During the last three decades, important advances have been made in the
available treatments for the loss of skeletal tissue as a result of trauma or
disease. The application of large skeletal allografts and total joint replacement
have become successful and reproducible treatment options. Unfortunately
there still is a significant incidence of failure because of mechanical or
The third edition of Principles of Tissue Engineering attempts to incorporate the latest advances in the biology and design of tissues and organs and simultaneously to connect the basic sciences — including new discoveries in the field of stem cells — with the potential application of tissue engineering to diseases affecting specific organ systems.
Current clinical technologies, especially donor transplants and artificial organs, have
been excellent life-saving and life-extending therapies to treat patients who need
to reconstitute diseased or devastated organs or tissues as a result of an accident,
trauma, and cancer, or to correct congenital structural anomalies. For long, most
scientists and clinicians believed that damaged or lost tissues could only be replaced
by organ transplantation or with totally artificial parts.
One of the main advantages of this technique is that it can produce the scaffold with main
structural feature suitable for growth of the cell and subsequent tissue organization (Li &
Tuan, 2009; Liang et al., 2007; Leong et al., 2008). It can produce the ultra fine fibers with
special orientation, high aspect ratio, high surface area, and having control over pore
Particulate leaching is one of the popular techniques that are widely used to fabricate
scaffolds for tissue engineering applications (Ma & Langer, 1999; Lu et al, 2000). Salt, wax or
sugars known as porogens are used to create the pores or channels. Here salt is grounded
into small particles and those particles that have desired size are poured into a mold and
filled with the porogen. A polymer solution is then cast into the salt-filled mold. After the
evaporation of the solvent, the salt crystals are leached away using water to form the pores
of the scaffold.
It is our pleasure to present this special volume on tissue engineering in the
series Advances in Biochemical Engineering and Biotechnology. This volume
reflects the emergence of tissue engineering as a core discipline of modern
biomedical engineering, and recognizes the growing synergies between the
technological developments in biotechnology and biomedicine. Along this
vein, the focus of this volume is to provide a biotechnology driven perspective
on cell engineering fundamentals while highlighting their significance in producing
Advances in stem cell biology and biomaterials development in the late 1990s have helped
drive on an ever expanding body of research in the field of tissue engineering and regenerative
medicine. Scientists realized that the key to future success of functional tissues is bridging the gap
between developmental biology and tissue engineering. We are all amazed by the high degree of
sophistication and miniaturization found in nature. Nature is, indeed, a school of science.
This book presents a collection of recent and extended academic works in selected topics of biomedical technology, biomedical instrumentations, biomedical signal processing and bio-imaging. This wide range of topics provide a valuable update to researchers in the multidisciplinary area of biomedical engineering and an interesting introduction for engineers new to the area. The techniques covered include modelling, experimentation and discussion with the application areas ranging from bio-sensors development to neurophysiology, telemedicine and biomedical signal classification....
This contribution book is a collection of reviews and original articles from eminent experts working in the multi- and interdisciplinary arena of biomaterials, ranging from their design to novel uses. From their personal experience, the readers can obtain a stimulating foresight on the potentialities of different synthetic and engineered biomaterials. 21 chapters have been organized to illustrate different aspects of biomaterials science.
The clinical microbiology laboratory is often a sentinel for the detection of drug resistant strains of microorganisms. Standardized protocols require continual scrutiny to detect emerging phenotypic resistance patterns. The timely notification of clinicians with susceptibility results can initiate the alteration of antimicrobial chemotherapy and improve patient care. It is vital that microbiology laboratories stay current with standard and emerging methods and have a solid understanding of their function in the war on infectious diseases. ...
One of the most awaited technologies for the preservation of tissue-engineered product is
long-term unfrozen storage (more specifically, dry storage) at ambient temperature. This
approach allows storage without dependence on expensive freezers or liquid nitrogen,
which require daily maintenance. This “off-the-shelf” availability and low cost should
facilitate the usage of tissue-engineered products. Unfortunately, this is not yet a reality.
It is my privilege to contribute the foreword for this unique volume entitled: “Plant
Tissue Culture Engineering,” edited by S. Dutta Gupta and Y. Ibaraki. While there have
been a number of volumes published regarding the basic methods and applications of
plant tissue and cell culture technologies, and even considerable attention provided to
bioreactor design, relatively little attention has been afforded to the engineering
principles that have emerged as critical contributions to the commercial applications of
Undergraduate biomedical engineering programs and curricula are being rapidly
developed across the United States. We perceive a correspondingly increasing
need for biomedical engineering textbooks specifically designed for undergraduate
readers. Many educators have come to appreciate that physiology and
biology are not narrow, specialized applications to be ‘‘tacked onto’’ an engineering
curriculum, but are instead rich subjects that can naturally elicit and
benefit from the kinds of creative problem-solving and quantitative analyses
that are hallmarks of engineering.
Since its first implementation by Lauterbur , Magnetic Resonance
Imaging (MRI) has become an important noninvasive imaging
modality. MRI has found a number of applications in the fields of
biology, engineering, and material science. Because it provides unique
contrast between soft tissues (which is generally superior to that of
CT) and high spatial resolution, MRI has revolutionized diagnostic
imaging in medical science. An important advantage of diagnostic MRI
as compared to CT is that the former does not use ionizing radiation....
The book "Applied Fracture Mechanics" presents a collection of articles on application of fracture mechanics methods to materials science, medicine, and engineering. In thirteen chapters, a wide range of topics is discussed, including strength of biological tissues, safety of nuclear reactor components, fatigue effects in pipelines, environmental effects on fracture among others. In addition, the book presents mathematical and computational methods underlying the fracture mechanics applications, and also developments in statistical modeling of fatigue.
Tissue Engineering is the first medical therapy where engineered tissues could
potentially become fully integrated within the patient, thus offering a permanent cure
for many diseases not curable today.
Nature has created numerous elegant living systems, including the human, based on the
hierarchical functional units—molecule, cell, tissue, and organ. A living system develops
through a long evolutionary process, during which the system undergoes genotypic and
phenotypic changes in response to environmental simuli.
This book will be of interest to anyone interested in the application of Tissue
Engineering. It offers a wide range of topics, including the use of stem cells and adult
stem cells, their applications and the development of a tailored biomaterial,
highlighting the importance of cell-biomaterial interaction. It offers insights into a wide variety of cells and biomaterials, explaining the groundwork required to open
the avenue to the next generation biotechnology, which is Tissue Engineering.
Polymer micromolding is a common way to ma
microchannels, because of the ease of processing, low co
and bio-compatibility. Molds with micron-scale featur
may be made from photosensitive polymers (e.g., SU-8)
by DRIE silicon micromachining. Poly(dimethylsiloxan
(PDMS) is often chosen as the microstructural materi
. PDMS is spin cast onto the mold, cured and peel
off. A short exposure in an oxygen plasma activates t
PDMS surface and results in instant bonding to oth
PDMS or glass surfaces.
The most important trend in biological engineering is the dynamic range of scales at
which biotechnology is now able to integrate with biological processes. An explosion
in micro/nanoscale technology is allowing the manufacture of nanoparticles for drug
delivery into cells, miniaturized implantable microsensors for medical diagnostics, and
micro-engineered robots for on-board tissue repairs. This book aims to provide an upto-
date overview of the recent developments in biological engineering from diverse
aspects and various applications in clinical and experimental research....