Trisphosphate receptor

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  • Abstract Communication between the SR (sarcoplasmic reticulum, SR) and mitochondria is important for cell survival and apoptosis. The SR supplies Ca2+ directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close contacts between the two organelles referred to as mitochondrion-associated ER membrane (MAM). Although it has been demonstrated that CaR (calcium sensing receptor) activation is involved in intracellular calcium overload during hypoxia/reoxygenation (H/Re), the role of CaR activation in the...

    pdf11p toshiba23 18-11-2011 28 2   Download

  • Fluorescence ratio imaging indicates that immobilized, aspirin-treated platelets, loaded with Fura-2, respond to inositol 1,4,5-trisphosphate- (InsP3)-generating agonists such as thrombin by high-frequency, irregular rises in cytosolic [Ca 2+ ] i with spikes that vary in peak level and peak-to-peak interval. This differs from the regular [Ca 2+ ] i oscillations observed inother, larger cells.

    pdf10p research12 29-04-2013 17 1   Download

  • Sol Snyder, as you will learn from reading this collection of some of his bes scientific papers, is an immensely creative person—one of the most creativ in my generation of scientists. He has made numerous contributions to neu roscience and psychiatry that are not simply original, but often astonishingl so, because when they first appeared they were so audacious and unantic pated. Each of these discoveries has opened up a new area of understanding and together they have revolutionized the modern study of the brain....

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  • The production and further metabolism of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] require several calcium-dependent enzymes, but little is known about subsequent calcium-dependent changes in cellular Ins(1,4,5)P3.

    pdf11p media19 04-03-2013 18 1   Download

  • This review provides a comparative overview of recent developments in the modelling of cellular calcium oscilla-tions. A large variety of mathematical models have been developed for this wide-spread phenomenon in intra- and intercellular signalling. From these, a general model is extracted that involves six types of concentration variables: inositol 1,4,5-trisphosphate (IP3), cytoplasmic, endoplasmic reticulum and mitochondrial calcium, the occupied binding sites of calcium buffers, and the fraction of active IP3 receptor calciumrelease channels....

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