This sentiment was well expressed by Charcot in one of his many teaching sessions on amyotrophic lateral sclerosis
(ALS). It holds as true today as it did in 1865 and the search must continue but progress has been incredible in
recent years. There has been an exponential increase in the number of publications dealing with ALS and motor
neuron diseases in the last 50 years, as evidenced by listings in PubMed and related data bases.
The Editors extend their utmost thanks to the internationally renowned experts that have contributed to this
By WHO region of the world, use of improved domestic fuels (e.g. LPG, kerosene) in
rural areas vary from under 15 percent in Sub-Saharan Africa and South East Asia, to 33
percent in the Western Pacific developing region, and closer to 50 percent in Eastern
Mediterranean and Latin American countries. The main types of unimproved fuels used
in rural areas are firewood, dung and other agricultural residues, followed by charcoal
and coal/lignite (Rehfuess et al., 2006). Indoor air pollution from SFU is generalized
throughout the developing world.
Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium
tuberculosis.TB is a major disease burden globally. In 2006 it was estimated that there was 9.2
million incident cases, and among these 0.7 million cases were HIV-positive. The HIV
prevalence in TB patients is less than 1% in the Western Pacific but 22% in Africa, however, in
countries with the highest HIV prevalence; more than 75% of cases of TB are HIV-associated.