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A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping

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A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping

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Gene expression connectivity mapping has gained much popularity recently with a number of successful applications in biomedical research testifying its utility and promise. Previously methodological research in connectivity mapping mainly focused on two of the key components in the framework, namely, the reference gene expression profiles and the connectivity mapping algorithms.

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