Phản ứng có hại trên thần kinh trung ương và tâm thần liên quan đến EFV ở bệnh nhân điều trị phác đồ DF/3TC/EFV

JSSN 1859 • 1663<br /> <br /> 2(1034)<br /> JPM<br /> 2017<br /> <br /> <br /> <br /> <br /> TAP<br /> •<br /> CHI Y HOC<br /> •<br /> THtfC<br /> •<br /> HANH<br /> JOURNAL OF PRACTICAL MEDICINE<br /> KY Nl|M 87 NAM THANH LAP BANG C0N8 SAN VlfT NAM (3/2/1930 - 3/2/2017)<br /> <br /> <br /> <br /> <br /> Nam thtr sau hai So 2 (1034) 2017. Bp Y te xuat ban va phat hanh hang thang<br /> The 62st year No. 2 (1034) 2017. Ministry of health publishes and releases monthly<br /> TAP CHI MUC LUC<br /> S6<br /> Y HOC<br /> 1034<br /> .TRAN DlEP KHOA, => D a c diem va cac y l u t l lien quan r l i<br /> DO QUANG HUAN loan nhip nhl a benh nhan tang h u y l t<br /> <br /> THI/C HANH • NGUYEN THI X U Y E N<br /> ap<br /> T h y c trang va giai phap hieu qua<br /> BO Y T E XUAT BAN kham c h u a benh bang y hoc co t r u y l n<br /> JOURNAL OF PRACTICAL MEDICINE tinh Thai Binh d i n nam 2020<br /> PUBLISHED BY MINISTRY OF HEALTH • NGUYEN XUAN HUY, => Nghien c u u tac dung cua mot so<br /> TRAN VAN THANH loai khang sinh v d i vi k h u l n d u c n g sinh<br /> B o trudng B o Y te san a nCr cong nhan khu cong nghiep<br /> Tong Bien tap tinh Hai D u o n g nam 2016<br /> PGS. TS. N g u y l n Th'j Kim Tien • NGUYEN KHAC MINH, => Nghien c u u k i l n t h u c thai dp hanh<br /> Pho Tong Bien tap NGUYEN VAN SONG, vi v l s u e khoe sinh san va cac y l u t l<br /> TS. Nguyen Vinh Hung TRAN OlNH T R U N G lien quan a hoc sinh trung hoc pho<br /> thong tai thanh p h i D a N l n g<br /> T h u ky T o a s o a n •NGUYEN HUNG CU'&NG, => Ti le n h i l m va phan b l genotype<br /> Ths. Bui Nam Trung NGO QUANG DLCONG, cua Human papillomavirus tren benh<br /> B a n Bien tap: TRAN Q U A N G CANH, nhan ung t h u sinh due n u<br /> GS. TS. Le Ngoc Trpng HIROSHI ICHIMURA,<br /> GS. TS. Ngo Quy Chau PHAM VAN THLFC<br /> GS. TS. Ha Van Quyet • NGO Q U A N G DUONG. => K i l n thuc, t h y c hanh va mot s i y l u<br /> GS. TSKH. Nguyen Van Dip NGUYEN VAN KHAI t l l i l n quan d i n benh giun d u c n g ruot<br /> GS. TSKH. Ha Huy Khoi cua phu huynh hoc sinh co con hoc tai<br /> GS. TS. Tran O u t Thp 4 t r u d n g tieu hoc o Hai D u o n g<br /> GS. TS. N g u y l n Viet Tien • T A V A N TRAM, => Oac diem lam sang, can lam sang -<br /> GS. TS. N g u y l n Anh Tri PHAM T H E HIEN k i t qua dieu tri bao ton v o gan trong<br /> PGS. TS. Ngo Van Toan chan t h u o n g bung kin tai Benh vien Da<br /> PGS. TS. N g u y l n Qud'c Tuan khoa Trung tarn T i l n Giang<br /> PGS. TS. Phan Van Tudng •NGUYEN VAN DUNG, => Danh gia tinh trang thai t r u hoa chat<br /> PGS. TS. N g u y l n Thi Bich Lien TRjNH BAO NGOC, bao ve t h y c vat qua s u a m e va n u d e<br /> PGS. TS. Luang Ngoc Khue TRAN TH| THOA, tieu cua phu n u dang cho con bu d u d i<br /> PGS. TS. Tran Quy T u c n g PHAM DUY T l / O N G 12 thang t u l i tai mot s i quan thanh p h i<br /> PGS. TS. Pham Thuc Hanh Ha Npi nam 2013<br /> TS. Vu Van Du • L E DiNH PHAN, NGUYEN => Hieu qua can thiep mo hinh tram y<br /> TS. Nguyen Bao Ngoc TUAN HUNG, OAO VAN t l xa tai 3 huyen, thanh p h i tinh Hda<br /> Trinh bay: DUNG, TRAN VAN H I K I N G Binh, 2016<br /> •V0 TH| H6NG, => Nghien c u u tinh hinh kiem soat hen<br /> N g u y l n Thai, Hai Yen<br /> NGUYEN THANH H6l, p h i quan va mot s i y l u t l nguy c o lien<br /> Toa s o a n : 138A G i a n g V 6 - HN NGUYEN VAN DO AN quan theo gina 2015 tai Benh vien Dai<br /> OT: 04.38460728; 04.37368092 hoc Y Hai Phong<br /> Fax:04.38464098; •TRAN DIEP KHOA, D a c diem va cac y l u t l lien quan r l i<br /> E-mail: info@yhth.vn DO QUANG HUAN loan nhip t h l t d benh nhan tang h u y l t<br /> Banbientap@yhth.vn ap<br /> Website: www.yhth.vn • L E THI. HUONG, => Phan u n g cd hai tren than kinh trung<br /> V a n phong dai dien phia Nam VO THI THU THUY u o n g va tarn than lien quan d i n EFV d<br /> 109A P a s t e u r - Q u a ' n 1, TP. H C M benh nhan dilu tri phac dl<br /> DF/3TC/EFV<br /> * Giay phep s o : 108/GP-BVHTT • NGUYEN O U C MINH => Gdp phan nghien c u u nguyen nhan<br /> Cap ngay 29-3-2001 va c o c h l b i n h sinh cua benh viem<br /> ISSN 1859-1663 k h d p dang thap theo quan d i l m y hoc<br /> c l truyln<br /> * Giay phep sura doi, bo s u n g • NGO QUANG DUONG, => K i l n thuc va t h y c hanh nudi con<br /> thang ra 2 ky NGUYEN VAN KHAI bang sua m e cua cac ba me cd con<br /> so: 256/GP-SDBS-GPHOBC d u d i 2 t u l i tai mot xa huyen thanh<br /> ngay 7/6/2004 mien, tinh Hai D u o n g nam 2016<br /> •TA VAN TRAM, => Cac y l u t l lien quan den loang<br /> * In tai: Cong ty CP In Sao Viet<br /> PHAM T H E HlEN x u o n g d n g u d i cao t u l i cd benh p h l i<br /> * In xong va nop luu chieu 2/2017<br /> t i c nghen man tinh tai Benh vien Da<br /> Gia 50.000d khoa T i l n Giang<br /> <br /> Y H O C T H l T C H A N H (1034) - SO 2/2017 1<br />  MUC LUC (S6 1034)<br /> <br /> • L E DINH PHAN, => So sanh k i t qua trirdc - sau can thiep mo hinh tram y te xa tai 3 52<br /> NGUYEN TUAN HUNG, huyen, thanh pho tinh Hda Binh, 2016<br /> OAO VAN DUNG,<br /> TRAN VAN H U ^ N G<br /> •NGUYEN TH| THANH HUONG, => Khao sat thai do, k i l n thi>c doi v d i s y co y khoa khdng mong 56<br /> HOANG T R U N G KlEN, muon cua d i l u d i r d n g , hq sinh tai Benh vien Da khoa Trung i r c n g<br /> L U U THI ANH T U Y E T , Thai Nguyen nam 2016<br /> NGUYEN THU TRANG,<br /> NGO TH| T U Y E T<br /> •NGUYEN HUY ANH, => D a n h gia cua cac ba me co con d i r d i 5 t u l i khi sir dung tiem 59<br /> L E THj HOAN, chung dich vu tai tinh Nghe An nam 2016<br /> T R U O N G OINH B A C<br /> •NGUYEN THj NGA, => T i n h gia trj va dp tin cay cua mot so cdng cu thu nhan phan h l i t i r 62<br /> KIM BAO GIANG, giang vien va sinh vien<br /> NGUYEN THANH HA<br /> •PHAN Q U O C HOI => T h y c trang u l n g mryu, bia cua nam gidi dp tuoi t i r 15 - 60 tai xa 65<br /> Tay Thanh, Yen Thanh, Nghe A n nam 2015<br /> •OAO TH| DUNG, => M6 ta t h y c trang benh sau rang va viem l y i cua hoc sinh Trung 68<br /> NGUYEN ANH CHI, hoc pho thong Chu Van An quan Ba D i n h , thanh pho Ha Ndi<br /> NGUYEN QUANG TRUNG<br /> •TRAN TUAN ANH, => D a c diem benh nhi cd tang ap l y c ddng mach p h l i tai Benh vien 71<br /> L E THI KIM DUNG, Da khoa Trung i r c n g Thai Nguyen<br /> DO THAI SON,<br /> NGUYEN TH| HA,<br /> L Y THUY MINH,<br /> PHAM TRUNG KlEN,<br /> VU VAN DU<br /> •OINH NGOC SON, => D a n h gia k i t qua c h a m sdc benh nhan sau p h i u thuat benh ly 75<br /> NGUYEN L E BAO TIEN tmrp't dot song that lirng, that lumg cung tai Benh vien H d u nghi Niet<br /> Ode<br /> • L E THj H U O N G => Hieu qua can thiep n h a m cai thien mot so chi s i danh gia chat 77<br /> l i r g n g d i l u tri HIV/AIDS tai Benh vien Da khoa huyen T h u a n Chau,<br /> tinh S e n La<br /> •TRAN NGQC Q U E => T h y c trang va giai phap phat then nguon nhan l y c y hoc co 79<br /> t r u y l n tinh Quang Binh den nam 2020<br /> •NGUYEN HOANG LONG, => K i l n t h d c va t h y c hanh tiem an toan cua d i l u d i r d n g vien Benh 82<br /> OAO THU THUY vien Da lieu Trung i r a n g n a m 2012<br /> •TRAN TH| KIM LIEN => Oanh gia t h y c trang sau rang do bu binh d Ida tuoi m i m non 84<br /> •HOANG TRUNG KlEN, => K i l n thdc va hanh vi t y bao ve s d c khde khi s d dung t h u l c bao ve 87<br /> NGUYEN TH| THANH HUONG, t h y c vat cua ngirdi nong dan canh tac che tai Thai Nguyen nam 2016<br /> NGUYEN XUAN TUNG<br /> •TA VAN TRAM, => Nghien c d u cac yeu t l tien lireng t d vong b i n h p h l i tac nghen 90<br /> PHAM THE HlEN man tinh tai B i n h vien Da khoa Trung tarn Tien Giang<br /> •TRUONG VIET T R U O N G ,<br /> => T h y c trang s d c khoe va benh t h i r d n g gap d cdng nhan lao dpng 94<br /> NGUYEN TH| QUYNH HOA<br /> trong mdi tmrdng vi khi hau nong tai Cdng ty Gang thep Thai Nguyen<br /> •PHAM TUNG LAM,<br /> => Nghien c d u dieu kien lao ddng va mdi tmrdng anh h i r d n g d i n s d c 96<br /> BANG XUAN KET,<br /> khde va cot s i n g cua ngirdi lao ddng b l c xep tai cac b i n cang nganh<br /> NGUYEN D U C TAI<br /> Giao thong Van tai, d l xuat giai phap d y phdng<br /> •PHAM TH| T U Y E T NGA,<br /> HOANG TH| THU TRANG,<br /> PHAM THj HANH QUYEN => Oac d i l m ton t h i r c n g md c d n g viing c l rang 100<br /> •DO VAN DUNG,<br /> BANG TH| NGOC BICH<br /> => Cac yeu t l nguy c c trong benh cham tay cua nhan vien y t l 102<br /> <br /> 2<br /> Y H O C THlTC HANH (1034) - SO 2/2017<br /> •PHAM NHUHUNG, T h a m do dien sinh ly hoc tim tren benh nhan co dien tarn 66<br /> NGUYEN QUANG TUAN Brugada<br /> •VO THj LAN, => Benh dpng mach vanh tren n h d n g benh nhan co b#nh van tim<br /> DO QUANG HUAN d i r a c p h l u thuat van tim tai Vien Tim thanh pho Ho Chi Minh<br /> •MAI THj HlEN, => Hieu qua dieu trj Corticoid tren mot s6 benh nhan benh than Iga<br /> D 6 GIA TUYEN,<br /> DANG THI VIET HA<br /> •PHAN Q U 6 C HOI => Xac djnh y l u to lien quan d i n sir dung n r g u , bia cua nam gidi dp<br /> tuoi tir 16 - 60 tai xa Tay Thanh, Yen Thanh, Nghe An nam 2015<br /> •OAO TH| DUNG, => M l i lien quan giCra k i l n thdc, thai dp, hanh vi c h a m sdc rang mieng<br /> NGUYEN ANH CHI, vdi benh sau rang, viem lei ciia hoc sinh t r a d n g Trung hoc p h i thong<br /> NGUYEN QUANG TRUNG Chu Van An, quan Ba B i n h thanh p h i Ha Ndi<br /> • L E TH| THANH HUONG, => Sir tham gia cua giao vien tieu hoc trong cdng tac y te t r i r d n g hoc<br /> CHU VAN THANG tai quan Thanh Xuan, nam 2012<br /> VU DlEN, L E THj THANH XUAN<br /> •NGUYEN TH| HOAI, => Khao sat sir tuan thu d i l u trj d benh nhan suy than man giai doan<br /> DOAN TH| HUONG, c u l i tai Khoa Ndi Tieu hda - T i l t nieu Benh vien Da khoa Trung i r a n g<br /> L U U THj ANH T U Y E T Thai Nguyen<br /> •NGUYEN THAI HUNG => D a n h gia m d c dp h i l u cua can bp y t l v d i bp cdng cu do l i r d n g<br /> D U O N G MINH D U C mdi t r i r d n g lam viec ( C O A C H ) tai Quang Ninh<br /> • L E TH| HUONG, => Phan d n g cd hai tren than lien quan den T D F d benh nhan dieu trj<br /> VO TH| THU THUY phac dd TDF/3TC/EFV<br /> •NGUYEN D U C MINH => Vai trd va djnh h i r d n g phat trien p h i r a n g phap dieu trj giam dau<br /> ben ngoai d l i v d i benh ly x i r a n g k h d p b l n g t h u l c Y hoc c l t r u y l n<br /> •HOANG TH| P H U O N G => T i l p can c h i n doan benh do Mycobacteria khdng lao<br /> •NGUYEN VAN S O N D a n h gia nguy c c va ty le hien mac benh n h i l m doc hda chat bao<br /> ve thirc vat d n g i r d i lao ddng ndng nghiep 2012<br /> •DANG HUNG MINH => Nghien c d u dac d i l m lam sang va can lam sang d benh nhan<br /> tran khi mang p h l i d i r d i 30 t u l i tai Trung tarn Hd h i p Benh vien<br /> Bach Mai<br /> •PHAM THj THU THUY, => Danh gia m l i lien quan giira trieu c h d n g lam sang, hinh anh ndi<br /> DAU XUAN CANH, soi, md benh hoc, HP va PH djch vj cua benh ly da day - ta trang tren<br /> NGUYEN TH| B A C H T U Y E T benh nhan x a gan<br /> •TRAN VAN THANH, => Nghien c d u k i l n thCrc, thai dp, thirc hanh va mot s i y l u t l lien<br /> NGUYEN VAN LANH quan d i n phdng cum gia e l m trirdc va sau can thiep cua ngizdi dan<br /> tai cac hp cd nudi gia c a m huyen Vj Thuy, tinh Hau Giang nam 2014<br /> •TRAN THj MAI OANH, => K i l n thdc, thai dp ciia hoc sinh p h i thong v l HIV/AIDS tai tinh Hai<br /> NGUYEN TH| HUONG, Dirang<br /> PHAN L E THU HANG<br /> •DOAN TH| N G A => K h l o sat k i t qua thirc hien mot s i can thiep dieu d i r d n g tren benh 152<br /> O A O T l E N TH|NH, nhan sau m l ndi soi tang sinh lanh tinh t u y l n tien liet tai Khoa Ngoai<br /> LA VAN LUAN T i l t nieu, Benh vien Da khoa Trung i r a n g Thai Nguyen nam 2016<br /> •TRAN ANH VU, => Cac y l u t l anh h i r d n g d i n thirc hien hoat ddng the lire tren benh 156<br /> NGUYEN TH| S O N nhan tang h u y l t ap tai Benh vien Trung i r a n g Thai N g u y l n nam 2016<br /> •BINH QUANG HUY, => Tinh trang dinh d i r d n g t h l hien qua chi s i BMI va trang thai huyet 158<br /> TRjNH HOANG HA, ap cua sinh vien nam t h d n h l t Dai hoc Q u l c gia Ha Npi, nam hoc<br /> VU NGQC 2014-2015<br /> •BUI TH| VAN ANH, => T r i r d n g h g p co rut mi tren sau p h l u thuat cat be 161<br /> NGUYEN XUAN HIEP<br /> •BP NGOC SON, => Hieu qua ciia thir nghiem t h d tir nhien b l n g may t h d cd mode 163<br /> NGUYEN