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Comparing allele specific expression and local expression quantitative trait loci and the influence of gene expression on complex trait variation in cattle

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The mutations changing the expression level of a gene, or expression quantitative trait loci (eQTL), can be identified by testing the association between genetic variants and gene expression in multiple individuals (eQTL mapping), or by comparing the expression of the alleles in a heterozygous individual (allele specific expression or ASE analysis). The aims of the study were to find and compare ASE and local eQTL in 4 bovine RNA-sequencing (RNA-Seq) datasets, validate them in an independent ASE study and investigate if they are associated with complex trait variation.

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Nội dung Text: Comparing allele specific expression and local expression quantitative trait loci and the influence of gene expression on complex trait variation in cattle

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