Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus...
For half a billion women in developing
regions worldwide, anemia is a life-long burden,
one which affects most of their infants
and young children as well. Controlling anemia
in these vulnerable groups could significantly
reduce maternal and infant morbidity.
It would also enhance intellectual and work
capacity, thereby improving family, community
and national socioeconomic development.
In May 2002, the General Assembly of
the United Nations reemphasized that control
of nutritional anemia should be one of the
global Development Goals to be achieved in
the early years of this new millennium.
Bovine glutamate dehydrogenase is potently inhibited by zinc and the major
impact is on Vmaxsuggesting a V-type effect on catalysis or product release.
Zinc inhibition decreases as glutamate concentrations decrease suggesting a
role for subunit interactions.
In Arabidopsis thaliana, the BTB⁄POZ-MATH (BPM) proteins comprise a
small family of six members. They have been described previously to use
their broad complex, tram track, bric-a-brac⁄POX virus and zinc finger
(BTB⁄POZ) domain to assemble with CUL3a and CUL3b and potentially
to serve as substrate adaptors to cullin-based E3-ligases in plants.
As an essential element, selenium is present in enzymes from
several families, including glutathione peroxidases, and is
thought to exert anticarcinogenic properties. A remarkable
feature of selenium consists of its ability to oxidize thiols
under reducing conditions. Thus, one mode of action
recently suggested is the oxidation of thiol groups of metal-lothionein, thereby providing zinc for essential reactions.
We previously reported that GTS1 is involved in regulating ultradian oscillations of the glycolytic pathway induced by cyanide in cell suspensions as well as oscillations of energy metabolism in aerobic continuous cultures. Here, we screened a yeast cDNA library for proteins that bind to Gts1p using the yeast two-hybrid system and cloned multiple TDH cDNAs encoding the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
The Sp family is a family of transcription factors that bind to cis-elements in the promoter regions of various genes. Regulation of transcription by Sp proteins is based on interactions between a GC-rich binding site (GGGCGG) in DNA and C-terminal zinc ﬁnger motifs in the proteins. In this study, we characterized the GC-rich promoter of the gene for the DNA methyltransferase (Dnmt1) that is responsible for methylation of cytosine residues in mammals and plays a role in gene silencing.
In the course of trying to understand the pathogenesis of leishmaniasis in relation to extracellular matrix (ECM) elements, laminin, a major ECM protein, has been found to bind saturably and with high aﬃnity to a 67-kDa cell surface protein of Leishmania donovani. This interaction involves a single class of binding sites, which are ionic in nature, conformation-dependent and possibly involves sulfhydryls. Binding activity was signiﬁcantly enhanced by Zn2+, an eﬀect possibly mediated through Cys-rich zinc ﬁnger-like sequences on laminin....
Some limited understanding of self-renewal exists and, intriguingly, implicates gene products that are associated with the chromatin state, a high-order organization of chromosomal DNA that influences transcription. These include members of the polycomb family, a group of zinc finger–containing transcriptional regulators that interact with the chromatin structure, contributing to the accessibility of groups of genes for transcription.
The orphan receptors, Rev-erba and Rev-erbb, are members of the
nuclear receptor superfamily and specifically repress apolipoprotein CIII
(apoCIII) gene expression in rats and humans. Moreover, Rev-erbanull
mutant mice have elevated very low density lipoprotein triacylglycerol
and apoCIII levels.
Enhancer of rudimentary homolog (Drosophila) (ERH) is a small, highly
conserved, nuclear protein with a unique three-dimensional structure,
whose gene has been identified in animals, plants and protists, but not in