Therapeutic drugs

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  • Introduction: Propionic acid derivative analgesic-antipyretics ( Table 2.1) are non-steroidal and antiinflammatory drugs. As one of mechanisms of their pharmacological actions, inhibition of prostaglandin biosynthesis can be mentioned. Although fatal cases due to propionic acid derivative analgesic-antipyretics are not many in the world, the incidence of poisoning (including survived cases) by this drug group is relatively high among therapeutic drugs in Japan [1].

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Safety concerns on the development of novel therapeutic drugs...

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Computerized clinical decision support systems for therapeutic drug monitoring and dosing: A decision-maker-researcher partnership systematic review

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  • Numerous studies have compared the outcomes of two competing interventions for multivessel coronary artery disease: coronary-artery bypass grafting (CABG) and coronary stenting. However, little information has become available since the introduction of drug-eluting stents.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Are we ready for therapeutic drug monitoring of biologic therapeutics?

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  • Foreword: It was with great pleasure that I accepted the invitation to write the foreword for Drugs and Poisons in Humans. A Handbook of Practical Analysis. Dr. Osamu Suzuki and Dr. Mikio Yashiki, two outstanding Japanese scientists, fi rst published the Handbook in Japanese in 2002. Specialists throughout Japan contributed analytical methods for a wide variety of therapeutic and illicit drugs, pesticides, and natural toxins and alkaloids. In fact, rarely has such a wide spectrum of analytes and metabolites been addressed within a single reference manual....

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  • The discovery of efficacious new human therapeutic agents is one of humanity’s most vital tasks. It is an enormously demanding activity that requires creativity, a vast range of scientific knowledge, and great persistence. It is also an exceedingly expensive activity. In an ideal world, no education would be complete without some exposure to the ways in which new medicines are discovered and developed. For those young people interested in science or medicine, such knowledge is arguably mandatory....

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  • Introduction: Benzodiazepines show antianxiety, hypnotic, anticonvulsant and muscle-relaxant effects. This group of drugs has wide safety dose ranges; it means that the ratio of the LD50 to the ED50 (therapeutic index) is high. Because of its safety, benzodiazepines are being widely used in the world. Some of benzodiazepines are also being abused or used for so-called “drug facilitated sexual assault”, and thus they are under the control of the Narcotics and Psychotropics Control Law; in Japan, triazolam abuse has become one of the serious social problems.

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  • Now in its fifth edition, this best-selling, multidisciplinary textbook continues to draw on the skills of pharmacists and clinicians to present optimal drug regimens. The authors integrate an understanding of the disease processes with an appreciation of pathophysiological processes, clinical pharmacy and the evidence base.

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  • Today, cancer research is focused on determining how genome and proteome level information may be useful as tools in prevention, diagnosis, and prognosis. The development of “omics” technologies, such as proteomics and transcriptomics has opened new research areas for scientists working on cancer research.

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  • Harrison's Internal Medicine Chapter 56. Cutaneous Drug Reactions CUTANEOUS DRUG REACTIONS: INTRODUCTION Cutaneous reactions are among the most frequent adverse reactions to drugs. Every physician will see patients suffering from them. Most are benign, but a few can be life-threatening. Prompt recognition of severe reactions, drug withdrawal, and appropriate therapeutic interventions can minimize toxicity.

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  • The publication Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book) identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration (FDA) under the Federal Food, Drug, and Cosmetic Act (the Act). (For more information, see the Orange Book Preface.)

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  • Discovery of a new chemical entity that exerts pharmacological effects for curing or treating diseases or relieving symptoms is only the first step in the drug developmental process. In the developmental cycle of a new drug, the delivery of a desired amount of a therapeutic agent to the target at a specific time or duration is as important as its discovery. In order to realize the optimal therapeutic outcomes, a delivery system should be designed to achieve the optimal drug concentration at a predetermined rate and at the desired location....

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  • Hypertension and Chronic Kidney Disease: Cause and Consequence – Therapeutic Considerations 45 Elsa Morgado and Pedro Leão Neves Potassium-Sparing Diuretics in Hypertension 67 Cristiana Catena, GianLuca Colussi and Leonardo A. Sechi Hypertension and Renin-Angiotensin System Roberto de Barros Silva Pharmacokinetic Interactions of Antihypertensive Drugs with Citrus Juices 95 Yoshihiro Uesawa Drug Interaction

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  • Description: Identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration under the Federal Food, Drug, and Cosmetic Act.

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  • Preclinical drug development. Discovery of new drugs in the laboratory is an exercise in prediction • Techniques of discovery. Sophisticated molecular modelling allows precise design of potential new therapeutic substances and new technologies have increased the rate of development of potential medicines. Studies in animals and in humans Prediction. Failures of prediction occur and a drug may be abandoned at any stage, including after marketing. New drug development is a colossally expensive and commercially driven activity. ...

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  • We must be daring and search after Truth; even if we do not succeed in finding her, we shall at least come closer than we are at present (Galen AD 130-200) SYNOPSIS (CONTINUED) Surveillance studies and the reporting of spontaneous adverse reactions respectively determine the clinical profile of the drug and detect rare adverse events. Further trials to compare new medicines with existing medicines are also required.These form the basis of cost-effectiveness comparisons.

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  • Herbs and traditional medicines are being extensively used for healthcare in almost all the countries since times immemorial. Ancient religious texts are replete with references on the use of natural products with medicinal properties. Because of local beliefs and practices and also from cost considerations herbal medicines remain a popular mode of treatment in the developing countries. Even in the industrialised society the rising cost of prescription drugs and ensuing side effects of the treatment make it highly attractive to use the traditional medicine particularly for minor ailments....

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  • The sixth edition of Modern Pharmacology With Clinical Applications continues our commitment to enlisting experts in pharmacology to provide a textbook that is up-to-date and comprehensive. Designed to be used during a single semester, the book focuses on the clinical application of drugs within a context of the major principles of pharmacology. It is meant to serve students in medicine, osteopathy, dentistry, pharmacy, and advanced nursing, as well as undergraduate students.

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  • Background Definitions Causation: degrees of certainty Pharmacovigilance and pharmacoepidemiology Classification Causes Allergy in response to drugs Effects of prolonged administration: chronic organ toxicity Adverse effects on reproduction Background Cur'd yesterday of my disease I died last night of my physician.1 Nature is neutral, i.e. it has no 'intentions' towards humans, though it is often unfavourable to them.

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