Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Brain metastases from solid tumors: disease outcome according to type of treatment and therapeutic resources of the treating center
The expression of proteoglycans (PGs), essential macromolecules of the
tumor microenvironment, is markedly altered during malignant transforma-tion and tumor progression. Synthesis of stromal PGs is affected by factors
secreted by cancer cells and the unique tumor-modified extracellular matrix
may either facilitate or counteract the growth of solid tumors.
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Integration of chemotherapy into current treatment strategies for brain metastases from solid tumors...
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A tumor cord model for Doxorubicin delivery and dose optimization in solid tumors
The vast majority of published cytogenetic studies of malignancy
have been of leukemias and related hematologic disorders (see Fig. 1),
even though these constitute only about 20% of all cancers. It follows
that most of what is known about the clinical applications of
cytogenetic studies has been derived from hematologic malignancies.
Protein oligomeric complexes have emerged as a major target of current
research because of their key role in aggregation processes in living systems
andin vitro. Hydrophobic and charged surfaces may favour the self-assembly
process by recruiting proteins and modifying their interactions. We found
that equine lysozyme assembles into multimeric complexes with oleic acid
(ELOA) at the solid–liquid interface within an ion-exchange chromatography
column preconditioned with oleic acid.
Formation of new blood vessels is required for the growth and metastasis
of all solid tumors. New blood vessels are established in tumors mainly
through angiogenesis. Brain tumors in particular are highly angiogenic.
Therefore, interventions designed to prevent angiogenesis may be effective
at controlling brain tumors.
Harrison's Internal Medicine Chapter 82. Infections in Patients with Cancer
Infections in Patients with Cancer: Introduction Infections are a common cause of death and an even more common cause of morbidity in patients with a wide variety of neoplasms. Autopsy studies show that most deaths from acute leukemia and half of deaths from lymphoma are caused directly by infection. With more intensive chemotherapy, patients with solid tumors have also become more likely to die of infection.
Another local approach uses adenoviral-mediated expression of the tumor suppressor p53, which is mutated in a wide variety of cancers. This strategy has shown complete and partial responses in squamous cell carcinoma of the head and neck, esophageal cancer, and non-small cell lung cancer after direct intratumoral injection of the vector. Response rates (~15%) are comparable to those of other single agents.
Cancer Cell Biology The treatment of most human cancers with conventional cytoreductive agents has been unsuccessful due to the Gompertzian-like growth kinetics of solid tumors (i.e., tumor growth is exponential in small tumors, with increasing doubling times as tumors expand; since conventional chemotherapeutic agents target proliferating cells, noncycling cells in large tumors are relatively resistant). Genetic instability is inherent in most cancer cells and predisposes to the development of intrinsic and acquired drug resistance. Thus, although tumors arise from a single cell (i.e.
Drawing upon the MDG experience, this session offers an opportunity to reflect on how to put the empowerment of
women and girls and the protection of their rights at the centre of a future global agenda. Two related questions in this
regard are how gender equality could be strengthened by (a) modifying and broadening the indicators for MDG3 and (b)
by focusing on gender equality as a theme across the new development agenda. Many seem to propose a two-pronged
approach of mainstreaming and a standalone target for gender equality. ...
To help ensure accurate measurements, Region 9 recommends that these guidelines
be followed whenever VOCs in soil or other solid matrices are sampled and analyzed.
These guidelines address methods for: (1) handling of samples as intact soil cores; (2)
preserving samples; (3) storing samples in hermetically sealed containers; and (4)
minimizing analyte losses due to direct volatilization (both in the field and the
laboratory) and biodegradation.
Chromosomal Instability in Solid Tumors Solid tumors are generally highly aneuploid, containing an abnormal number of chromosomes; these chromosomes also exhibit structural alterations such as translocations, deletions, and amplifications. Again, colon cancer has proven to be a particularly useful model for the study of chromosomal instability (CIN). As described above, some familial cases are characterized by the presence of MIN.
The taxanes include paclitaxel and docetaxel. These agents differ from the vinca alkaloids in that the taxanes stabilize microtubules against depolymerization. The "stabilized" microtubules function abnormally and are not able to undergo the normal dynamic changes of microtubule structure and function necessary for cell cycle completion. Taxanes are among the most broadly active antineoplastic agents for use in solid tumors, with evidence of activity in ovarian cancer, breast cancer, Kaposi's sarcoma, and lung tumors.
Hematologic Syndromes: Introduction The elevation of granulocyte, platelet, and eosinophil counts in most patients with myeloproliferative disorders is caused by the proliferation of the myeloid elements due to the underlying disease rather than a paraneoplastic syndrome. The paraneoplastic hematologic syndromes in patients with solid tumors are less well characterized than the endocrine syndromes because the ectopic hormone(s) or cytokines responsible have not been identified in most of these tumors (Table 96-2).
Granulocytosis Approximately 30% of patients with solid tumors have granulocytosis (granulocyte count 8000/µL). In about half of patients with granulocytosis and cancer, the granulocytosis has an identifiable nonparaneoplastic etiology (infection, tumor necrosis, glucocorticoid administration, etc.). The other patients have proteins in urine and serum that stimulate the growth of bone marrow cells.
Harrison's Internal Medicine Chapter 105. Malignancies of Lymphoid Cells
Malignancies of Lymphoid Cells: Introduction
Malignancies of lymphoid cells range from the most indolent to the most aggressive human malignancies. These cancers arise from cells of the immune system at different stages of differentiation, resulting in a wide range of morphologic, immunologic, and clinical findings. Insights on the normal immune
system have allowed a better understanding of these sometimes confusing disorders.
Some malignancies of lymphoid cells almost always present as leukemia (i.e.