều nhất basal cell cancer, thứ đến squamous cell cancer, rồi đến melanoma. Tuy xảy ra ít hơn, song melanoma lại là loại ung thư da độc nhất, gây tử vong dữ nhất. Trong các loại ung thư ở Mỹ, ung thư da melanoma nhiều đứng hàng thứ 8, và là ung thư đang trên đà...
This is not only the most common type of skin cancer, but the most common type of cancer
in humans. About 8 out of 10 skin cancers are basal cell carcinomas (also called basal cell
cancers). They usually develop on sun-exposed areas, especially the head and neck. Basal
cell carcinoma was once found almost entirely in middle-aged or older people. Now it is also
being seen in younger people, probably because they are spending more time out in the sun.
When seen under a microscope, basal cell carcinomas share features with the cells in the
lowest layer of the...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: The initial experience of electronic brachytherapy for the treatment of non-melanoma skin cancer...
Squamous cell carcinoma in situ, also called Bowen disease, is the earliest form of squamous
cell skin cancer. “In situ” means that the cells of these cancers are still only in the epidermis
and have not invaded the dermis.
Bowen disease appears as reddish patches. Compared with actinic keratoses, Bowen disease
patches tend to be larger (sometimes over 1/2 inch across), redder, scalier, and sometimes
Like invasive squamous cell skin cancers, the major risk factor is too much sun exposure.
Bowen disease can also occur in the skin of the anal and genital areas.
(BQ) Part 1 book "Evidence-Based dermatology" presents the following contents: The concept of evidence-based dermatology, the critical appraisal toolbox, the evidence (common inflammatory skin diseases, skin cancer, moles, and actinic keratoses).
(BQ) Part 1 book "Personalized treatment options in dermatology" presents the following contents: Concept and scientific background of personalized medicine; melanoma - from tumor specific mutations to a new molecular taxonomy and innovative therapeutics; targeted and personalized therapy for nonmelanoma skin cancers; personalized treatment in cutaneous T-cell lymphoma.
Factors predisposing to colorectal cancer in UC patients consist of pancolitis, duration of
disease, active disease and its severity. Early UC onset is another independent risk factor.
Beside these factors, dysplasia represents the precancerous lesion from which colorectal
cancer subsequently arise (Morson, 1962; Morson & Pang, 1967).
In fact, 70% of patients with colorectal cancer on UC have dysplasia on colorectal mucosa
(Taylor et al., 1992; Connell et al., 1994).
Harrison's Internal Medicine Chapter 83. Cancer of the Skin
Melanoma Pigmented lesions are among the most common findings on skin examination. The challenge is to distinguish cutaneous melanomas, which may be lethal, from the remainder, which with rare exceptions are benign. Examples of malignant and benign pigmented lesions are shown in Fig. 83-1.
Atypical and malignant pigmented lesions. The most common melanoma is superficial spreading melanoma (not pictured). A.
The most important prognostic factor is the stage at the time of presentation. Fortunately, most melanomas are diagnosed in clinical stages I and II. The revised American Joint Committee on Cancer (AJCC) staging system for melanoma is based on microscopic primary tumor depth (Breslow's thickness), presence of ulceration, evidence of nodal involvement, and presence of metastatic disease to internal sites (Table 83-3). Certain anatomic sites may affect the prognosis.
A lifetime risk of melanoma development of 6% has been estimated. The risk is greatest before age 5 and next greatest between ages 5 and 10. Early detection of melanoma is difficult in these lesions because of the deep dermal or subcutaneous origin of primary melanoma and because of the large and varied surface of the nevus. Prophylactic excision early in life can be accomplished by staged removal with coverage by split-thickness skin grafts. Surgery cannot remove all at-risk nevus cells as some may penetrate into the muscles or central nervous system below the nevus. At present there are...
The pelvic examination begins with a visual inspection of the external geni-
talia using the assistance of a good light source. Although skin cancer is rare
in this region, it is often diagnosed late. Vulvar cancer can be hyperpig-
mented, erythematous, or hypopigmented, and any such lesions require care-
ful evaluation and often biopsy (see Chapter 17). Lichen sclerosus is a
relatively common condition in which the vulvar skin may appear like parch-
ment. It is more common in postmenopausal women, but occurs in all ages,
and can be associated with cancer. ...
More common than tunnel infections are exit-site infections, often with erythema around the area where the line penetrates the skin. Most authorities (Chap. 129) recommend treatment (usually with vancomycin) for an exit-site infection caused by a coagulase-negative Staphylococcus. Treatment of coagulasepositive staphylococcal infection is associated with a poorer outcome, and it is advisable to remove the catheter if possible. Similarly, many clinicians remove catheters associated with infections due to P.
There are four types of cutaneous melanoma (Table 83-2). In three of these—superficial spreading melanoma, lentigo maligna melanoma, and acral lentiginous melanoma—the lesion has a period of superficial (so-called radial) growth during which it increases in size but does not penetrate deeply. It is during this period that the melanoma is most capable of being cured by surgical excision. The fourth type—nodular melanoma—does not have a recognizable radial growth phase and usually presents as a deeply invasive lesion, capable of early metastasis.
Squamous Cell Carcinoma
The natural history of SCC depends on both tumor and host characteristics. Tumors arising on actinically damaged skin have a lower metastatic potential than those on protected surfaces. The metastatic frequency of cutaneous SCC, reported at 0.3–5.2%, occurs most frequently in regional draining lymph nodes. Tumors occurring on the lower lip and ear have metastatic potentials approaching 13 and 11%, respectively. The metastatic potential of SCC arising in scars, chronic ulcerations, and genital or mucosal surfaces is higher.
This uncommon type of skin cancer develops from neuroendocrine cells (hormone-making
cells that resemble nerve cells in some ways) in the skin. They are most often found on the
head, neck, and arms but can start anywhere.
These cancers are thought to be caused in part by sun exposure and in part by Merkel cell
polyomavirus (MCV). About 8 out of 10 Merkel cell carcinomas are thought to be related to
MCV infection. MCV is a common virus. Many people are infected with MCV, but it usually
causes no symptoms. In a small portion of people with this infection,...