VAN CHI, "SBT" cho benh nhan d g t c l p C O P D<br /> NGUYEN DANG O U C<br /> •VU TUAN ANH, Thai dp x d tri v d i thai du thang t h i l u l i tai Benh vien Phu san Ha 165<br /> NGUYEN D U Y A N H Ndi<br /> •DANG HUNG MINH, => Nghien cCru dot b i l n E G F R va mot so yeu t l lien quan d benh<br /> TRAN VAN CITONG nhan ung thir p h l i the bieu mo t u y l n d i l u tri tai Trung tarn Ho h i p<br /> Benh vien Bach Mai<br /> .PHAM TH! THU THUY => Gia trj npi soi da day trong phat hien s d m ung thir da day<br /> OAU XUAN CANH<br /> NGUYEN THI B A C H T U Y E T<br /> •NGUYEN L E BAO TlEN, => Dac diem r l i loan c h d c nang ho h i p t n r d c m l cua benh nhan veo 171<br /> DINH NGOC SON, cot s i n g n g y c d i r g e phau thu|t chinh hinh tai Benh vien HOm nghj Viet<br /> NGUYEN DUY LUAT Dire<br /> •D6 THjOlEP, => Bao Igc dien tir va mot s i y l u t l lien quan tai T r i r d n g Trung hoc 173<br /> PHAM VIET C U O N G , p h i thong C h i r c n g My A - C h i r c n g My - Ha Npi<br /> L U O N G MAI ANH,<br /> TRAN QUANG D U C<br /> HA ANH D U C<br /> •TO THANH P H U O N G , => D i l u trj t r i m cam nang co loan t h i n b l n g kich thich tir xuyen so 177<br /> DANG HOANG ANH k i t h g p v d i t h u l c an t h i n kinh va c h l n g t r i m cam<br /> • L E TH| HUONG, => T u l n thu d i l u trj d b i n h nhan HIV/AIDS tre e m tai Benh vien Nhi 178<br /> OOAN THUY LINH Trung i r c n g<br /> •NGUYEN THAI HUNG => D a n h gia dp tin cay kiem tra lai bp cong cu do lirdng mdi trirdng 182<br /> D U O N G MINH D U C lam viec (COACH) tren can bo y t l tai Quang Ninh<br /> •NGUYEN D U C MINH => Mo hinh gay viem k h d p gut cai tien tren ddng vat t h g c nghiem 186<br /> •NGO QUANG DUONG, => T h g c trang suy dinh d i r d n g d tre d i r d i 5 t u l i tai huyen Thanh Mien 188<br /> NGUYEN VAN KHAI - Hai D i r c n g nam 2016<br /> •NGUYEN L E BAO TlEN, => Dac diem lam sang, can lam sang cua benh nhan xep than d l t 191<br /> DINH NGOC SON,<br /> s i n g nggc, t h l t lirng do loang x i r c n g tai Benh vien HCru nghj Viet Dire<br /> NGUYEN DUY LUAT<br /> •VU XUAN TUYEN, => Nghien ciru cac y l u t l thuan Igi lam x u l t hien com dau nira d l u 194<br /> NGUYEN ANH TUAN Migraine<br /> • NGUYEN VAN VAN. =>Tinh trang thieu mau d cac ba me va can nang cua tre s o sinh tai 198<br /> TRAN VAN THANH Benh vien huyen Tien Phirdc, tinh Quang Nam, nam 2012<br /> •NGUYEN XUAN THUC, =>Tinh trang quanh rang va nhu c l u d i l u trj d cac benh nhan dai thao 201<br /> VU O U C MINH d i r d n g typ 2 tai Benh vien Da khoa tinh Ninh Binh, nam 2014<br /> •DO VAN DUNG, =>Ti le hien mac thdi khoang 1 nam benh cham tay cua nhan vien y 205<br /> DANG THj NGOC BICH tl<br /> •NGUYEN VAN LANH,<br /> => K i l n thirc, thai dp, t h g c hanh phdng c h l n g tac hai n g h l nghiep cua 207<br /> TRAN VAN THANH cdng nhan tinh Tra Vinh nam 2013<br /> •NGUYEN VIET QUANG,<br /> = > T h g c trang sire khoe tarn t h i n cua hoc sinh T r i r d n g Trung hoc c c 211<br /> CHU VAN THANG,<br /> s d Quang Trung, thanh p h i Thai Nguyen, tinh Thai Nguyen<br /> NGUYEN THj QUYNH HOA<br /> •NGUYEN XUAN T H U C =>Ket qua c l djnh rang va xiromg I rang bj sang c h i n bang nep 214<br /> composite<br /> •DANG HUNG MINH, => Nghien ciru v l nguyen nhan va cac dac diem lam sang, c|n lam 216<br /> BUI T U O N G LAN sang cua tran djch da mang djch t i l t<br /> •PHAM THj THU THUY,<br /> => Mot s i nhan xet 65 t r i r d n g h g p u vu da d i r c c c h i n doan mo benh 220<br /> DAU XUAN CANH ,<br /> hoc<br /> N G U Y E N THj B A C H T U Y E T<br /> •TRAN TH! MAI OANH,<br /> = > K i l n thirc, thai dp, t h g c hanh ve Iga chpn gidi tinh khi sinh cua 221<br /> N G U Y E N THI H U O N G ,<br /> cac san phu tai Benh vien Da khoa Q u l c t l Hai Phong<br /> PHAN L E THU HANG<br /> •CHU TRAM ANH,<br /> => Nghien ciru dac diem lam sang, X quang va hinh thai I n g tuy cua 224<br /> PHAM THj THU HIEN<br /> rang ham Idn thir hai h a m d i r d i<br /> •NGUYEN MANH C U O N G ,<br /> =>Banh gia k i t qua sir dung fibrin giau tieu cau trong phau thuat n h l 226<br /> L E HOANG TUAN<br /> rang ham Idn t h