Teratogenesi

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  • Define teratogenesis, mutagenesis, and carcinogenesis. • Describe the relevance of replication, transcription, and translation to teratogenesis, mutagenesis, and carcinogenesis. • Summarize the mechanism of action for teratogenesis, mutagenesis, and carcinogenesis. • Discuss examples of known teratogens, mutagens, and carcinogens.

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  • Valproic acid, a widely used anticonvulsant drug, is a potent teratogen resulting in various congenital abnormalities. However, the mechanisms underlying valproic acid induced teratogenesis are nor clear. Recent studies indicate that histone deacetylase is a direct target of valproic acid. Methods: In the present study, we have used histological analysis and RT-PCR assays to examine the cardiac abnormalities in mice treated with sodium valproate (NaVP) and determined the effects of NaVP on histone deacetylase activity and the expression...

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  • Learners enrolled in all healthcare training programs need to have a basic understanding of medical genetics so that they can successfully transition from students to clinicians. The field of medical genetics is advancing at a fast pace and is becoming increasingly integral to all aspects of medicine. This fact emphasizes the need for every practicing clinician and faculty member to develop an in-depth knowledge of the principles of human genetics, given that they are applicable to such a wide variety of clinical presentations.

    pdf249p bachduong1311 07-12-2012 19 4   Download

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