Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift
In the early 1980’s, the Japanese were the
first to recognize dairy components as
having significant contributions to
“physiologically functional foods.” Since
then there has been an increasing number of
investigations that have supported this view.Current evidence for the health benefits of
most dairy foods and dairy components is
based primarily on in vitro and in vivo
animal studies. Human clinical studies are still needed in
Using the broadest possible definition, a lipid (Greek
) may be defined as a compound
of low or intermediate molecular weight (5000), a substantial proportion of which is made up of
hydrocarbons. Included are diverse compounds such as fatty acids; soaps; detergents; steroids;
mono-, di-, and triacylglycerols; and more complex compounds such as phospholipids, sphingolipids,
glycolipids, and lipopolysaccharides.
Sphingolipid activator proteins (SAPs), GM2 activator protein (GM2AP)
and saposins (Saps) A–D are small, enzymatically inactive glycoproteins of
the lysosome. Despite of their sequence homology, these lipid-binding and
-transfer proteins show different specificities and varying modes of action.
Water-soluble SAPs facilitate the degradation of membrane-bound glyco-sphingolipids with short oligosaccharide chains by exohydrolases at the
Protein sorting and assembly in membrane biogenesis and function involves
the creation of ordered domains of lipids known as membrane rafts. The
rafts are comprised of all the major classes of lipids, including glycero-phospholipids, sphingolipids and sterol. Cholesterol is known to interact
with sphingomyelin to form a liquid-ordered bilayer phase.
P-glycoprotein (Pgp), a member of the ATP-binding cassette (ABC) super-family responsible for the ATP-driven extrusion of diverse hydrophobic
molecules from cells, is a cause of multidrug resistance in human tumours.
Pgp can also operate as a phospholipid and glycosphingolipid flippase, and
has been functionally linked to cholesterol, suggesting that it might be
associated with sphingolipid–cholesterol microdomains in cell membranes.