Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare and heterogeneous
neoplasms with overall increasing incidence, but not an associated increase in survival rate
over the past few decades. Tumors originate from at least 16 different cells of diffuse
endocrine system (DES), scattered through mucosa of gastrointestinal tract. They are mainly
sporadic, but sometimes exhibit familial inheritance.
One unsolved issue concerns the role of the clonal B-cell receptor (BCR) in disease
progression. Despite the fact that low expression of the BCR correlates with reduced
induction of protein tyrosine kinase activity and defective intracellular calcium mobilization
and tyrosine phosphorylation  this receptor conserves the capacity of antigen
recognition and signaling, controlling thereby key behaviors of tumor cell, like proliferation
and cell survival. Individual patients have different responses to IgM ligation which are
related to VH gene status.
We especially paid attention not to
distend the bladder too much to prevent a high irrigation pressure and a resultant TUR
syndrome. Special attention was paid to avoid the injury to Santorini’s plexus and the
rectum. The procedure was started from the 12 o’clock position, dividing the prostate into
6 parts, and resected specimens were collected separately to examine the distribution of
cancer. The seminal vesicle was partially resected at its attached part to the prostate
between the 4 and 8 o’clock positions to determine the invasion of cancer.
Over the period 2002-2007 the total net worth of all individual households increased by £430.3 billion
in2003, £431.1 billion in 2004, £475.8 billion in 2005, £504.9 billion in 2006 and £420.9 billion in 2007. In
2008 the net worth showed a dramatic loss of £841.2 billion, which equalled 58.7% of 2008 nominal GDP.
In the years to 2011 this loss has barely been recuperated, let alone that any growth path was created
identical to the 2002-2007 net worth improvements.
These gains and losses arise from both produced as well as financial assets.
Combined methods have led to further refinements
with, for example, high visuospatial resolution afforded by MRI combined with
metabolic information from the lesion site (measured with 18F-fluorodeoxyglucose
positron emission tomography; FDG-PET) to indicate location and malignancy of
gliomas, which in turn informs radiosurgical targeting. Kapsalaki et al. (Chapter 7)
consider MRS spectroscopic profiles for differentiation among ring enhancing lesions
including high grade gliomas, abscesses and post-radiation necrosis.
The health effects of violence against women are
serious, far-reaching, and intertwined. Health care
providers have the opportunity and the obligation to
identify cases of abuse. For many women in developing
countries, a visit to a health clinic for reproductive or child
health services may be their only contact with the health
care system. The health care sector can capitalize on this
opportunity by ensuring a supportive and safe environment
for clients, helping providers ask about abuse, and helping
women receive the care they need.
Property, plant and equipment is carried at cost less accumulated depreciation. Assets
manufactured by the Company include direct manufacturing costs, production overheads
and interest charges incurred during the construction period. Government grants are
deducted from the cost of the related asset. Depreciation is calculated using the
straight-line method over the expected economic life of the asset. Depreciation of special
tooling costs is based on the expected future economic benefit of these tools.
Your Marketing major will cover all the essential
components of marketing including consumer behaviour,
marketing management, strategy, research and analysis.
You’ll explore the strengths and weaknesses of many of the
theories on which the conventional approach to marketing
is based. You’ll also discover that marketing is not about
routinely applying a standard set of techniques but instead
about using knowledge and experience to give each issue
its own specific strategy.
ersonal “lives” were, generally not migrated into archives
because of their on-going nature although nearly all photos were treated as archival. The rationale was that
photos are fundamentally archives and this had to do with the mindset that Windows established by making
“My Pictures” a special folder, that would lead people to store all photos in one folder hierarchy. Most of
Bell’s photos are in a folder called “A Big Shoebox”. Over time, however, we also ended up storing photos
throughout the folder hierarchy because all items pertaining to a single subject, e.
A project has discrete steps budgeted into time, and it is in finite steps that
project management can go awry. Someone who has never run the kind of
project being detailed is likely to assign steps and values that are unrealistic.
