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Human Resources for Health: Professionalism in Medicine

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Human Resources for Health: Professionalism in Medicine

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The process likely begins with the development of defects in the supply of cholesterol and fats to neurons, progressing to extensive oxidative damage, mitochondrial defects, and a shift of metabolism towards utilizing sources other than glucose and minimizing mito- chondrial involvement. In the end stage, neurons can no longer transmit signals effectively, and apoptosis is the best option to avoid damaging neighboring cells. A crucial role is played by astrocytes, the glial cells that supply cholesterol and fats to neurons. A consequence of excess exposure to glucose and oxidizing agents may lead to an initial damage due to glycation and oxidation of ApoE in astrocytes. The subsequent cascade begins with defects...

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