Abstract Communication between the SR (sarcoplasmic reticulum, SR) and mitochondria is important for cell survival and apoptosis. The SR supplies Ca2+ directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close contacts between the two organelles referred to as mitochondrion-associated ER membrane (MAM). Although it has been demonstrated that CaR (calcium sensing receptor) activation is involved in intracellular calcium overload during hypoxia/reoxygenation (H/Re), the role of CaR activation in the...
Fluorescence ratio imaging indicates that immobilized,
aspirin-treated platelets, loaded with Fura-2, respond to
inositol 1,4,5-trisphosphate- (InsP3)-generating agonists
such as thrombin by high-frequency, irregular rises in
i with spikes that vary in peak level and
peak-to-peak interval. This differs from the regular [Ca
oscillations observed inother, larger cells.
Sol Snyder, as you will learn from reading this collection of some of his bes
scientific papers, is an immensely creative person—one of the most creativ
in my generation of scientists. He has made numerous contributions to neu
roscience and psychiatry that are not simply original, but often astonishingl
so, because when they first appeared they were so audacious and unantic
pated. Each of these discoveries has opened up a new area of understanding
and together they have revolutionized the modern study of the brain....
The production and further metabolism of inositol 1,4,5-trisphosphate
[Ins(1,4,5)P3] require several calcium-dependent enzymes, but little is
known about subsequent calcium-dependent changes in cellular
This review provides a comparative overview of recent
developments in the modelling of cellular calcium oscilla-tions. A large variety of mathematical models have been
developed for this wide-spread phenomenon in intra- and
intercellular signalling. From these, a general model is
extracted that involves six types of concentration variables:
inositol 1,4,5-trisphosphate (IP3), cytoplasmic, endoplasmic
reticulum and mitochondrial calcium, the occupied binding
sites of calcium buffers, and the fraction of active IP3
receptor calciumrelease channels....