Ammodytoxins are neurotoxic secretory phospholipase A2molecules, some
of the most toxic components of the long-nosed viper (Vipera ammo-dytes ammodytes) venom. Envenomation by this and by closely related
vipers is quite frequent in southern parts of Europe and serotherapy is used
in the most severe cases.
Since the method of treating snakebite-poisoning by hypodermic injections of strychnine, discovered by the
writer and published but a few years ago, has already been adopted by the medical profession throughout the
Australian colonies, and practised even by laymen in cases of urgency with much success, it has been
repeatedly suggested to him that the subject calls for further elucidation at his hands; that the morbid
processes engendered by the snake venom and the modus operandi of the antidote should be explained by him
in a manner satisfying the demands of science, and at the same time wi...
The molecular mechanism of the presynaptic neurotoxicity
of snake venom phospholipases A2(PLA2s) is not yet fully
elucidated. Recently, newhigh-affinity binding proteins for
toxins have been discovered, including the important
sensor, calmodulin (CaM). In the present
study, the mode of interaction of group IIAPLA2swiththe
-bound form of CaM was investigated by mutational
analysis of ammodytoxin A (AtxA) from the long-nosed
viper (Vipera ammodytes ammodytes).