Uniqueness of cadasil

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  • Although this book is far from being exhaustive, it conveys some of the novel ideas and directions in the membrane trafficking field through a combination of review, research, and technical articles. The book is organized in a series of chapters that will “transport” the reader from the endoplasmic reticulum, where proteins and lipids are synthesized, to the plasma membrane, where molecules are either delivered or internalized via endocytosis.

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  • Cancer policy at that time was less well developed than it is today, but there had been both widespread concern and innovative thinking about the issues, particularly in relation to breast cancer. This was given an impetus by the implementation of the Breast Screening Programme in the late 80s and early 1990s, which challenged assumptions about the quality of care available for patients with symptomatic disease.

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  • Since it has been shown that car-sharing can contribute markedly to reducing the burden of automobile traffic on the environment, the Swedish National Road Administration considers it important that the establishment and growth of car- sharing schemes be enouraged. There is a need of clarifying, however, just what car-sharing is and what quality requirements should be met by car-sharing groups in order for public benefits and support to be provided them.

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  • It has been shown that under dehydration the function of camel kidneys is depressed, including a reduction in glomerular filtration rate from about 60 ml/100kg/min to 15 ml/100kg/min. When camels are allowed to drink immediately to satiation, the kidney function rapidly returns to normal. Within half an hour there is a significant increase in the urine flow rate, glomerular filtration rate and in kidney plasma flow, which are accompanied by significant decreases in plasma and urine osmolarities. ...

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  • But risk factors don’t tell us everything. Having a risk factor, or even several risk factors, does not mean that you will get the disease. And some people who get the disease may have few or no known risk factors. Even if a person with basal or squamous cell skin cancer has a risk factor, it is often very hard to know how much that risk factor may have contributed to the cancer. The following are known risk factors for basal cell and squamous cell carcinomas. (These factors don't necessarily apply to other forms of non-melanoma skin cancer, such as...

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  • Monitoring any portion of the Internet address space reveals incessant activity. This holds even when monitoring trafc sent to unused addresses, which we term “background radiation.” Background radiation reects fundamentally nonproductive trafc, either malicious (ooding backscatter, scans for vulnerabilities, worms) or benign (miscongurations). While the general presence of background radiation is well known to the network operator community, its nature has yet to be broadly characterized.

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  • Second, economic adjustment within the euro area is continuing. This is most visible in the reduction of large current-account deficits driven by partly permanent declines in domestic absorption and gains in competitiveness, but is also apparent in gradually rising wages and domestic demand in surplus countries. Internal and external adjustment has farther to go, and it will have to be sustained over time to see an impact on stocks of domestic and external liabilities.

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  • Two tests are available to screen for prostate cancer: prostate-specific antigen (PSA) and digital rectal examination (DRE). The first of these is a blood test, and the second is a physical examination by a doctor where a finger is passed into the rectum to directly feel for enlargement or a nodule in the prostate gland. The subsequent diagnostic test is a prostatic biopsy taken through the rectum. This paper will discuss the use of PSA as part of a screening program. In clinical practice DRE is used to supplement rather than replace PSA. Wilson and Jungner described a...

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  • In part, this small-scale sub-sector of poultry production has grown in response to a market demand for poultry that is raised using production systems outside of the conventional, confinement, industrial model. Free-range poultry, heritage poultry varieties, organic certification and other characteristics are used by farmers to distinguish their products and to help earn a margin that enables them to be profitable despite their small volume of production.

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  • Our notion of what triggers a boom-bust cycle is very stylized: the signal occurs on a particular date and people learn that it is exactly false on another particular date. In more realistic scenarios, people form expectations based on an accumulation of various signals. If people’s expectations are in fact overoptimistic, they come to this realization only slowly and over time.

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  • Another major role of marketing relates to change in ownership. Agricultural goods, like most other goods, have value only in terms of their usefulness -- utility -- to consumers. The pricing and exchange functions associated with possession are the heart of marketing. Pricing is the determination of market values in terms of money. Buyers and sellers at a given time agree on a common evaluation. Prices may vary from day to day or hour to hour, depending on demand and supply. But, in time, prices of different commodities seek different levels in accordance with...

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  • At this point in our industry’s evolution, it’s important to have government involvement. Incumbent technologies, such as internal combustion engines for transportation and the electrical power grid, have a huge head start and, in many cases, the rules of the game are written to support their continuation. Our society is comfortable with these technologies and has depended on them for many generations. Because we are not yet producing products at high volume, we are often faced with an initial cost disadvantage compared to traditional, less sustainable power generation methods.

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  • CP is normally issued with maturities of 270 days or less, though most CP has maturities of 90 days or under. Yields vary with maturity and credit quality, but CP normally offers a higher yield than Treasuries or agencies. Because CP has such a short maturity, the companies that issue it are almost constantly raising money in the market, rolling over or replacing CP that has just matured, as part of a commercial paper program. Since the CP market is generally open only to issuers with strong credit ratings, there have been few defaults over the years—but there have been some.

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  • Hollywood remains the principal source of funding and distribution, even when only a relatively small proportion of production is conducted entirely in-house. Technically independent productions include Hollywood blockbusters such as Terminator 2: Judgment Day (1991) and Basic Instinct (1992), produced by the independent Carolco in an alliance with TriStar Pictures.

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  • On April 11, 2012, several Planned Parenthood affiliates in Texas that provide only family planning services, not abortion, filed suit against Texas, alleging that their exclusion from the WHP violates the First Amendment’s guarantee of free speech and free association and the Fourteenth Amendment’s guarantee of equal protection, as well as state law. 41 On April 30, 2012, the district court granted a preliminary injunction that prevented the affiliate rule from taking effect.

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  • NO2 is a product of combustion. It is a precursor to ground-level ozone formation through photochemical reactions involving VOCs. NO2 causes a brown colour in the atmosphere at elevated concentrations. It reacts in the atmosphere with ammonia to form fine particulates, which reduce visibility and increase PM2.5 concentrations (Levelton Engineering Limited, 2000). NO2 irritates the mucous membranes in the respiratory tract.

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  • In implementing a programme of privatisation and restructuring, it should be recognised that the restructuring process, if left solely to the market forces, may create substantial unemployment and incur considerable social costs. Supporting a programme of careful restructuring by the creation of new business out of the old, engaging under-utilised assets, with or without an element of public subsidy, may add considerable value to local economies. The experience of the transitional economies in Europe shows the potential for creating small businesses out of large company restructuring.

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  • The StanMark project brings together researchers and policy‐makers to develop a set of standards for marketing foods and beverages consistent with the resolution of the World Health Assembly. Objectives Convene a series of meetings in Europe and the USA to bring together key members of the scientific research community and policy‐making community to consider how marketing food and beverages may affect children’s health.

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  • By converting wind energy into electricity,windturbines reduce the environmental impact of powergeneration.Wind energy is currently the mostdeveloped of a number of renewable energytechnologies,with more than 1,000 wind turbinesalready operating across the UK,producing around one quarter of one percent of the country’s energy.Wind turbines can be deployed individually,to power a single site or installation,but are most commonlygrouped together as ‘wind farms’to provide power to the national grid.

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  • Pathfinder and its partner organizations train and work with the WACs to help them become agents for social change, emphasizing the dangers of female genital cutting and early marriage and the importance and benefits of safer sexual behaviors, maternal and child health care, and family planning. Highly respected by their communities, WAC members are in a unique position to gain community trust and pave the way for CHWs to introduce their lessons and family planning methods. The WACs have embraced their role and have had great success in influencing change at the district level.

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