Sustained growth signals

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  • Cancer can be defined as a disease in which a group of abnormal cells grow uncontrollably by disregarding the normal rules of cell division. Normal cells are constantly subject to signals that dictate whether the cell should divide, differentiate into another cell or die. Cancer cells develop a degree of autonomy from these signals, resulting in uncontrolled growth and proliferation. If this proliferation is allowed to continue and spread, it can be fatal. In fact, almost 90% of cancer-related deaths are due to tumour spreading – a process called metastasis....

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  • Several hematopoietic growth factors (HGFs) have achieved widespread clinical application. In the United States alone, more than US $5 billion per year of the health care budget is spent on these factors. The first patients were treated with recombinant human erythropoietin (rHuEPO, epoetin alfa, Epogen®) in 1985 and the first patients received recombinant methionyl human granulocyte colony-stimulating factor (r-metHuG-CSF, filgrastim, Neupogen®) or recombinant human granulocyte-macrophage colonystimulating factor (rHuGM-CSF, sargramostim, Leukine® or Prokine®) in 1986.

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  • Fiscal policy, based on cash-budgeting, aims over the medium term at preserving fiscal sustainability, while allowing for some modest increase in infrastructure and social spending. Given the fiscal framework, Government finances have improved. There are, however, unresolved issues concerning ghost workers and the accounting for diamond revenues. Total revenue increased from US$933.6 million in 2009 to US$2.34 billion in 2010, underpinned by increases in income and corporate taxes.

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  • In the last decade, scientists began to use signaling molecules such as growth factors in their quest to restore destroyed tooth support (Anusaksathien & Giannobile, 2002) and this reason request a very good knowledge of the biological actions of growth factors, both summative and redundant, in the specific “milieu” of periodontal diseases.

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  • If governments wish to encourage investors to finance climate change and green growth projects in future, clear and consistent policies over a long period of time are needed – most notably a clear signal in terms of carbon pricing (e.g. via emissions targets). For example, as Hamilton (2009) points out, renewable energy policy and regulatory framework is the critical element influencing where capital is deployed. Such policy needs to be „loud‟ (i.e.

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