Statements and documents scientific reports

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  • Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis Xinhua Yu1, Kristin Bauer1, Dirk Koczan2, Hans-Jürgen Thiesen2 and Saleh M Ibrahim1 1Immunogenetics 2Institute Group, University of Rostock, Schillingallee, 18055 Rostock, Germany for Immunology, University of Rostock, Schillingallee, 18055 Rostock, Germany Corresponding author: Saleh M Ibrahim, saleh.ibrahim@med.uni-rostock.

    pdf9p thulanh13 15-10-2011 45 8   Download

  • Influenza viruses are a major cause of morbidity and mortality around the world. More recently, a swineorigin influenza A (H1N1) virus that is spreading via human-to-human transmission has become a serious public concern. Although vaccination is the primary strategy for preventing infections, influenza antiviral drugs play an important role in a comprehensive approach to controlling illness and transmission. In addition, a search for

    pdf9p toshiba23 18-11-2011 27 8   Download

  • Abstract Although gait change is considered a useful indicator of severity in animal models of Parkinson's disease, systematic and extensive gait analysis in animal models of neurological deficits is not well established. The CatWalk-assisted automated gait analysis system provides a comprehensive way to assess a number of dynamic and static gait parameters simultaneously. In this study, we used the Catwalk system to investigate changes in gait parameters in adult rats with unilateral 6-OHDA-induced lesions and the...

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  • The importance of the Notch signaling in the development of glomerular diseases has been recently described. Therefore we analyzed in podocytes the expression and activity of ADAM10, one important component of the Notch signaling complex. Methods: By Western blot, immunofluorescence and immunohistochemistry analysis we characterized the expression of ADAM10 in human podocytes,

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  • Abstract Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties. This study aims at evaluating the effect of curcumin in modulating the altered dopaminergic receptors, CREB and phospholipase C in the cerebral cortex and cerebellum of STZ induced diabetic rats. Radioreceptor binding assays and gene expression was done in the cerebral cortex and cerebellum of male Wistar rats using specific ligands and probes.

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  • Major burn is associated with decreased gut barrier function and increased bacterial translocation (BT). This study is to investigate whether commensal microflora induce host defense and decrease BT in burn mice. Methods: First, we treated Wild type (WT) mice with antibiotics in drinking water for 4 weeks to deplete gut commensal microflora. At week 3, drinking water was supplemented with lipopolysaccharide (LPS); a ligand for TLR4, to trigger TLRs in gut.

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  • Sindbis virus (SV) is the prototype of alphaviruses which are a group of widely distributed human and animal pathogens. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein that shuttles between the nucleus and the cytoplasm. Our recent studies found that hnRNP A1 relocates from nucleus to cytoplasm in Sindbis virus (SV)-infected cells. hnRNP A1 binds to the 5′ UTR of SV RNA and facilitates the viral RNA replication and translation.

    pdf7p toshiba23 18-11-2011 24 4   Download

  • Collection of research reports best universities honored author. Two. Le Van Dung, a number average convergence theorem for two index array of random elements in Banach spaces with integrable conditions are ... Science (in Latin Scientia, meaning "knowledge "or" understanding ") is the efforts to implement the invention, and increased knowledge of the human understanding of how the operation of the physical world around them.

    pdf10p phalinh14 07-08-2011 33 3   Download

  • Collection of reports on medical research published in medical journals' Respiratory Research give you knowledge of medical subjects: "Traffic-related Air Pollution and Respiratory symptoms Among asthmatic children, resident in Mexico City : the EVA cohort study ...

    pdf11p toshiba12 20-10-2011 35 3   Download

  • Toll-like receptor 4 (TLR4) plays an important role in innate immunity. The role of TLR4 in stretched cardiomyocytes is not known. We sought to investigate whether mechanical stretch could regulate TLR4 expression, as well as the possible molecular mechanisms and signal pathways mediating the expression of TLR4 by cyclic mechanical stretch in cardiomyocytes. Methods: Neonatal Wistar rat cardiomyocytes grown on a flexible membrane base were stretched by vacuum to 20% of maximum elongation at 60 cycles/min.

    pdf13p toshiba23 18-11-2011 26 3   Download

  • Akt regulates various cellular processes, including cell growth, survival, and metabolism. Recently, Akt's role in neurite outgrowth has also emerged. We thus aimed to identify neuronal function-related genes that are regulated by Akt. Methods: We performed suppression subtractive hybridization on two previously established PC12 sublines, one of which overexpresses the wild-type (WT) form and the other, the dominant-negative (DN) form of Akt. These sublines respond differently to NGF's neuronal differentiation effect. Results: A...

