Shiga toxin can be internalized by clathrin-dependent endocytosis in differ-ent cell lines, although it binds specifically to the glycosphingolipid Gb3. It
has been demonstrated previously that the toxin can induce recruitment of
the toxin–receptor complex to clathrin-coated pits, but whether this process
is concentration-dependent or which part of the toxin molecule is involved
in this process, have so far been unresolved issues.
Parallel and distributed computing has offered the opportunity of solving a wide range
of computationally intensive problems by increasing the computing power of sequential
computers. Although important improvements have been achieved in this field in the last
30 years, there are still many unresolved issues. These issues arise from several broad areas,
such as the design of parallel systems and scalable interconnects, the efficient distribution of
processing tasks, or the development of parallel algorithms....
Fiscal policy, based on cash-budgeting, aims over the medium term at preserving fiscal sustainability, while allowing for some modest increase in infrastructure and social spending. Given the fiscal framework, Government finances have improved. There are, however, unresolved issues concerning ghost workers and the accounting for diamond revenues. Total revenue increased from US$933.6 million in 2009 to US$2.34 billion in 2010, underpinned by increases in income and corporate taxes.
It is incredible to think that although the founders of medical ethics,
such as Hippocrates, published their works more than 2000 years
ago, the medical profession, up until now, has not had a basic,
universally used, curriculum for the teaching of medical ethics. This
first WMA Ethics Manual aims to fill that void. What a privilege it is
to introduce it to you!
The Manual’s origin dates back to the 51st World Medical Assembly
This book focuses on the growing problems of governance in the
United States and on potential means of alleviating them. The prob-
lems are familiar: more single-issue politics and gridlock in Congress,
more breakdowns in administrative control and accountability within
the executive branch, and more litigation over public policy in the
courts—as well as persistently low levels of public trust in the federal
government since the 1960s. Relatively few Americans, however, have
appreciated the potential of community-based initiatives to help re-
solve some problems of governance.
Efforts to master the crisis have fallen short so far. Measures have been primarily
implemented at a national level, if they have been implemented at all. As in many other
countries, the bank rescue package in Germany has only been partially successful. The
package’s provisions for the sale of toxic assets have hardly been taken advantage of to
This book, with its 16 chapters, documents the present state of knowledge of the
adenosine A3 receptor. It covers a wide range of information, including data from
studies of theoretical, molecular and cellular pharmacology, signal transduction,
integrative physiology, new drug discoveries and clinical applications. It fills an
important gap in the literature since no alternative source of such information is
The Queensland Civil and Administrative Tribunal (QCAT) has the
power to hear tenancy disputes. If the RTA cannot help you resolve a
bond dispute, it will issue a Notice of Unresolved Dispute.
For bond disputes the person who receives a Notice of Unresolved
Dispute has seven days in which to apply to the Tribunal for a hearing
and notify the RTA. If the person does not apply to the Tribunal and
notify the RTA within seven days, the RTA will release the bond to the
other party, according to the fi rst Refund of Rental Bond form they