Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer
Small amount of drugs and poisons incorporated into human bodies are hidden among large amounts of biological components, such as proteins, lipids, nucleic acids and membranes. It is not easy to detect only a target compound from such complicated matrices. Before instrumental analysis, extraction procedure is usually essential and very important.
Over 98 per cent of sprayed
insecticides and 95 per cent of herbicides reach a destination other than their target
species, including non-target species, air, water and soil. Pesticide drift occurs when
pesticides suspended in the air as particles are carried by wind to other areas,
potentially contaminating them. Pesticides are one of the causes of water pollution and
some pesticides are persistent organic pollutants and contribute to soil contamination.
Detection of pesticide molecules in the food items from plant and animal origin
become imperative for safe consumption of food.
Adverse Drug Effects
premature breakdown of red blood cells (hemolysis) in subjects with a glucose6-phosphate dehydrogenase deficiency. The discipline of pharmacogenetics deals with the importance of the genotype for reactions to drugs. The above forms of hypersensitivity must be distinguished from allergies involving the immune system (p. 72). Lack of selectivity (C). Despite appropriate dosing and normal sensitivity, undesired effects can occur because the drug does not specifically act on the targeted (diseased) tissue or organ.
Today, cancer research is focused on determining how genome and proteome level
information may be useful as tools in prevention, diagnosis, and prognosis. The
development of “omics” technologies, such as proteomics and transcriptomics has
opened new research areas for scientists working on cancer research.
Discovery of a new chemical entity that exerts pharmacological effects for
curing or treating diseases or relieving symptoms is only the first step in
the drug developmental process. In the developmental cycle of a new
drug, the delivery of a desired amount of a therapeutic agent to the target
at a specific time or duration is as important as its discovery. In order
to realize the optimal therapeutic outcomes, a delivery system should
be designed to achieve the optimal drug concentration at a predetermined
rate and at the desired location....
The Hsp90 molecular chaperone catalyses the final activa-tion step of many of themost important regulatory proteins
of eukaryotic cells. The antibiotics geldanamycin and rad-icicol act as highly selective inhibitors of in vivo Hsp90
function through their ability to bindwithin the ADP/ATP
binding pocket of the chaperone. Drugs based on these
compounds are now being developed as anticancer agents,
their administration having the potential to inactivate sim-ultaneously several of the targets critical for counteracting
multistep carcinogenesis. ...
Products of nanotechnology are expected to revolutionize
modern medicine, as evidenced by recent scientific advances
and global initiatives to support nanotechnology and nanomedicine
research. The field of drug delivery is a direct beneficiary
of these advancements. Due to their versatility in
targeting tissues, accessing deep molecular targets, and controlling
drug release, nanoparticles are helping address challenges
to face the delivery of modern, as well as conventional
Great efﬁciencies have been achieved in the drug discovery process as a result of technological advances in target identiﬁcation, high-throughput screening, high-throughput organic synthesis, just-in-time in vitro ADME (absorption, distribution, metabolism, and excretion), and early pharmacokinetic screening of drug leads. These advances, spanning target selection all the way through to clinical candidate selection, have placed greater and greater demands on the analytical community to develop robust high-throughput methods.
The modern drug discovery process, in general, involves the identiﬁcation of a biochemical target (usually protein target), screening of synthetic compounds or compound libraries from combinatorial chemistry/natural sources for a lead compound, and optimization of the lead compound (activity, selectivity, pharmacokinetics, etc.) for recommending a potential clinical candidate.
Though alternative methods of controlling insects, rodents,
insect pests, pathogens, microbes and weeds have been developed, pesticides could
not be replaced. The prosperous role of pesticides in the management of insect pests
and diseases is indisputable. However, its nature of non selective toxicity towards
other organisms and deposition in the environment warrants the legislation of usage.
Pesticide use raises a number of environmental concerns.
This chapter provides a brief overview of the immune response as background for understanding the
mechanism of action of immunomodulatory agents. The general principles of pharmacological
immunosuppression are discussed in the context of potential targets, major indications, and
unwanted side effects.
In this review, will be summarize the principle of these new methodologies and the impact
of omics-techniques, mainly genomic-transcriptomics (analysis of single nucleotide
polymorphisms or gene-expression) and proteomic (identification and quantification of
proteins), in the knowledge of different aspects of allergy diseases (diagnosis, screening,
monitoring of treatment, protective or risk biomarkers and drug development) and the
advance to define the personalized and molecular medicine in this complex kind of diseases....
The traditional direct marketing paradigm implicitly assumes that there is no possibility
of a customer purchasing the product unless he receives the direct promotion. In real
business environments, however, there are “voluntary buyers” who will make the
purchase even without marketing contact. While no direct promotion is needed for
voluntary buyers, the traditional response-driven paradigm tends to target such customers.
In this thesis, the traditional paradigm is examined in detail. We argue that it cannot
maximize the net profit.
In the time it takes you to make just one in-person sales
call, you could stay at your office, pick up the telephone, and
potentially reach dozens, if not hundreds, of potential prospects,
using basic outbound telemarketing efforts.
This book presents basic and advanced principles underlying the multivalent
interactions that are prevalent in biological systems. To illustrate important or
complex concepts, the book provides up-to-date examples of synthetic multivalent
molecules, their design, and their biological benefits. Functional roles
displayed by such molecules of both natural and synthetic origin are well
documented in biology, where they exert unique and crucial activities at a
level not readily achievable by monovalent molecules.
In the second study an attempt was made to determine whether there might be a
relationship between reproductive messages and the popularity/sales of recorded
contemporary songs. This was accomplished by measuring the number of reproductive
messages in 30 randomly selected songs from each of the three charts that made it into the
Top Ten in 2009 and also appeared in albums. As a control condition, we measured the
number of reproductive messages in randomly selected songs from the same album by the
same vocalists that did not make it into the Top 10. As a result, each...
Examples ranged from gory low-budget horror to the sexploitation
ﬁlms of Russ Meyer. Elements of independent ‘exploitation’ strategy
were also embraced by Hollywood in its more mainstream, blockbuster
productions, especially the strategy of combining wide opening release
patterns with saturation advertising, in order to recoup costs quickly.
A number of Hollywood’s biggest-grossing ﬁlms of the 1970s were, in
part, bigger-budget and glossier versions of independent exploitation
fare, especially The Exorcist (1973) and Jaws (1975)....