Specification by Example is an emerging practice for creating software based on realistic examples, bridging the communication gap between business stakeholders and the dev teams building the software. In this book, author Gojko Adzic distills interviews with successful teams worldwide, sharing how they specify, develop, and deliver software, without defects, in short iterative delivery cycles.
Propofol is very lipid soluble, has a large volume of distribution, and can be given for
prolonged periods of time without significant changes in its pharmacokinetic profile.
Because propofol has no active metabolites, the termination of its clinical effect is dependent
solely on redistribution to peripheral fat tissue stores. When the infusion is discontinued, the
fat tissue stores redistribute.
Ozone presents difficulties. It is an important issue which may grow in importance in the
future if, as anticipated, concentrations rise, but the only acceptable way of monitoring it
at remote locations, without a power supply, is diffusion tubes. These have been used in
the ICP Forests Level 2 programme, but do not give values for peak ozone incidents,
which are believed to cause visible ozone symptoms.
A detailed proteolysis study of internalized diphtheria toxin (DT) within
rat liver endosomes was undertaken to determine whether DT-resistant
species exhibit defects in toxin endocytosis, toxin activation by cellular
enzymes or toxin translocation to its cytosolic target.
Welcome to The Dumbest Moments in Business History. This volume is a collection of cautionary tales from which we all can learn valuable lessons about how not to conduct business...
A bad idea has to start somewhere. It's that old business maxim: You can's make a defective omelet without designing a really inefficient, expensive and dangerous way of breaking some eggs. Welcome to R& D.
OP Amps deliberately straddles that imaginary line between the technician and engineering worlds. Topics are carefully addressed on three levels: operational overview, numerical analysis, and design procedures. Troubleshooting techniques are presented that rely on the application of fundamental electronics principles. Systematic methods are shown that can be used to diagnose defects in many kinds of circuits that employ operational amplifiers.
One of the book's greatest strengths is the easy-to-read conversational
The coatings present a compact structure, without any visible delaminations or defects. The
morphology of the fracture of coatings is characterized by a dense structure, in some cases
there is a columnar structure (Figs. 1, 2, 3). The fracture surface of the steel samples was
examined and the deposited coatings show a sharp transition zone between the substrate
and the coating.
Neutrophil Abnormalities A defect in the neutrophil life cycle can lead to dysfunction and compromised host defenses. Inflammation is often depressed, and the clinical result is often recurrent with severe bacterial and fungal infections. Aphthous ulcers of mucous membranes (gray ulcers without pus) and gingivitis and periodontal disease suggest a phagocytic cell disorder. Patients with congenital phagocyte defects can have infections within the first few days of life. Skin, ear, upper and lower respiratory tract, and bone infections are common. Sepsis and meningitis are rare.
Severity is highly variable. Known modulating factors are those that ameliorate the burden of unpaired α-globin inclusions. Alleles associated with milder synthetic defects and co-inheritance of α-thalassemia trait reduce clinical severity by reducing accumulation of excess α globin. HbF persists to various degrees in β-thalassemias. γ-Globin gene chains can substitute for βchains, generating more hemoglobin and reducing the burden of α-globin inclusions. The terms β-thalassemia major and β-thalassemia intermedia are used to reflect the clinical heterogeneity.
Phrenology is a system of Mental Philosophy. It enquires into the quality and condition of the mind,
estimating the faculties, sentiments, and propensities of the individual, without being deceived by personal
esteem or the voice of partial praise; for as it too frequently occurs that minds of the highest order are more or
less under the influence of self love, or a desire for the admiration of others, so are they blinded to their own
weaknesses and in some measure rendered incapable of acknowledging their faults even to themselves.
We showed expression of the tryptophan hydroxylase gene
and of tryptophan hydroxylase protein immunoreactivity in
mouse skin and skin cells. Extracts from skin and melano-cyte samples acetylated serotonin toN-acetylserotonin and
tryptamine toN-acetyltryptamine. A different enzyme from
arylalkylamineN-acetyltransferase mediated this reaction,
as this gene was defective in the C57BL6 mouse, coding
predominantly for a protein without enzymatic activity.
Serotonin (but not tryptamine) acetylation varied according
to hair cycle phase and anatomic location....