Propionic acid derivative analgesic-antipyretics ( Table 2.1) are non-steroidal and antiinflammatory drugs. As one of mechanisms of their pharmacological actions, inhibition of prostaglandin biosynthesis can be mentioned. Although fatal cases due to propionic acid derivative analgesic-antipyretics are not many in the world, the incidence of poisoning (including survived cases) by this drug group is relatively high among therapeutic drugs in Japan .
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Safety concerns on the development of novel therapeutic drugs...
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Are we ready for therapeutic drug monitoring of biologic therapeutics?
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Computerized clinical decision support systems for therapeutic drug monitoring and dosing: A decision-maker-researcher partnership systematic review
Numerous studies have compared the outcomes of two competing interventions for
multivessel coronary artery disease: coronary-artery bypass grafting (CABG) and
coronary stenting. However, little information has become available since the introduction
of drug-eluting stents.
(BQ) Part 2 book "Wallach's interpretation of diagnostic tests" presents the following contents: Renal disorders, respiratory, metabolic and acid–base disorders, toxicology and therapeutic drug monitoring, transfusion medicine, laboratory tests, infectious disease assays.
(BQ) Part 2 book "Prescribing at a glance" presentation of content: Logistics of prescribing (How to write a drug prescription, communicating with patients about medicines, therapeutic drug monitoring, avoiding drug interactions,...), specific drug groups (using drugs for the respiratory system, using drugs for the neurological system I, using drugs for infection, an approach to common prescribing requests,...).
(BQ) Part 1 book "Clinical chemistry - Quality in laboratory diagnosis" presents the following contents: Specimen receiving and processing, core chemistry, therapeutic drug monitoring/toxicology, point-of-Care testing.
Foreword: It was with great pleasure that I accepted the invitation to write the foreword for Drugs
and Poisons in Humans. A Handbook of Practical Analysis. Dr. Osamu Suzuki and Dr. Mikio
Yashiki, two outstanding Japanese scientists, fi rst published the Handbook in Japanese in 2002.
Specialists throughout Japan contributed analytical methods for a wide variety of therapeutic
and illicit drugs, pesticides, and natural toxins and alkaloids. In fact, rarely has such a wide
spectrum of analytes and metabolites been addressed within a single reference manual....
The discovery of efficacious new human therapeutic agents is one of humanity’s most vital
tasks. It is an enormously demanding activity that requires creativity, a vast range of scientific
knowledge, and great persistence. It is also an exceedingly expensive activity. In an
ideal world, no education would be complete without some exposure to the ways in which
new medicines are discovered and developed. For those young people interested in science
or medicine, such knowledge is arguably mandatory....
Now in its fifth edition, this best-selling, multidisciplinary textbook continues to draw on the skills of pharmacists and clinicians to present optimal drug regimens. The authors integrate an understanding of the disease processes with an appreciation of pathophysiological processes, clinical pharmacy and the evidence base.
Benzodiazepines show antianxiety, hypnotic, anticonvulsant and muscle-relaxant effects. This group of drugs has wide safety dose ranges; it means that the ratio of the LD50 to the ED50 (therapeutic index) is high. Because of its safety, benzodiazepines are being widely used in the world. Some of benzodiazepines are also being abused or used for so-called “drug facilitated sexual assault”, and thus they are under the control of the Narcotics and Psychotropics Control Law; in Japan, triazolam abuse has become one of the serious social problems.
Today, cancer research is focused on determining how genome and proteome level
information may be useful as tools in prevention, diagnosis, and prognosis. The
development of “omics” technologies, such as proteomics and transcriptomics has
opened new research areas for scientists working on cancer research.
Harrison's Internal Medicine Chapter 56. Cutaneous Drug Reactions
CUTANEOUS DRUG REACTIONS: INTRODUCTION
Cutaneous reactions are among the most frequent adverse reactions to drugs. Every physician will see patients suffering from them. Most are benign, but a few can be life-threatening. Prompt recognition of severe reactions, drug withdrawal, and appropriate therapeutic interventions can minimize toxicity.
The publication Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book) identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration (FDA) under the Federal Food, Drug, and Cosmetic Act (the Act). (For more information, see the Orange Book Preface.)
Discovery of a new chemical entity that exerts pharmacological effects for
curing or treating diseases or relieving symptoms is only the first step in
the drug developmental process. In the developmental cycle of a new
drug, the delivery of a desired amount of a therapeutic agent to the target
at a specific time or duration is as important as its discovery. In order
to realize the optimal therapeutic outcomes, a delivery system should
be designed to achieve the optimal drug concentration at a predetermined
rate and at the desired location....
Hypertension and Chronic Kidney Disease: Cause and Consequence – Therapeutic Considerations 45 Elsa Morgado and Pedro Leão Neves Potassium-Sparing Diuretics in Hypertension 67 Cristiana Catena, GianLuca Colussi and Leonardo A. Sechi Hypertension and Renin-Angiotensin System Roberto de Barros Silva Pharmacokinetic Interactions of Antihypertensive Drugs with Citrus Juices 95 Yoshihiro Uesawa Drug Interaction
(BQ) Part 1 book "Cardiovascular diseases - From molecular pharmacology to evidence-Based therapeutics" presents the following contents: General introduction, dyslipidemias, hypertension and multitasking cardiovascular drugs.
Preclinical drug development. Discovery of new drugs in the laboratory is an exercise in prediction • Techniques of discovery. Sophisticated molecular modelling allows precise design of potential new therapeutic substances and new technologies have increased the rate of development of potential medicines. Studies in animals and in humans Prediction. Failures of prediction occur and a drug may be abandoned at any stage, including after marketing. New drug development is a colossally expensive and commercially driven activity. ...