Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor
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Molecular mechanics calculations on conformers of Ac-HGly-NHMe, Ac-b 2 -HAla-NHMe and Ac-b 3 -HAla-NHMe indicate that low-energy conformations of the b-amino acids backbone, corresponding to gauche rotamers around the Ca–Cbbond, may overlap canonical backbone conformers observed for a-amino acids. Therefore, Sub-stance P (SP) was used as a model peptide to analyse the structural and biological consequences of the substitution of Phe7andPhe8by(R)-b 2 -HPheandofGly9byHGly (R)-b 2 -HAla or (S)-b 3 -HAla....
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