d ba ham d i r d i<br /> •HOANG NGQC SON,<br /> NGO HUU HANH => T r i r d n g h e p dieu trj gay x i r c n g got di lech d y e e n l n chinh c l djnh 228<br /> bang dinh steinmann (nhan xet cai tien cua f.kermad)<br /> <br /> <br /> <br /> 4<br /> Y H O C THlTC HANH (1034) - SO 2/2017<br /> •PHAM TH| THU HlEN =>Banh gia dac diem lam sang, X quang nhom rang phia t r u c e co s u 232<br /> dung c h i t soi<br /> •DUONG TRONG TAN, = > K i l n t h u c va t h y c hanh ve tiem an toan cua sinh vien dieu d u o n g 235<br /> HOANG NGOC SON, T r u c n g Cao d i n g Y te Thai Nguyen tai Benh vien A Thai Nguyen<br /> NGUYEN THUY QUYNH nam 2016<br /> •NGUYEN O U C NHU, =>Banh gia cac yeu t l lien quan d i n giam dinh t i n t h u c n g c c the c 237<br /> TRAN ANH TUAN n h u n g t r u c n g hep c h i n t h u c n g m l t<br /> •OOAN TH! HUE = > K l t qua can thiep nang cao nang l y c ciia ba me vk cham sdc ve 239<br /> sinh, u Im d tre s o sinh non thang d i l u tri tai Trung tarn Nhi khoa,<br /> Benh vien Trung u c n g Thai Nguyen<br /> •TA VAN TRAM, =>Tinh hinh c h u a rang tai Benh vien Da khoa T i l n Giang 242<br /> PHAM THE HlEN<br /> • NGO THj D'?U MINH, => Nghien c u u r l i loan nhjp t h l t d benh n h l n suy tim man tinh t r u c e 248<br /> D 6 QUANG HUAN va sau d i l u tri bang t h u l c u c che beta<br /> •NGUYEN TH! H 6 N G VAN, =>Tinh trang khang insulin va t i n t h u o n g m l t d cac benh nhan r l i 252<br /> HOANG BUI HAl, loan glucose luc ddi cd tang h u y l t ap<br /> VIEN VAN DOAN<br /> .OINH NGQC SON, => K i t qua cham sdc benh nhan sau m l tao hinh t h i n d l t s i n g ngyc, 253<br /> NGUYEN L E BAO TIEN t h l t lung b l n g b o m cement sinh hoc tai Benh vien H u u nghj Viet D u e<br /> .PHAM TH! THU HlEN =>Danh gia k i t qua d i l u trj npi nha rang ham Idn t h u hai ham d u d i tai 255<br /> Benh vien Rang Ham Mat Trung u o n g Ha Npi<br /> .HOANG NGQC SON, = > T h y c hanh va mot s i yeu t l lien quan d i n t h y c hanh phdng benh 257<br /> NGUYEN TRONG TIN, n h i l m xa nghe nghiep cua n h l n vien x-quang tai cac c o s o y te tren<br /> NGUYEN THlilY QUYNH dja ban tinh Quang Ngai nam 2016<br /> •HOANG THj PHUONG, => Nghien c u u mot s i y l u t l lien quan d i n mat dp x u o n g d benh 260<br /> B A C H VAN HO ANH nhan nam m l c benh p h l i tac nghen man tinh tai Benh vien da khoa<br /> tinh Thai Binh<br /> •NGUYEN VAN SON, =>Tinh hinh n h i l m doc mangan n g h l nghiep cua cdng nhan Cdng 262<br /> DINH THUC NGA ty C l p h l n H o p kirn S i t - Gang Thep Thai Nguyen<br /> • L E THj THUY LINH, = > B a n h gia k i t qua d i l u trj ndi nha rang ham s u a 266<br /> L U O N G MINH HANG<br /> TRAN THj MY HANH,<br /> NGUYEN THj THU HlEN<br /> •DANG HUNG MINH => Nghien c u u dac d i l m lam sang, can lam sang cua viem p h l i d 270<br /> benh nhan ung t h u phoi<br /> •PHAM THj THU THUY, =>So sanh tac dung cua t h u l c ampelop va ampelop k i t h o p v d i 272<br /> DAU XUAN CANH, amoxycilline + metronidazole trong d i l u trj loet da day - ta trang<br /> NGUYEN THj B A C H T U Y E T<br /> •TRAN THj MAI OANH, =>Mdt s i y l u t l lien quan den viec l y a chpn gidi tinh khi sinh cua 274<br /> NGUYEN THj HUONG, cac ba me den sinh con tai Benh vien Da khoa Q u l c t l Hai Phdng<br /> PHAN L E THU HANG<br /> •PHAN THj T 6 NHU, =>Xac djnh can nguyen va tinh khang khang sinh cua vi k h u l n d 276<br /> NGUYEN THj H U O N G GIANG benh nhan n h i l m k h u l n huyet d u o c d i l u trj tai Benh vien Quan y<br /> 103 (2011-2015)<br /> •NGUYEN L E BAO TlEN, =>Dac diem lam sang va can lam sang cua benh nhan t r u o t d l t 279<br /> OINH NGOC S O N s i n g t h l t lung, t h l t l u n g ciing Benh vien H u u nghj Viet D u e<br /> •DANG HUNG MINH, =>Dac d i l m lam sang, can lam sang, nguyen nhan hoi c h u n g thuy 282<br /> BUI THj P H U O N G THAO g i u a tai Trung t i m Hd h i p Benh vien Bach Mai<br /> •NGUYEN D U C NHU, => Nghien c u u mot s i dac diem c h i n t h u o n g m l t qua giam djnh t i n 285<br /> TRAN ANH TUAN thuong co t h l<br /> •NGUYEN THI H U O N G GIANG, =>Cac c h i t u c che SGLT2-nhdm t h u l c m d