In this important book, Erving Polster - coauthor of the landmark work "Gestalt Therapy Integrated" - greatly expands the therapeutic utility of the concept of self. A Population of Selves offers therapists new ways of thinking about the self, as well as specific procedures to help patients realize a powerful and healthy sense of self: a goal at the very heart of the therapeutic process. In an innovative expansion of therapeutic theory, Polster shows how the human reflex to summarize and animate experiences serves as a natural springboard for the formation of selves.
Increasing physiological and psychological impairments with age does not mean that
ageing is equivalent with illness, diseases or dependency. In fact, earlier studies could not
explore that a type or the pathogenesis of diseases is only caused by the ageing process
(Steinhagen-Thiessen & Borchelt 1996). Brody and Schneider (1986) distinguished between
age-dependent and age-related diseases. Age-dependent diseases are involved in the ageing
process and cause the exponentially increasing mortality risk with advanced age, for instance
heart and cerebrovascular diseases.
There is an urgent need to develop new innovative therapies for the control of advanced cancer. The combination of antigen-specific immunotherapy with the employment of immunomodulatory agents has emerged as a potentially plausible approach for the control of advanced cancer. Methods: In the current study, we explored the combination of the DNA vaccine encoding calreticulin (CRT) linked to human papillomavirus type 16 (HPV-16) E7 antigen (CRT/E7) with the TLR7 agonist imiquimod for their ability to generate E7-specific immune responses and antitumor effects in tumor-bearing mice.
The title Perspectives on Complementary and Alternative Medicine was chosen for this
book to reflect the need for a critical overview of the subject areas that relate to the
development of complementary and alternative medicine (CAM) as part of a dynamic
process of change in contemporary society. The recent changes and developments in and
the exponential growth of CAM are explored from a wide range of perspectives and
covering several academic disciplines.
In this paper, we assess whether boosting minority car-ownership rates would narrow inter-
racial employment rate differentials. We pursue two empirical strategies. First, we explore whether
the effect of auto ownership on the probability of being employed is greater for more spatially
isolated groups of workers. The literature on racial housing segregation clearly demonstrates that
blacks are highly segregated from the majority white population (Massey and Denton, 1993) and in
a manner that spatially isolates blacks from new employment opportunities (Stoll et. al. 2000).
Harrison's Internal Medicine Chapter 66. Stem Cell Biology
Stem Cell Biology: Introduction
Stem cell biology is a relatively new field that explores the characteristics and possible clinical applications of the different types of pluripotential cells that serve as the progenitors of more differentiated cell types. In addition to potential therapeutic applications (Chap. 67), patient-derived stem cells can also provide disease models and a means to test drug effectiveness.
Isolated blunt abdominal trauma (BAT) represents about 5% of annual trauma mortality
from blunt trauma. As part of multiple-site injury (polytrauma), BAT contributes another
15% of trauma mortality. In the abdominal trauma, the best exploration strategy is one that
leads most quickly and reliably in the diagnosis of surgical injury. This strategy must be
established based on hemodynamic status and clinical guidance but should never delay a
An additional factor for lack of better therapeutic choices is the lack of suitable animal
models to replicate human glomerular injury in order to develop and test novel
treatment strategies. There are three detailed chapters that exemplify the recent
advances in using animal models to explore the pathogenesis of glomerulonephritis.
Immunopathogenic mechanisms in a murine model of membranous nephropathy are
discussed by Chia-Chao Wu et al., while autoimmune glomerulonephritis
complicating chronic graft versus host reaction was discussed by Elena Goiman et al....
Deep Soft-Tissue Infections: Treatment
Once necrotizing fasciitis is suspected, early surgical exploration is both diagnostically and therapeutically indicated. Surgery reveals necrosis and inflammatory fluid tracking along the fascial planes above and between muscle groups, without involvement of the muscles themselves. The process usually extends beyond the area of clinical involvement, and extensive debridement is required. Drainage and debridement are central to the management of necrotizing fasciitis; antibiotic treatment is a useful adjunct (Table 130-3), but surgery is lifesaving.
Stem cell biology is a relatively new field that explores the characteristics and possible clinical applications of the different types of pluripotential cells that serve as the progenitors of more differentiated cell types. In addition to potential therapeutic applications (Chap. 67), patient-derived stem cells can also provide disease models and a means to test drug effectiveness. Identification, Isolation, and Derivation of Stem Cells Resident Stem Cells The definition of stem cells remains elusive.
Cathelicidins are an important family of cationic host defense peptides in
vertebrates with both antimicrobial and immunomodulatory activities.
Fowlicidin-1 and fowlicidin-2 are two newly identified chicken cathelicidins
with potent antibacterial activities. Here we report structural and func-tional characterization of the putatively mature form of the third chicken
cathelicidin, fowlicidin-3, for exploration of its therapeutic potential.
Mutations in the alanine-glyoxylate aminotransferase gene (AGXT) are
responsible for primary hyperoxaluria type I, a rare disease characterized
by excessive hepatic oxalate production that leads to renal failure. A deeper
understanding of the changes in the metabolic pathways secondary to the
lack of AGXT expression is needed in order to explore substrate depletion
as a therapeutic strategy to limit oxalate production in primary hyperoxal-uria type I.
This study was undertaken to explore the potential of new therapeutic
approaches designed to reactivate cell death pathways in apoptosis-refrac-tory gliomas and to characterize the underlying molecular mechanisms of