Validation methods

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  • The immediate reason for the creation of this book has been the advent of Basel II. This has forced many institutions with loan portfolios into building risk models, and, as a consequence, a need has arisen to have these models validated both internally and externally. What is surprising is that there is very little written that could guide consultants in carrying out these validations. This book aims to fill that gap.

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  • Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Robust video super resolution algorithm using measurement validation method and scene change detection

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  • Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Research Article Evaluation of a Validation Method for MR Imaging-Based Motion Tracking Using Image Simulation

    pdf11p dauphong15 18-02-2012 17 2   Download

  • Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientists present what has been accomplished thus far in developing acceptable alternatives to traditional animal toxicological assessment and provide potentially new initiatives.

    pdf617p cronus75 18-01-2013 25 5   Download

  • his monograph presents methods for full comparative distributional analysis based on the relative distribution. This provides a general integrated framework for analysis, a graphical component that simplifies exploratory data analysis and display, a statistically valid basis for the development of hypothesis-driven summary measures, and the potential for decomposition - enabling the examination of complex hypotheses regarding the origins of distributional changes within and between groups.

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  • Novice users engaged in task-oriented dialogues with an adviser to learn how to use an unfamiliar statistical package. The users', task was analyzed and a task structure was derived. The task structure was used to segment the dialogue into subdialogues associated with the subtasks of the overall task. The representation of the dialogue structure into a hierarchy of subdialogues, partly corresponding to the task structure, was validated by three converging analyses.

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  • This paper describes a COMIT program that proves the validity of logical arguments expressed in a restricted form of ordinary English. Some special features include its ability to translate an input argument into logical notation in four progressively refined ways, of which the first pertains to propositional logic and the last three to first-order functional logic; and its ability in many cases to select the "correct" logical translation of an argument, i.e., the translation that yields the simplest proof....

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  • The GIVE Challenge is a recent shared task in which NLG systems are evaluated over the Internet. In this paper, we validate this novel NLG evaluation methodology by comparing the Internet-based results with results we collected in a lab experiment. We find that the results delivered by both methods are consistent, but the Internetbased approach offers the statistical power necessary for more fine-grained evaluations and is cheaper to carry out.

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  • This paper addresses the problem of correcting spelling errors that result in valid, though unintended words (such as peace and piece, or quiet and quite) and also the problem of correcting particular word usage errors (such as amount and number, or among and between). Such corrections require contextual information and are not handled by conventional spelling programs such as Unix spell. First, we introduce a method called Trigrams that uses part-of-speech trigrams to encode the context. This method uses a small number of parameters compared to previous methods based on word trigrams.

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  • The main contents of this chapter include all of the following: Simulation modeling, random variables and pseudo-random numbers, time increments, experimental design, simulation applications, computer implementation, verification and validation, advantages and disadvantages of using simulation.

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  • This lecture will teach you how to fit nonlinear functions by using bases functions and how to control model complexity. The goal is for you to: Learn how to derive ridge regression; understand the trade-off of fitting the data and regularizing it; Learn polynomial regression; understand that, if basis functions are given, the problem of learning the parameters is still linear; learn cross-validation; understand model complexity and generalization.

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  • In a prior edition of this book the preface commenced with the paraphrase of an old adage in an era of evolving local area networking technology: Ethernet is dead—long live Ethernet! Although advances in communications technology continue to occur at a rapid pace, that paraphrase continues to be valid. Within the past decade, the bandwidth of 10 Mbps Ethernet was advanced by a factor of one thousandwith the introduction of a series of enhancements to the original Ethernet specification. First, Fast Ethernet resulted in the bandwidth of Ethernet increasing by a factor of 10 to 100 Mbps.

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  • As currently taught, the introductory course in analytical chemistry emphasizes quantitative (and sometimes qualitative) methods of analysis coupled with a heavy dose of equilibrium chemistry. Analytical chemistry, however, is more than equilib- rium chemistry and a collection of analytical methods; it is an approach to solving chemical problems. Although discussing different methods is important, that dis- cussion should not come at the expense of other equally important topics.

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  • The method validation process is to confirm that the method is suited for its intended purpose. Although the requirements of validation have been clearly documented by regulatory authorities [ICH, USP, and FDA], the approach to validation is varied and open to interpretation. Validation requirements differ during the development process of pharmaceuticals. The method validation methodologies in this chapter will focus on the method requirements for preliminary and full validation for both drug substance and drug product.

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  • Food safety is of great importance to consumers. To ensure the safety of the food supply and to facilitate international trade, government agencies and international bodies establish standards, guidelines, and regulations that food producers and trade partners need to meet, respect, and follow. A primary goal of national and international regulatory frameworks for the use of veterinary drugs, including antimicrobials, in food-producing animals is to ensure that authorized products are used in a manner that will not lead to non-compliance residues.

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  • eate a simple Visual Basic .NET-based application based on the Windows Application template. Use forms and controls to create a user interface. Create and use variables and arrays. Create and use Sub and Function procedures, including predefined functions. Implement decision structures and loops by using conditional expressions. Validate user input for fields, controls, and forms. Apply object-oriented programming techniques to create classes, add methods, and add properties.

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  • The current text deals with several, very important topics of modern, Analytical Chemistry, such as analytical method validation in biotechnology today, principal component analysis, kinetic methods of analysis using potentiometric and spectrophotometric detectors, the current status of Analytical Chemistry and where it may move in the future, peptide and amino acid separations and identification, and several other, related topics in this growing and increasingly important area of Chemistry, in general.

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  • HEIs that pass the audit receive a quality label and are added to the register of audited institutions maintained on FINHEEC’s website. The quality label is valid for six years from the Evaluation Council’s meeting at which the audit decision was made. The audit certificate related to the quality label explains whether the audit was carried out by a Finnish or an international audit team, provides a summary of the key findings and describes the optional audit target.

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  • Special and general relativity are the theories describing the physics of space and time. Space and time are explored with clocks and electromagnetic signals. Therefore, special and general relativity are related to precise clocks and the thorough understanding of signal propagation. The ever-increasing accuracy of clocks together with novel methods for precision time transfer and clock synchronization are pivotal for the new generation of experiments probing the validity of Einstein’s theories from subatomic distances to cosmic scales....

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  • The idea for this book originated during a conversation in December 2006 with C. Deborah Laughton, Publisher, Methodology and Statistics, at The Guilford Press, about the challenges of teaching research seminars or other courses in which students conduct a thesis project. These students could be senior undergraduates in advanced programs, such as honors or specialization, or first-year graduate students.

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