Toxicogenomic technologies

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  • Toxicogenomics has been described as a discipline combining ex- pertise in toxicology, genetics, molecular biology, and environmental health to elucidate the response of living organisms to stressful environ- ments. It includes the study of how genomes respond to toxicant expo- sures and how genotype affects responses to toxicant exposures. As the technologies for monitoring these responses rapidly develop, it is critical that scientists and regulators are confident that the technologies are reliable and reproducible and that the data analyses have been validated.

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  • In recent years, completion of the sequencing of the human genome as well as the genomes of dozens of other organisms and subsequent development of tools for comprehensive analysis of other cellular constituents have revolutionized biology. These new technologies, referred to broadly as “genomics,” have integrated biologic sciences with information sciences and engineering.

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  • Toxicogenomics has been described as a discipline combining ex- pertise in toxicology, genetics, molecular biology, and environmental health to elucidate the response of living organisms to stressful environ- ments. It includes the study of how genomes respond to toxicant expo- sures and how genotype affects responses to toxicant exposures. As the technologies for monitoring these responses rapidly develop, it is critical that scientists and regulators are confident that the technologies are reli- able and reproducible and that the data analyses have been validated.

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  • Tham khảo sách 'validation of toxicogenomic technologies: a workshop sumary', khoa học tự nhiên, công nghệ môi trường phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

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  • Toxicogenomics, the study of how genomes respond to exposure to toxi- cants, may ultimately hold the promise of detecting changes in the expres- sion of a person's genes if he or she is exposed to these toxicants. As the technology rapidly develops, it is critical that scientists and the public communicate about the promises and limitations of this new field. Commu- nicating technical information to the public about a developing science can be challenging, particularly when the applications of that science are not yet well understood.

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