Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Understanding the impact of resistance and virulence factors on methicillin-resistant Staphylococcus aureus infections in the intensive care unit...
Tuyển tập các báo cáo nghiên cứu về bệnh thú y được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành thú y đề tài: Association Between Virulence Factors and Clinical Course of Escherichia coli Mastitis...
HP1286 fromHelicobacter pyloriis among the proteins that play a relevant
role in bacterial colonization and persistence in the stomach. Indeed, it was
demonstrated to be overexpressed under acidic stress conditions, together
with other essential virulence factors. Here we describe its crystal structure,
determined at 2.1 A˚ resolution.
Less than 3 decades ago, Robin Warren and Barry Marshall definitively identified Helicobacter pylori by culturing an organism from gastric biopsy specimens that had been visualized for almost a century by pathologists (196). In 1994, H. pylori was recognized as a type I carcinogen, and now it is considered the most common etiologic agent of infection-related cancers, which represent 5.5% of the global cancer burden (239). In 2005, Marshall and Warren were awarded the Nobel Prize of Medicine for their seminal discovery of this bacterium and its role in peptic ulcer disease
A well-developed knowledge of clinical microbiology is critical for the practicing physician in any medical field. Bacteria, viruses, and protozoans have no respect for the distinction between ophthalmology, pediatrics, trauma surgery, or geriatric medicine. As a physician you will be faced daily with the concepts of microbial disease and antimicrobial therapy.
The past three decades have witnessed a steadily
increasing awareness of the need to empower women
through measures to increase social, economic and
political equity, and broader access to fundamental
human rights, improvements in nutrition, basic health
and education. Along with awareness of the
subordinate status of women has come the concept of
gender as an overarching socio-cultural variable, seen
in relation to other factors, such as race, class, age and
We also demonstrate that optimal portfolios of mutual funds are in°uenced substantially
by prior beliefs about both managerial skill and pricing models. For example, consider two
investors who both rule out managerial skill but believe strongly in di®erent models: one
believes in the CAPM while the other embraces a four-factor model. If either investor is
forced to hold the portfolio chosen by the other, the resulting ex ante loss is about 60 basis
points per month in certainty equivalent return.
Enteric pathogens have developed a variety of tactics to overcome host defenses. Understanding the virulence factors employed by these organisms is important in the diagnosis and treatment of clinical disease.
The number of microorganisms that must be ingested to cause disease varies considerably from species to species. For Shigella, enterohemorrhagic Escherichia coli, Giardia lamblia, or Entamoeba, as few as 10–100 bacteria or cysts can produce infection, while 105–108Vibrio cholerae organisms must be ingested orally to cause disease.
Hib strains cause systemic disease by invasion and hematogenous spread from the respiratory tract to distant sites such as the meninges, bones, and joints. The type b polysaccharide capsule is an important virulence factor affecting the bacterium's ability to avoid opsonization and cause systemic disease.
Nontypable strains cause disease by local invasion of mucosal surfaces. Otitis media results when bacteria reach the middle ear by way of the eustachian tube. Adults with chronic bronchitis experience recurrent lower respiratory tract infection due to nontypable strains.
Given the spatial relationships extracted as described above, our
goal is to integrate this information into an optimization framework
with a properly deﬁned cost function quantifying the quality of the
furniture arrangement. Given an arbitrary room layout populated by
furniture objects, the synthesized arrangement should be useful for
virtual environment modeling in games and movies, interior design
software, and other applications.
The search space of our problem is highly complex as objects are
interdependent in the optimization process.
Pasteurella multocidatoxin (PMT) is a virulence factor responsible for the
pathogenesis of somePasteurellosis. PMT exerts its toxic effects through
the activation of heterotrimeric GTPase (Gq,G12⁄ 13 and Gi
pathways, by deamidating a glutamine residue in theasubunit of these
Pathogenesis and Immunology
Diphtheria toxin, produced by toxigenic strains of C. diphtheriae, is the primary virulence factor in clinical disease. The toxin is synthesized in precursor form; is released as a 535-amino-acid, single-chain protein; and has an LD50 of ~100 ng/kg of body weight. The toxin is produced in the pseudomembranous lesion and is taken up into the bloodstream, through which it is distributed to all organ systems.
Human growth is a measure of the physiological processes associated with birth weight,
genetics, and environment. Poor environmental factors, including inadequate health care and
nutrition can prevent the attainment of one’s full growth potential (Martorell, 1999; Pelletier,
1994; Monckeberg 1992). Health care providers that practice high quality prenatal and child
healthcare can directly influence the efficacy of the production of child health inasmuch as their
practices have an empirical basis.
Bacteroides vulgatus has been shown to be involved in the aggravation of colitis. Previously, we separated two potent virulence factors, capsular polysaccharide (CPS) and lipopolysaccharide (LPS), from a clinical isolate of B. vulgatus and characterized the structure of CPS. In this study, we elucidated the structures of O-antigen polysaccharide (OPS) and lipid A in the LPS. LPS was subjected to weak acid hydrolysis to produce the lipid A fraction and polysaccharide fraction.
One of the important determinants of virulence of Mycobacterium
tuberculosis is adaptation to adverse conditions encountered in the host
cells. The ability of Mycobacteriumto successfully adapt to stress condi-tions is brought about by the expression of specific regulons effected by a
repertoire of rfactors.
Your income after law school is an important factor in
determining what constitutes manageable payments on
your education loans. Although it may be difficult to predict
what kind of job you will get (or want) after law school, or
exactly what kind of salary you will receive, it is important
that you make some assessment of your goals for the
purpose of sound debt management. The money you
borrow will be paid out of your future earnings and may
have a significant effect on that lifestyle.
Bacillus cereusis an opportunistic pathogenic bacterium closely related to
Bacillus anthracis, the causative agent of anthrax in mammals. A significant
portion of theB. cereuschromosomal genes are common to B. anthracis,
including genes which in B. anthraciscode for putative virulence and sur-face proteins.
Horizontal gene transfer has been a major force for genome plasticity over
evolutionary history, and is largely responsible for fitness-enhancing traits,
including antibiotic resistance and virulence factors. In particular, for adap-tation of prokaryotes to extreme environments, lateral gene transfer seems
to have played a crucial role.