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  • The human lmo2 gene plays important roles in hematopoiesis and is associated with acute T lymphocyte leukemia. The gene encodes two protein isoforms, a longer form LMO2-L and a shorter form LMO2-S. Both isoforms function as bridge molecules to assemble their partners together to regulate their target genes. A typical LMO2 binding site consists of two elements, a GATA site and an E-box, with an interval of 9~12 bp. Methods: In this study, the combination of MBP pulldown assay and mammalian two hybrid assay were...

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  • The highly pathogenic H5N1 is a major avian pathogen that crosses species barriers and seriously affects humans as well as some mammals. It mutates in an intensified manner and is considered a potential candidate for the possible next pandemic with all the catastrophic consequences. Methods: Nasal swabs were collected from donkeys suffered from respiratory distress. The virus was isolated from the pooled nasal swabs in specific pathogen free embryonated chicken eggs (SPF-ECE).

    pdf6p toshiba23 18-11-2011 23 3   Download

  • MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate gene expression by cleaving mRNAs or inhibiting translation. The baboon is a well-characterized cardiovascular disease model; however, no baboon miRNAs have been identified. Evidence indicates that the baboon and human genomes are highly conserved; based on this conservation, we hypothesized that comparative genomic methods could be used to identify baboon miRNAs.

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  • Abstract To overcome loss of stem-like properties and spontaneous differentiation those hinder the expansion and application of human mesenchymal stem cells (hMSCs), we have clonally isolated permanent and stable human MSC lines by ectopic overexpression of primary cell cultures of hMSCs with HPV 16 E6E7 and human telomerase reverse transcriptase (hTERT) genes. These cells were found to have a differentiation potential far beyond the ordinary hMSCs. They expressed trophoectoderm and germline specific markers upon differentiation with BMP4 and retinoic acid, respectively.

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  • Anne-Marie Boström*1, Kerstin Nilsson Kajermo2, Gun Nordström3 and Lars Wallin2 Address: 1Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Stockholm, Sweden, 2Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet and Clinical Research Utilization (CRU), Karolinska University Hospital, Stockholm, Sweden and 3Department of Nursing, Karlstad University, Karlstad and Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Stockholm, Sweden Email: Anne-Marie...

    pdf10p toshiba23 11-12-2011 28 3   Download

  • Tailoring an intervention to the context and system redesign related to the intervention: A case study of implementing shared medical appointments for diabetes Susan R Kirsh*1,2, Renée H Lawrence1 and David C Aron1,2 Address: 1Center for Quality Improvement Research, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA and 2School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA Email: Susan R Kirsh* - susan.kirsh@va.gov; Renée H Lawrence - renee.lawrence2@va.gov; David C Aron - david.aron@va.gov * Corresponding author...

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  • Gaston Godin*†1, Ariane Bélanger-Gravel†2, Martin Eccles3 and Jeremy Grimshaw4,5 Address: 1Canada Research Chair on Behaviour and Health, Laval University, Québec, Canada, 2Research Group on Behaviour and Health, Faculty of Nursing, Laval University, Québec, Canada, 3Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK, 4Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario, Canada and 5Department of Medicine, University of Ottawa, Ontario, Canada Email: Gaston Godin* - Gaston.Godin@fsi.ulaval.ca; Ariane Bélanger-Gravel - Ariane.

    pdf12p toshiba23 11-12-2011 23 3   Download

  • Adam wasn’t hungry and was apprehensive about the potential consequences of eating the forbidden fruit. He was, however, convinced the plant material could provide benefits beyond its nutritional value. On the one hand, God told him that its consumption would be fatal, while the serpent contended the plant would impart new knowledge. Both were right. After eating the fruit Adam lost his home and immortality, and was made aware of the concepts of good and evil. He would need this new knowledge to survive in the world outside of Eden....

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  • Opinion Predicting and validating microRNA targets Eric C Lai Address: 545 Life Sciences Addition, Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720-3200, USA. E-mail: lai@fruitfly.org comment Published: 31 August 2004 Genome Biology 2004, 5:115 The electronic version of this article is the complete one and can be found online at http://genomebiology.

    pdf6p thulanh19 09-11-2011 18 2   Download

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