Previous trials have demonstrated that lowering low-density lipoprotein (LDL) cholesterol
levels below currently recommended levels is beneficial in patients with acute coronary
syndromes. We prospectively assessed the efficacy and safety of lowering LDL
cholesterol levels below 100 mg per deciliter (2.6 mmol per liter) in patients with stable
coronary heart disease (CHD).
In patients with stable coronary artery disease, it remains unclear whether an initial
management strategy of percutaneous coronary intervention (PCI) with intensive
pharmacologic therapy and lifestyle intervention (optimal medical therapy) is superior
to optimal medical therapy alone in reducing the risk of cardiovascular events.
We conducted a randomized trial involving 2287 patients who had objective evidence
of myocardial ischemia and significant coronary artery disease at 50 U.S. and Canadian
Angiotensin-converting–enzyme (ACE) inhibitors are effective in reducing the risk of
heart failure, myocardial infarction, and death from cardiovascular causes in patients
with left ventricular systolic dysfunction or heart failure. ACE inhibitors have also been
shown to reduce atherosclerotic complications in patients who have vascular disease
without heart failure.
The level of the inactive N-terminal fragment of pro–brain (B-type) natriuretic peptide
(BNP) is a strong predictor of mortality among patients with acute coronary syndromes
and may be a strong prognostic marker in patients with chronic coronary heart disease
as well. We assessed the relationship between N-terminal pro-BNP (NT-pro-BNP) levels
and long-term mortality from all causes in a large cohort of patients with stable coronary
1/ BỆNH TIM DO THIẾU MÁU CỤC BỘ CẤP TÍNH ĐƯỢC XẾP LOẠI NHƯ THẾ NÀO ?
Bệnh tim do thiếu máu cục bộ ổn định mãn tính. (Chronic stable ischemic heart disease)
Các hợp chứng động mạch vành cấp tính. (Acute coronary syndromes)
Cơn đau thắt ngực không ổn định (unstable angina) Nhồi máu cơ tim cấp tính không nâng cao đoạn ST.(Acute non-ST segment elevation myocardial infarction)
It is only 26 years since the first percutaneous transluminal coronary angioplasty (PTCA) was carried out by the pioneering Swiss
radiologist, Andreas Greuntzig, heralding the dawn of interventional cardiology. In this short time, interventional cardiology has
overcome many limitations and undergone major evolutionary changes—most notably the development of the coronary stent.
Worldwide, many thousands of patients now safely undergo percutaneous coronary intervention every day, and the numbers
continue to grow.
It is spread mainly by bites of infected animals. The virus present
in their saliva is inoculated in the bite trauma. Foxes are the main reservoir
of the disease. Camels can be infected by dog or fox bites, but the chances
of spread from camel to man appear to be small. Nevertheless, camel bites
in endemic (prevalent in a population or geographical areas at all times)
areas should be regarded potentially dangerous, especially if the animal is
showing signs of unusual behaviour at the time of bite or does so within
next 7 to 10 days (signs such as...
Babies exposed to carbon monoxide during the maturation of their organs may suffer
permanent changes to those organs. Studies using newborn rats showed that carbon
monoxide exposure could cause changes in the heart muscle tissue. This is turn could
increase the severity of effects of artery constrictions when they became adults. Other
animal studies have shown that long-term carbon monoxide exposure can contribute to
a disease called ventricular hypertrophy, in which the cells of the heart's ventricle
chambers are enlarged and possibly weakened.
A 73-year-old man with stable coronary artery disease, hypertension, and chronic renal
insufficiency presents with recurrent atrial fibrillation at 80 to 90 beats per minute.
His symptoms include shortness of breath and fatigue. He has had atrial fibrillation
twice in the past year; with each episode, electrical cardioversion resulted in
marked improvement in his symptoms. His echocardiogram shows symmetric left
ventricular hypertrophy with evidence of diastolic dysfunction. His medications include
warfarin and metoprolol (25 mg twice daily).
(BQ) Separate chapters cover ACC/AHA guidelines for percutaneous coronary intervention, chronic stable angina, acute coronary syndromes, and ST-elevation myocardial infarction. A chapter on test-taking is also included.
Hence, the challenge is to include the development of stratification biomarkers into the concept
of disease prevention and drug development. In addition, we should distinguish between
biomarkers and assays. Biomarkers need to be qualified and properly detected before they can be
used in the clinics. Therefore, the applicability of a qualified biomarker relies also on the
development of a robust assay.
Designations used by companies to distinguish their products are often claimed as
trademarks. All brand names and product names used in this book are trade names,
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publisher is not associated with any product or vendor mentioned in this book. This
publication is designed to provide accurate and authoritative information in regard to the
subject matter covered. It is sold on the understanding that the publisher is not engaged
in rendering professional services.
For much of the early history of medicine, the heart was
considered to be the most sacred and mystical of all
human organs. As a General Pediatrician, I tend to expect
that the children I care for will have strong, properly
functioning hearts. However, in situations where the
heart is congenitally malformed or affected by inflammation
or myopathy, it is reassuring and important to have a
pediatric cardiologist and cardiac surgeon at my side to
help me with decisions about further diagnostic testing
and imaging, instituting medical therapy, and assessing
the need for surgical intervention....
Pilot studies suggest that intracoronary transplantation of progenitor cells derived
from bone marrow (BMC) or circulating blood (CPC) may improve left ventricular
function after acute myocardial infarction. The effects of cell transplantation in
patients with healed myocardial infarction are unknown.