Báo cáo khoa học: Atypical PKCf is involved in RhoA-dependent mitogenic signaling by the P2Y12 receptor in C6 cells

When nucleotide hydrolysis is prevented, agonists of the P2Y12 receptor enhance the proliferation of C6 glioma cells by RhoA-dependent, protein kinase C (PKC)-dependent activation of the extracellular signal-regulated kinase (ERK) pathway [Claes P, Grobben B, Van Kolen K, Roymans D & Slegers H (2001)Br J Pharmacol134, 402–408; Grobben B, Claes P, Van Kolen K, Roymans D, Fransen P, Sys SU & Slegers H (2001)J Neurochem 78, 1325–1338].