Therefore, project management is best done by someone who has completed
a similar project before and knows the steps that go into it.
Like many management principles, project management isn’t new. Henry
Laurence Gantt, a mechanical engineer and disciple of scientific management
first published the Gantt chart in 1910.
The act of incorporating modern music into silent ﬁlm screenings is also not
without precedent outside of academia. Since 1982, Pordenone Italy has hosted
Le Giornate Del Cinema Muto, a silent ﬁlm festival that has regularly featured
contemporary scores written and performed by such composers as Wim Mertens
and John Cale.
13 In 1984, Giorgio Moroder compiled a modern rock score for a
theatrical re-release of Metropolis (Germany, 1928, Fritz Lang).
Despite a variety of processes and the availability of raw-material sources, the
widespread utilisation of annual plants in pulping has not been technically or
economically feasible in Western countries due to the lack of a simple and
environmentally efficient pulping method and the problems associated with raw
material storage and logistics.
An ideal non-wood pulping process is simple and environmentally efficient
and can be applied on a small scale.
Although substantial economic development and improvement of health services have
occurred, Asia is a heterogeneous and resource-constrained continent. Over half of the 50
million people with epilepsy worldwide are estimated to live in Asia (Mac et al., 2007).
There are some biological differences in epilepsy between Asia and the West, mainly related
to the young average age and smaller physique among Asians. This probably partly
explains the smaller doses of antiepileptic drugs found effective in some trials involving
Asians (Yang et al., 2007).
We approximate credit risk developments at the bank level by considering non-
performing loans of each institution and rating changes at the individual security level.
Importantly, our database allows us to identify not only the rating of these securities at the time
of origination but also their evolution over time. We also analyze to what extent housing prices,
securitization activity and lending may have asymmetric effects across institutions and
geographically (at the regional level) by identifying the role of each of these factors.
Until the early 1980s, banking was largely a local
business, reflecting the limits placed by the states
on intra- and interstate branching. At year-end
1977, 20 states allowed statewide branching, and
the remaining 30 states placed limits on intrastate
branching.17 However, as the benefits of geo-
graphic diversification became better understood,
many states began to lift the legal constraints on
branching. By mid-1986, 26 states allowed
statewide branch banking, while only 9 restricted
banks to a unit banking business. By 2002, only 4
states placed any limits on branching.
The different implications of high government debt and unsustainable public finances
should be reflected in prices for government securities. The existence and
implementation of the European fiscal framework should therefore have a twofold
effect. First, the credibility of the European fiscal framework and its ability to deter
“excessive” deficits and debt in the perception of market participants generally affect
future risks associated with liabilities of all member states.
Two commonly cited cross-country user-side data collection efforts are the FinMark
Trust’s FinScope initiative, a specialized household survey in 14 African countries
and the European Bank for Reconstruction and Development’s Life
in Transition Survey (LITS), which covers 35 countries in Europe and Central Asia
and includes several questions on financial decisions as part of a broader survey.
As indicated above, in some instances, the Commissioner may decide to utilise
powers conferred under section 24 of the Data Protection Acts and order an
inspection team comprised of authorised officers to arrive unannounced at the
premises of a particular data controller or data processor. In such cases, authorised
officers will carry official photo identification and a signed letter from the
Commissioner on logo-headed paper.
for software losses due to counterfeiting in the European Union was estimated to be
approximately $11 billion in 2006 compared with losses of $7.2 billion in the USA
(Business Software Alliance, 2007). A similar story is apparent for the film industry
with the Motion Picture Association of America reporting, through a survey of 22
countries, losses to its member studios of $6.1 billion in 2005, with $2.3 billion of that
being made up of internet piracy.
As new technologies emerge, the Federal government has a responsibility to lead by example. Our
government owns and manages approximately 500,000 buildings and operates more than 600,000
fleet vehicles. The electricity used for its buildings, the fuel used in its cars and trucks, and the
energy required in military operations make it the largest energy consumer in the US economy.