The discovery of RNA interference (RNAi) generated considerable interest
in developing short interfering RNAs (siRNAs) for understanding basic
biology and as the active agents in a new variety of therapeutics. Early
studies showed that selecting an active siRNA was not as straightforward
as simply picking a sequence on the target mRNA and synthesizing the
siRNA complementary to that sequence.
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Potential therapeutic application of gold nanoparticles in B-chronic lymphocytic leukemia (BCLL): enhancing apoptosis
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications
The sixth edition of Modern Pharmacology With
Clinical Applications continues our commitment
to enlisting experts in pharmacology to provide
a textbook that is up-to-date and comprehensive. Designed
to be used during a single semester, the book focuses
on the clinical application of drugs within a context
of the major principles of pharmacology. It is meant
to serve students in medicine, osteopathy, dentistry,
pharmacy, and advanced nursing, as well as undergraduate
The collected Chapters in this volume describe the current status of poly(ethylene
glycol) (PEG) modification of proteins, peptides, oligonucleotides and
small molecule drugs, the recent advances in conjugation chemistry, and new
clinical products. The book provides an excellent update in this rapidly evolving
field, and the comprehensive collection of Chapters complements well past
reviews/volumes that have documented the evolution of PEGylation. For
example, a reader new to this field is encouraged to gain the historical perspective
by reading the following reviews [1–8].
This book describes the evidence behind the application of Therapeutic Hypothermia on patients with injury to the brain and spinal cord, that includes ischemia reperfusion after cardiac arrest or asphyxiation, traumatic brain injury, acute ischemic stroke, hemorrhagic stroke, refractory intracranial hypertension, cerebral edema in acute liver failure, subarachnoid hemorrhage, as well as spinal cord injury.
Applications that use HTML-based front ends benefit from
the pervasive distribution of Web browsers for universal, cross-platform
access. Another striking advantage of Web delivery lies in the concept of
thin clients and centralized maintenance, facilitating instantaneous deployment
of software updates at minimal cost. While the popularity of the
Web and its advantages as a client-server platform have led to countless
HTML-based applications, the development of Web applications is still
mostly ad hoc.
The ACR considers adherence to these guidelines and recommendations to be voluntary, with the ultimate determination regarding their application to be made by the physician in light of each patient’s individual circumstances. Guidelines and recommendations are intended to promote beneficial or desirable outcomes but cannot guarantee any specific outcome.
This book presents a collection of recent and extended academic works in selected topics of biomedical technology, biomedical instrumentations, biomedical signal processing and bio-imaging. This wide range of topics provide a valuable update to researchers in the multidisciplinary area of biomedical engineering and an interesting introduction for engineers new to the area. The techniques covered include modelling, experimentation and discussion with the application areas ranging from bio-sensors development to neurophysiology, telemedicine and biomedical signal classification....
Harrison's Internal Medicine Chapter 66. Stem Cell Biology
Stem Cell Biology: Introduction
Stem cell biology is a relatively new field that explores the characteristics and possible clinical applications of the different types of pluripotential cells that serve as the progenitors of more differentiated cell types. In addition to potential therapeutic applications (Chap. 67), patient-derived stem cells can also provide disease models and a means to test drug effectiveness.
In the last section on ‘Other Types of Viral Vector’, chapter sixteen introduces the
development of HIV vector pseudotyped with HIV envelope, and applications of these
vectors for AIDS or adult T-cell leukemia. Chapter seventeen introduces the
development of novel vector system for highly efficient retrograde gene transfer by
pseudotyping the HIV-1 vector with fusion glycoprotein B type (FuG-B). Herpes
simplex virus type 1 (HSV-1) is a human pathogen associated with keratitis and cold
This chapter describes the physiological role and pathophysical consequences of histamine release
and provides a summary of the therapeutic use of histamine H1-receptor antagonists. H2-receptor
antagonists are discussed in detail in Chapter 37: Agents Used for Control of Gastric Acidity and
Treatment of Peptic Ulcers and Gastroesophageal Reflux Disease in the context of prevention and
treatment of peptic ulcers, their principal therapeutic application.
The modular producer cell lines present several advantages: they are safer since integration
of the vector within the packaging cell line was identified, the duration of the entire
development process is much reduced as there is no need for screening and, in addition,
production conditions are favorable due to the possibility of pre-adaptation of the master
cell line to culture conditions and media. Thus, therapeutic virus production from bench to
bedside becomes safer, faster, and cheaper (Coroadinha et al. 2010)....
These criteria are
classified into its safety profile, performance within the GI tract and technological
aspects of its development. The criteria are further dependent on the specific purpose
of the strain and on the location for the expression of the specific property. With
regards to safety, the probiotic strain must be of human origin, isolated from the
gastrointestinal tract (GIT) of healthy individuals.
There was a need to bring
this information together in a single volume, as much of the key recent developments
have been dispersed throughout the biomedical literature, largely in specialized
journals. Since, as in the past, important developments in immunosuppressive
therapy in one branch of medicine (i.e. transplantation) are likely to benefit another
The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is
utilized by a range of cytokines (interferons, IL-2 and IL-6 amongst others) that control
survival, proliferation and differentiation responses in diverse cell types. The realisation that
unregulated activation of this pathway is a key driver of not only chronic inflammatory
diseases such as rheumatoid arthritis, colitis and psoriasis, but also many cancers has
identified its components as targets for therapeutic intervention by small molecule
inhibitors and biologicals.
This book has an aim to present latest applications, trends and developments of virtual reality technologies in three humanities disciplines: in medicine, psychology and pedagogy. Studies show that people in both educational as well as in the medical therapeutic range expect more and more that modern media are included in the corresponding demand and supply structures. For the Internet and various mobile media, associated research and application projects now have fixed key words such as "E-learning" and "E-Mental Health" or "M-Learning", "M-Mental Health"....
Several hematopoietic growth factors (HGFs) have achieved widespread clinical
application. In the United States alone, more than US $5 billion per year of the health care
budget is spent on these factors. The first patients were treated with recombinant human
erythropoietin (rHuEPO, epoetin alfa, Epogen®) in 1985 and the first patients received
recombinant methionyl human granulocyte colony-stimulating factor (r-metHuG-CSF,
filgrastim, Neupogen®) or recombinant human granulocyte-macrophage colonystimulating
factor (rHuGM-CSF, sargramostim, Leukine® or Prokine®) in 1986.
Pharmacology can be defined as the study of substances that interact with living systems through
chemical processes, especially by binding to regulatory molecules and activating or inhibiting
normal body processes. These substances may be chemicals administered to achieve a beneficial
therapeutic effect on some process within the patient or for their toxic effects on regulatory
processes in parasites infecting the patient.