i trong d i l u trj benh dai 287<br /> PHAN TH! T 6 NHU thao d u o n g<br /> •YHTH =>Thdng tin y hoc 290<br /> <br /> <br /> <br /> <br /> Y H O C TH1/C HANH (1034) - SO 2/2017 5<br /> nhip nhanh t h l t giua ngay va dem. Co s y t u o n g quan TAI L I E U THAM K H A O<br /> giua t u l i , thai gian THA, d u d n g kinh nh7 trai, chi s i 1. Dao Thu Giang (2011), "Nghien ciru biSn thien<br /> k h l i c a t h l t trai, EF v d i s i l u g n g NTT t h l t trong 24 nhip tim va rdi loan nhip tim d benh nhan tang huyit ap co<br /> gid. Nguy c a RLN t h l t day hoac p h d c tap d benh thieu mau cue bo co tim", Y hoc thirc hanh. 774(7), pp.<br /> n h l n THA > 60 t u l i , thai gian THA > 5 nam va cd benh 119-121.<br /> D M V l l n l o o t la OR = 3,71 ( 9 5 % C I : 1,54 - 8,92), OR = 2. Pham Thai Giang (2012), "Nghien ciru roi loan<br /> 6,53 ( 9 5 % C I : 2,59 - 16,51) va OR = 2,78 ( 9 5 % C I : 1,16 nhip tim o benh nhan tang huyet ap nguyen phat", Hoi<br /> - 6,65). Nguy c a RLN t h l t day hoac p h d c tap d benh nghj Tim mach toan qudc Idn thCr 13.<br /> nhan THA cd PBTTr va EF < 5 0 % l l n l o o t la OR = 3. Acharya T (2015), "Frequent atrial premature<br /> 2,48 ( 9 5 % C I : 1,18 - 5,20) va OR = 4,89 ( 9 5 % C I : 2,11 complex and their association with risk of atrial fibrillation",<br /> Am J Cardiol. 116, pp. 1852 - 1857.<br /> -11,09).<br /> 4. Barison A, Vergaro G (2011), "Markers of<br /> Arrhythmogenic Risk in Hypertensive Subjects", Curr<br /> Pharm Des. 17, pp. 3062 - 3073.<br /> <br /> <br /> PHAN LFNG CO HAI TREN THAN KINH TRUNG LTONG VA TAM THAN<br /> LIEN QUAN DEN EFV & BENH NHAN DIEU TRj PHAC DO DF/3TC/EFV<br /> L E TH| H U O N G , V O THj T H U T H U Y<br /> Cue Phong, chong HIV/AIDS, Twang Dai hoc Dope Ha Npi<br /> <br /> <br /> TOM T A T related factors about ADR of EFV on CNS & Metal in<br /> Muc tieu: Mo ta dac diim phan irng cd hai (ADR) patients with TDF/3TC/EFV regiment. Methods: This is<br /> tren he than kinh trung irong (TKTW) va tarn thin lien a prospective cohort study through targeted<br /> quan din EFV d benh nhan dieu tri phac dd spontaneous reporting on 838 new patients from May<br /> TDF/3TC/EFV va xac dinh mot sd yiu td lien quan din 03/2015 in An Giang, Dien bien, Lao Cai, Thai Nguyen,<br /> ADR. Phirong phap: Nghien cu>u thuin tap tiin ciru Ha Noi, Nghe An, Ho Chi Minh City. Results: There is<br /> thong qua bao cao tir nguyen cd chu dich tren 841 a significant percentage (38.7%) of patients<br /> benh nhan mdi dieu tri tir thang 03/2015. Kit qua: Cd experiencing the ADR on CNS and Metal related to<br /> mot ty le dang ke (38,7%) benh nhan gap ADR tren he EFV in patients with TDF/3TC/EFV. Maily is anifested<br /> TKTW & tarn thin lien quan din EFV khi diiu tri phac dizziness (29.5%), headache and fatigue (19.4%),<br /> dd TDF/3TC/EFV. Biiu hien chu yiu la chdng mat feeling hot flushes (10.7%), nausea (9.8%>). The heavy<br /> (29,5%), tiip din la dau diu va met mdi (19,4%), cam ADR intend to commit suicide and depression have<br /> giac ndng bimg (10,7%), budn ndn (9,8%). Cac ADR also been recorded at the rate of 0.1%. Some factors<br /> nang nhw cd y dinh tir tir va trim cam cung da dirge related were: age, hemoglobin levels and clinical<br /> ghi nhan vdi ty le 0,1%. Mot sd yiu to lien quan la: stage. Conclusion: There is a significant percentage<br /> tudi, ndng do hemoglobin va giai doan lam sang. Kit (38.7%) of patients experiencing CNS & Metal ADR<br /> luan: Cd mot ty le dang ki (38,7%) benh nhan gap related EFV in patients treated with TDF/3TC/EFV but<br /> ADR tren he TKTW & tarn thin liin quan din EFV d mainly mild so the vast majority of patients still<br /> benh nhan diiu trj phac dd TDF/3TC/EFV. Tuy nhien, maintenance treatment. Since, we need a thorough<br /> chu yiu ADR d mire do nhe nen dai da sd benh nhan consultation for patients before and during treatment,<br /> vin duy tri phac dd diiu tri. Vi vay, nhan vien y ti cin especially during the first period to avoid treatment<br /> tw vin ky lirdng cho benh nhan trirdc va trong qua dropping out.