Xem 1-20 trên 153 kết quả Targeted drugs
  • Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : The application of carbon nanotubes in target drug delivery systems for cancer therapies

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer

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  • Introduction: Small amount of drugs and poisons incorporated into human bodies are hidden among large amounts of biological components, such as proteins, lipids, nucleic acids and membranes. It is not easy to detect only a target compound from such complicated matrices. Before instrumental analysis, extraction procedure is usually essential and very important.

    pdf7p bigbaby87 01-09-2010 83 28   Download

  • Over 98 per cent of sprayed insecticides and 95 per cent of herbicides reach a destination other than their target species, including non-target species, air, water and soil. Pesticide drift occurs when pesticides suspended in the air as particles are carried by wind to other areas, potentially contaminating them. Pesticides are one of the causes of water pollution and some pesticides are persistent organic pollutants and contribute to soil contamination. Detection of pesticide molecules in the food items from plant and animal origin become imperative for safe consumption of food.

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  • Adverse Drug Effects premature breakdown of red blood cells (hemolysis) in subjects with a glucose6-phosphate dehydrogenase deficiency. The discipline of pharmacogenetics deals with the importance of the genotype for reactions to drugs. The above forms of hypersensitivity must be distinguished from allergies involving the immune system (p. 72). Lack of selectivity (C). Despite appropriate dosing and normal sensitivity, undesired effects can occur because the drug does not specifically act on the targeted (diseased) tissue or organ.

    pdf8p bigbaby87 04-09-2010 61 14   Download

  • Today, cancer research is focused on determining how genome and proteome level information may be useful as tools in prevention, diagnosis, and prognosis. The development of “omics” technologies, such as proteomics and transcriptomics has opened new research areas for scientists working on cancer research.

    pdf238p lyly_5 22-03-2013 26 5   Download

  • Discovery of a new chemical entity that exerts pharmacological effects for curing or treating diseases or relieving symptoms is only the first step in the drug developmental process. In the developmental cycle of a new drug, the delivery of a desired amount of a therapeutic agent to the target at a specific time or duration is as important as its discovery. In order to realize the optimal therapeutic outcomes, a delivery system should be designed to achieve the optimal drug concentration at a predetermined rate and at the desired location....

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  • The Hsp90 molecular chaperone catalyses the final activa-tion step of many of themost important regulatory proteins of eukaryotic cells. The antibiotics geldanamycin and rad-icicol act as highly selective inhibitors of in vivo Hsp90 function through their ability to bindwithin the ADP/ATP binding pocket of the chaperone. Drugs based on these compounds are now being developed as anticancer agents, their administration having the potential to inactivate sim-ultaneously several of the targets critical for counteracting multistep carcinogenesis. ...

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  • Products of nanotechnology are expected to revolutionize modern medicine, as evidenced by recent scientific advances and global initiatives to support nanotechnology and nanomedicine research. The field of drug delivery is a direct beneficiary of these advancements. Due to their versatility in targeting tissues, accessing deep molecular targets, and controlling drug release, nanoparticles are helping address challenges to face the delivery of modern, as well as conventional drugs.

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  • Great efficiencies have been achieved in the drug discovery process as a result of technological advances in target identification, high-throughput screening, high-throughput organic synthesis, just-in-time in vitro ADME (absorption, distribution, metabolism, and excretion), and early pharmacokinetic screening of drug leads. These advances, spanning target selection all the way through to clinical candidate selection, have placed greater and greater demands on the analytical community to develop robust high-throughput methods.

    pdf41p bigbaby87 03-09-2010 59 17   Download

  • The modern drug discovery process, in general, involves the identification of a biochemical target (usually protein target), screening of synthetic compounds or compound libraries from combinatorial chemistry/natural sources for a lead compound, and optimization of the lead compound (activity, selectivity, pharmacokinetics, etc.) for recommending a potential clinical candidate.

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  • Though alternative methods of controlling insects, rodents, insect pests, pathogens, microbes and weeds have been developed, pesticides could not be replaced. The prosperous role of pesticides in the management of insect pests and diseases is indisputable. However, its nature of non selective toxicity towards other organisms and deposition in the environment warrants the legislation of usage. Pesticide use raises a number of environmental concerns.

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  • This chapter provides a brief overview of the immune response as background for understanding the mechanism of action of immunomodulatory agents. The general principles of pharmacological immunosuppression are discussed in the context of potential targets, major indications, and unwanted side effects.

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  • In this review, will be summarize the principle of these new methodologies and the impact of omics-techniques, mainly genomic-transcriptomics (analysis of single nucleotide polymorphisms or gene-expression) and proteomic (identification and quantification of proteins), in the knowledge of different aspects of allergy diseases (diagnosis, screening, monitoring of treatment, protective or risk biomarkers and drug development) and the advance to define the personalized and molecular medicine in this complex kind of diseases....

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  • The traditional direct marketing paradigm implicitly assumes that there is no possibility of a customer purchasing the product unless he receives the direct promotion. In real business environments, however, there are “voluntary buyers” who will make the purchase even without marketing contact. While no direct promotion is needed for voluntary buyers, the traditional response-driven paradigm tends to target such customers. In this thesis, the traditional paradigm is examined in detail. We argue that it cannot maximize the net profit.

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  • In the time it takes you to make just one in-person sales call, you could stay at your office, pick up the telephone, and potentially reach dozens, if not hundreds, of potential prospects, using basic outbound telemarketing efforts.

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  • Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Drug-therapy networks and the prediction of novel drug targets...

    pdf5p toshiba3 07-09-2011 30 6   Download

  • This book presents basic and advanced principles underlying the multivalent interactions that are prevalent in biological systems. To illustrate important or complex concepts, the book provides up-to-date examples of synthetic multivalent molecules, their design, and their biological benefits. Functional roles displayed by such molecules of both natural and synthetic origin are well documented in biology, where they exert unique and crucial activities at a level not readily achievable by monovalent molecules.

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  • In the second study an attempt was made to determine whether there might be a relationship between reproductive messages and the popularity/sales of recorded contemporary songs. This was accomplished by measuring the number of reproductive messages in 30 randomly selected songs from each of the three charts that made it into the Top Ten in 2009 and also appeared in albums. As a control condition, we measured the number of reproductive messages in randomly selected songs from the same album by the same vocalists that did not make it into the Top 10. As a result, each...

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  • Leadership is required from City staf and elected oicials, from organizations operating in diverse sectors across the city, and from Vancouver residents—many of whom have already contributed to the development of this plan. he City will need to lead the way in its own operations as well, demonstrating what a Greenest City looks like in City-run buildings, facilities, and operations. Leadership from other levels of government and other public sector agencies will also be critical to our success. Action A plan like this is only useful when it is acted upon.

    pdf82p doidieumuonnoi 11-06-2013 31 6   Download

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