Xem 1-20 trên 108 kết quả Thalassemia disorders
  • Classes There are five major classes of hemoglobinopathies (Table 99-1). Structural hemoglobinopathies occur when mutations alter the amino acid sequence of a globin chain, altering the physiologic properties of the variant hemoglobins and producing the characteristic clinical abnormalities. The most clinically relevant variant hemoglobins polymerize abnormally, as in sickle cell anemia, or exhibit altered solubility or oxygen-binding affinity. Thalassemia syndromes arise from mutations that impair production or translation of globin mRNA, leading to deficient globin chain biosynthesis.

    pdf5p thanhongan 07-12-2010 27 4   Download

  • Epidemiology Hemoglobinopathies are especially common in areas in which malaria is endemic. This clustering of hemoglobinopathies is assumed to reflect a selective survival advantage for the abnormal RBC, which presumably provide a less hospitable environment during the obligate RBC stages of the parasitic life cycle. Very young children with αthalassemia are more susceptible to infection with the nonlethal Plasmodium vivax. Thalassemia might then favor a natural protection against infection with the more lethal P. falciparum.

    pdf5p thanhongan 07-12-2010 29 4   Download

  • Severity is highly variable. Known modulating factors are those that ameliorate the burden of unpaired α-globin inclusions. Alleles associated with milder synthetic defects and co-inheritance of α-thalassemia trait reduce clinical severity by reducing accumulation of excess α globin. HbF persists to various degrees in β-thalassemias. γ-Globin gene chains can substitute for βchains, generating more hemoglobin and reducing the burden of α-globin inclusions. The terms β-thalassemia major and β-thalassemia intermedia are used to reflect the clinical heterogeneity.

    pdf5p thanhongan 07-12-2010 28 3   Download

  • The homozygous state for the α-thalassemia-1 cis deletion (hydrops fetalis) causes total absence of α-globin synthesis. No physiologically useful hemoglobin is produced beyond the embryonic stage. Excess γ-globin forms tetramers called Hb Barts (γ4), which has a very high oxygen affinity. It delivers almost no O 2 to fetal tissues, causing tissue asphyxia, edema (hydrops fetalis), congestive heart failure, and death in utero. α-Thalassemia-2 trait is common (15–20%) among people of African descent. The cis α-thalassemia-1 deletion is almost never seen, however.

    pdf5p thanhongan 07-12-2010 32 3   Download

  • Hemoglobin E HbE (i.e., α2β226Glu - Lys) is extremely common in Cambodia, Thailand, and Vietnam. The gene has become far more prevalent in the United States as a result of immigration of Asian persons, especially in California, where HbE is the most common variant detected. HbE is mildly unstable but not enough to affect RBC life span significantly. The high frequency of the HbE gene may be a result of the thalassemia phenotype associated with its inheritance. Heterozygotes resemble individuals with mild β-thalassemia trait.

    pdf5p thanhongan 07-12-2010 37 3   Download

  • In an ideal world, marketing and sales create a shared go-to-market strategy that focuses on customers, not products. In this world, marketing creates demand with the right kinds of (profitable) prospects as well as promoting the brand, and sales has the insight and selling tools it needs to close those sales. This foundation of joint ownership and continuous information sharing is enabled by accessible and flexible technology.

    pdf11p doiroimavanchuadc 06-02-2013 34 12   Download

  • Researchers have theorized that anti-inflammatory medications may help prevent diseases, such as coronary artery diseases (CAD), cardio vascular diseases (CVD), stroke, colon cancer and Alzheimer’s. Several recent findings from different laboratories in the world employing case-control human studies and/or specific animal models for chronic human diseases support these ideas.

    pdf170p wqwqwqwqwq 23-07-2012 32 9   Download

  • Services’ Offi ce on Women’s Health and the Centers for Disease Control and Prevention’s National Center for Health Statistics as a tool to help identify vulnerable and underserved populations at the state level, where most decisions regarding health policy are developed and implemented. While the project provides data on health, health care, and risk behavior on all populations in each state for which data are collected, women’s health concerns have been targeted for inclusion, and racial and ethnic differences among women are a primary focus.

    pdf0p le_minh_nha 18-12-2012 27 8   Download

  • The Prostate Risk Indicator (www.prostatecancer-riskcalculator.com) was developed in Rotterdam and consists of 4 risk calculators, of which the first 3 predict the probability of detecting a prostate cancer (van den Bergh et al. 2008). This nomogram is based on 6288 Dutch men enrolled in the European Randomised Study of Screening for Prostate Cancer (ERSPC) (Schroder et al. 2009). The risk calculator comprises 4 risk indicators, the first 3 of which predict the possibility of a positive prostate biopsy.

