Solubility principle

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  • Harrison's Internal Medicine Chapter 116. Immunization Principles and Vaccine Use Principles of Immunization The immune system, composed of a variety of cell types and soluble factors, is geared toward the recognition of and response to "foreign" substances termed antigens. Vaccines convey antigens from living or killed microorganisms (or protein or carbohydrate molecules derived from these antigens) to elicit immune responses that are generally protective but can occasionally backfire and cause harm to the recipient.

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  • Pharmacokinetic Interactions Causing Decreased Drug Effects Gastrointestinal absorption can be reduced if a drug interaction results in drug binding in the gut, as with aluminum-containing antacids, kaolin-pectin suspensions, or bile acid sequestrants. Drugs such as histamine H 2 receptor antagonists or proton pump inhibitors that alter gastric pH may decrease the solubility and hence absorption of weak bases such as ketoconazole.

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  • Chapter 10 introduction to metabolism. After studying this chapter you will be able to: Define catabolism and anabolism and know general properties regarding each, know the difference between a heterotroph and a autotroph, know the general spatial organization of pathways (multienzyme complexes, individual soluble proteins, membrane associated),...

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  • The book is intended to provide a sound basis for enzyme reactor design based on kinetic principles, and give an updated vision of the potentials and limitations of enzyme biocatalysis, especially with respect to recent applications in processes of organic synthesis. The book is structured in the form of a textbook that goes from basic principles of enzyme structure and function to reactor design for homogeneous systems with soluble enzymes, and heterogeneous systems with insolubilized enzymes.

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  • Synthesis has a central role in the development of Science especially in Chemistry. The strategies adopted in synthesis of molecules and materials have undergone considerable changes in recent times and it was felt that it may be necessary to assess and assimilate information on this topic in a single place. Though, no originality is claimed to the contents on this topic, the very fact that the available information on this topic is available in one place itself is considered to be a major step forward.

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  • The Sceptical Chymist or Chymico-Physical Doubts & Paradoxes, Touching the Spagyrist's Principles Commonly call'd Hypostatical; As they are wont to be Propos'd and Defended by the Generality of Alchymists. Whereunto is præmis'd Part of another Discourse relating to the same Subject. Author: Robert Boyle Release Date: October 8, 2007

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  • The absorption, distribution, metabolism, and excretion of a drug all involve its passage across cell membranes. Mechanisms by which drugs cross membranes and the physicochemical properties of molecules and membranes that influence this transfer are, therefore, important. The determining characteristics of a drug are its molecular size and shape, degree of ionization, relative lipid solubility of its ionized and nonionized forms, and its binding to tissue proteins.

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  • The immune system, composed of a variety of cell types and soluble factors, is geared toward the recognition of and response to "foreign" substances termed antigens. Vaccines convey antigens from living or killed microorganisms (or protein or carbohydrate molecules derived from these antigens) to elicit immune responses that are generally protective but can occasionally backfire and cause harm to the recipient.

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  • To elucidate the architectural principle of protein structure, we focused on sequestration from solvent, which is a common characteristic of folding and self-associative precipitation. Because protein solubility can be regarded as a basis for the potential ability to sequester from solvent, we assume that poorly soluble proteins tend not only to precipitate, but also to form solution structures.

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