    pdf198p ti_du_hoang 10-08-2012 46 7   Download

  • Currently, one of the most established and widely accepted stem cell bank systems is umbilical cord blood banking. However, the establishement of somatic stem cell bank other than cord blood (non-hematopoietic stem cells) is still underway. The nature of somatic stem/progenitor cells is much different from that of embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. Somatic stem/progenitor cells possess limited ability to differentiate compared with ES cells and iPS cells.

    pdf200p kmkmkmkmkm 08-09-2012 32 7   Download

  • Our results suggest that both monetary policy and capital inows shocks have a signicant and positive effect on house prices, credit to the private sector and residential investment. The effects of both shocks are greater in countries with a higher degree of mortgage market development, with the effect of monetary policy shocks roughly doubling. This suggests that excessive nancial innovation may act as a propagation mechanism. The existence of mortgage-backed securities has a much larger effect on the transmission of capital inows shocks.

    pdf41p taisaovanchuavo 23-01-2013 27 7   Download

  • The sixth and last part of the book, considers developments at the international level within the context of the World Trade Organization (WTO). It sets out the current state- of-play within WTO and alternate modalities for scheduling WTO commitments within the insurance sector, and ends with the chairman’s summary of the meeting which encapsulates discussions in all areas but focuses on the impact of insurance liberalization on developing countries.

    pdf0p thangbienthai 27-11-2012 17 6   Download

  • The impact that physical and psychological violence have on the health of an older person is exacerbated by the ageing process and diseases of old age. It is more difficult for the elderly to leave an abusive relationship or to make correct decisions because of the physical and cognitive impairments that usually come with old age. In some places, kinship obligations and the use of the extended family network to resolve difficulties may also lessen the ability of older people, particularly women, to escape from dangerous situations.

    pdf24p thankinhphanliet 01-01-2013 28 6   Download

  • Amplify: Use your social media activity to create awareness for and amplify your content housed in other places. This can go for teasing some aspect of your latest blog post on Twitter or in your Facebook status, creating full-blown events on Eventful or Meetup, or pointing to mentions of your firm in the media. If you publish a biweekly newsletter, in addition to sending it to your subscribers, archive it online and Tweet about it too. You can also add social features to your newsletter to make it very easy for others to retweet (tweetmeme button) and share on social...

    pdf94p lenh_hoi_xung 21-02-2013 18 6   Download

  • Models are an initial useful starting point and can assist in a more structured and ordered approach to the planning of events. There is no one model which fits all. It is for the event organizer to perhaps select and engage with a model he / she finds useful, and one which they can understand, share with their colleagues / stakeholders and add to or detract from. These models are not set in stone, they need to be reviewed, but they may well assist as a reference point. As a visual representation of the key areas of the event planning...

    pdf0p nhacchovina 22-03-2013 24 6   Download

  • In February of 2011, the Melman boys were at it again opening Paris Club and Studio Paris in Chicago’s River North neighborhood solidifying the already known truth that they too had a knack for opening and operating hot new restaurants. The menu, created by Chef Jean Joho is approachable French dining in a casual urban setting. Upstairs is Studio Paris, one of Chicago’s hottest nightlife destinations.

    pdf60p loginnhanh 25-04-2013 30 6   Download

  • The paper examines the origins of Paediatrics in Spain since 1600. It mentions some of the main pioneers for the speciality highlighting the role of, among others, Jerónimo Soriano, considered the forefather of the speciality in Spain. It looks at the factors that gradually contributed to the beginnings of Paediatrics as a specific branch, distinct from General Medicine and Obstetrics, explaining the slow but spectacular advances in Paediatrics to date.

    pdf562p wqwqwqwqwq 20-07-2012 26 5   Download

  • A further barrier to pension funds‟ investment in green projects is their lack of knowledge and experience not only with „green‟ projects, but with infrastructure investments in general (which green projects are often a subsector of) and the financing vehicles involved (such as private equity funds or structured products).

    pdf61p quaivatdo 19-11-2012 23 5   Download

  • in the united states, RREEF Real Estate’s engineering procedures include detailed practices to improve resource efficiency and environmental practices. the engineering team is deeply involved both in acquisitions due diligence, and in working closely with asset management to develop sustainable property management guidelines with third- party property managers.

    pdf0p quaivattim 01-12-2012 20 5   Download

  • The reverse is true of collection agencies, which provide information to the repositories, but do not use credit data to evaluate consumer creditworthiness, although they may use information in credit reports to locate debtors. Repositories also obtain information by requesting it from public records and government entities and when certain government entities report directly to the repositories, such as for delinquent child or family support payments, unpaid parking tickets, or overpayments of unemployment benefits.

    pdf44p enterroi 01-02-2013 23 5   Download

Đồng bộ tài khoản