<br /> trinh diiu trj, dac biet la trong thdi gian diu diing thuoc Keywords: ADR, CNS and metal,EFV<br /> di tranh viec benh nhan tiry bo thubc. O A T VAN O E<br /> Tie khoa: phan irng cd hai, thin kinh trung uvng va T h u l c A R V da d e m lai nhieu loi fch cho benh nhan<br /> tarn thin, EFV HIV/AIDS. Tuy nhien, trong qua trinh s o dung van<br /> SUMMARY t h u d n g xay ra cac v i n d i lien quan den an t o l n t h u l c ,<br /> EFV- RELATED ADVERSE DRUG REACTION ON CNS dac biet la cac bien c l b i t loi nghiem trong tac dgng<br /> AND MENTALOF PATIENT TREATED WITH TDF/3TC/EFV d i n tuan thu dieu trj [1]. Trong khi phac d l chu yeu dang<br /> Objective: Describing characteristics and identifying d i l u trj la TDF/3TC/EFV thi phan ung cd hai tren TKTW<br /> & tarn than cua EFV d u o c khuyen cao giam sat [2].<br /> Chiu trach nhiem: Le Thj Hirdng Tai Viet Nam, s i l u o n g bao cao v l phan d n g cd<br /> Dja chi: Cue F>hdng, ching HIV/AIDS hai cua t h u l c con r l t han c h l va khdng phan anh dung<br /> Email: lehuongvaac@gmail.com t h y c t l d i l u trj [3]. Vi vay, chung tdi t i l n hanh nghien<br /> Ngay nhan:<br /> c d u : 'Phan d n g cd hai tren than kinh trung u o n g va<br /> Ngay phan bien:<br /> tarn t h i n lien quan t d i EFV tren benh nhan dieu trj<br /> Ngay duyet bai:<br /> phac do TDF/3TC/EFV".<br /> Ngay xuit ban:<br /> <br /> <br /> 40<br /> Y H O C T H l T C H A N H (1034) - SO 2/2017<br /> <br /> i<br />  D 6 l T U Q N G VA P H U O N G PHAP NGHIEN C U U 2.1. Tan suit gap ADR tren TKTW va tarn than<br /> 1. Doi tircmg nghien ciru Bang 1. Cac bieu hien ADR tren T K T W va tarn t h i n<br /> Gom 841 benh nhan m d i dieu tri phac do<br /> TDF/3TC/EFV tai 5 tinh/thanh pho trong t h a i gian tir STT Bidn c6 co hai n = 838 %<br /> 16/03/2015 d i n 15/07/2016. Sau khi loai trir 3 benh 1 Chong mat 248<br /> nhan khdng quay lai tai kham thi con lai 838 benh 2 Dau dau 163 19 5<br /> 3 Met moi 163 19,5<br /> nhan d u p e tham gia nghien c d u .<br /> 4 Cam giac nong bung 90 1n 7<br /> 2. P h u a n g phap nghien c u i i 5 Buon non 82 9,3<br /> Nghien c d u thuan tap tien c d u thong qua bao cao 6 Mo nhieu, g i l c mo rd rang 45 5.4<br /> to nguyen cd chu dich. 7 M l t ngu 43 5,1<br /> Sd lieu thu thap d u p e lam sach, nhap b l n g Epidata 8 Ac mong 39 4,7<br /> 3.1, quan ly va phan tich b l n g S P S S 16.0. Sir dung ky 9 Lo ling 31 3,7<br /> 10 Di cam: dau , ngira , rat, kiln bo 6 0.7<br /> thuat phan tich thong ke md ta, kiem dinh X2 va md<br /> 11 Giam/mat tap trung 5 0,6<br /> hinh hoi quy logistic de t i m moi lien quan. 12 Co y dinh t y tip 1 0,1<br /> K E T Q U A VA BAN LUAN 13 T r i m cam 1 0,1<br /> 1. T h o n g tin c h u n g ve doi t u p n g nghien c u u 14 Bieu hien khac 6 0,7<br /> Dac diem cua m i u benh nhan trong nghien c d u<br /> khdng cd s o khac biet nhieu v d i dac diem benh nhan Bang 1 cho t h l y : Bieu hien ADR d u p e ghi nhan<br /> n h i i m HIV/AIDS tai Viet Nam. Trong 838 benh nhan n h i l u n h l t la chdng mat (29,5%), t i l p d i n la dau d i u<br /> dirge chgn thi nam gidi c h i l m ty le nhieu h o n vdi va met mdi (19,4%), cam giac ndng b u n g (10,7%). Mot<br /> 66,9%. P h l n ddng benh nhan dang d dd tuoi lao ddng, sd ADR nang n h u cd y dinh t y tip va t r i m cam cung<br /> trung binh la 33,9 ± 7,5 tuoi. Benh n h l n lay n h i i m HIV d u p e ghi n h l n v d i ty I I 0 , 1 % . K i t qua nay t u o n g ddng<br /> chu yeu qua con d i r d n g tinh due ( 5 8 , 1 % ) va nghien vdi thong tin d u p e ghi nhan trong y van cung n h u<br /> chich ma tuy (37,2%). Tai thdi diem bat dau theo doi, nhung nghien ciru tong quan [4],<br /> sd benh n h l n dang d giai doan lam sang 1 c h i l m ty le 2.2. Xac suit xuat hien ADR tren TKTW va tarn<br /> cao n h l t 6 2 , 4 % . than<br /> Bang 2. T h d i gian t u khi dung thudc d i n khi x u l t<br /> 2. O a c diem A D R tren T K T W va tarn than lien<br /> hien ADR tren T K T W va tarn than<br /> quan den E F V<br /> Cd 324 benh nhan (chiem 3 8 , 7 % ) tren tong sd 838 Thai gian n %_<br /> benh nhan d i r g e nghien ciru gap b i l n cd tren T K T W Dudi 1 t u l n 136 42,0<br /> va tarn t h i n . Ty le nay t h l p h o n k i t qua trong nghien 1 tuan - 3 thang 0 0,0<br /> do t h i l t ke nghien ciru khac nhau (co mau, tieu c h u l n Thong so thong ke (ngay)<br /> Gia tri trung vi: 7 Tir phan vi 25%: 1<br /> lya chpn benh nhan, tieu c h u l n danh gia), c h i t lirgng<br /> Tu phan vi 75%: 10<br /> cua cac p h i r o n g phap danh gia, each sir dung cac<br /> thuat n g u ("doc tinh tren t h i n kinh trung i r a n g " , "tarn<br /> Bang 2 cho t h l y : T h d i gian trung binh gap ADR<br /> t h i n " , "tarn than, than kinh trung i r a n g " ) . Tuy nhien,<br /> tren T K T W va tarn t h i n la 9,3 ± 12,7 ngay va t h u d n g<br /> d i l u dang chu y d day la ty le 3 8 , 7 % trong nghien ciru<br /> x u l t hien s d m trong vdng 1 t u l n (42,0%) den 1 thang<br /> cua chung tdi v i n cao h o n nhieu khi so sanh v d i (52,5%), Theo Kenedi va cdng s y (2011), cac ADR<br /> nghien ciru g i n day tai Viet Nam cua N g u y i n P h i r o n g t h u d n g b i t d i u x u l t hien trong 1-3 ngay d i u d i l u tri,<br /> Thuy nam 2013 (12,3%). Nghien ciru cua N g u y i n dat cao n h l t sau 1-2 t u l n dieu trj [8]. K i t qua nay cho<br /> Phirong Thiiy la nghien ciru t i l n ciru theo p h i r o n g t h l y , c l n phai chu trong theo ddi ADR tren T K T W va<br /> phap giam sat b i l n cd thuan tap (CEM) theo ddi t i t ca tarn t h i n ngay sau khi d i l u trj de cd bien phap can<br /> cac loai phac dd sir dung tren benh n h i n , t i t ca cac thiep xir tri kjp thdi, h o p ly va hieu qua.<br /> benh nhan d m l u theo ddi dinh ky hang thang d i u 2.3. Mire do nang cua ADR tren TKTW va tarn<br /> d u p e giri bao cao v l Trung tarn DI&ADR Qudc gia. than va each xCr tri<br /> Nhir v i y , s y khac biet Idn nay cd the la do cac phan Bang 3. Mire dp nang cua ADR tren T K T W va tarn<br /> irng tren TKTW & tarn t h i n chu y l u d mire dp nhe, than<br /> thoang qua, d l bi n h l m l l n vdi cac trieu chirng lam<br /> sang cua benh, dac biet tren benh nhan nghien chich Phan loai n %<br /> ma tuy nen cd the bj bd qua, khdng d u p e ghi nhan vao Muc do 1 (nhe) 249 76,9<br /> hd s o benh an. Trong khi dd, ddi vdi phirong phap TSR Muc do 2 (trung binh) 72 22,2<br /> d nghien ciru cua chiing tdi, phan Idn cac bieu hien ddc Muc do 3 (nang) 3 0,9<br /> Muc do 4 (tu vong, de doa tinh mang) 0 0,0<br /> tinh nhe, thoang qua tren t h i n kinh trung i r a n g va tarn<br /> than d i u d u p e bac s i chu y theo ddi, ghi n h l n .<br /> <br /> <br /> <br /> <br /> Y HOC THlTC HANH (1034) - SO 2/2017 41<br />  Bang 4 Cac bien phap x u tri tren benh nhan co c o x u l t hien ADR tang them 2 % . N l u ndng dp<br /> ADR tren TKTW va tarn t h i n hemoglobin ban d i u tang them 1 d o n vj thi nguy c o<br /> x u l t hien ADR tang them 0,8%. Nguy c o m l c b i l n c l<br /> Bien phap xir tri n = 324 % tren T K T W va tarn t h i n d nhdm benh nhan d giai doan<br /> Tu van, tiep tuc ulng thuoc 314 96,9 lam sang 1 cao h o n g l p 1,46 l l n so vdi benh nhan d<br /> Dung them thulc xi> tri 4 1,2 giai doan lam sang 4.<br /> Giam lieu 0 0,0 Bang 6. K i t qua phan tich da b i l n cac y l u t l anh<br /> Ngimg thuoc 1 0,3 h u d n g tdi t i n s u i t x u l t hien ADR<br /> Doi phac do 4 1,2<br /> Chuyen tuyln 1 0_3_<br /> Yeu to HR Khoang tin P<br /> cay 9 5 % Cl<br /> Bang 3 va 4 cho t h l y : P h l n Ian cac ADR tren Tuoi 1,023 1,008- 1,038 0,002<br /> T K T W va tarn t h i n xay ra d m d c dp nhe (76,9%) va Can nang 0,981 0,967-0,995 0,008<br /> m d c dp trung binh (22,2%). Chi cd 3 t r u d n g h p p b i l n Giai doan lam sang 0,075<br /> co cd hai xay ra d m d c dp nang (0,9%). Vi vay, p h l n Giai doan 1 1,577 1,088-2,286 0,016<br /> Idn cac benh nhan d u p e t u v i n va each u l n g thuoc Giai doan 2 1,671 FF1.062-2,627 0,026<br /> hpp ly c h i l m 9 6 , 9 % va sau do benh nhan v i n duy tri Giai doan 3 1,309 0,790-2,167 0,296<br /> phac d l d i l u tri. Cd 4 benh nhan ( 1 , 2 % ) dung them Hemoglobin 1,010 1,004- 1,016 0,001<br /> thudc khac x u tri va chi cd 1 t r u d n g h p p phai tarn<br /> n g u n g t h u l c do bi phat ban do 3 va sau dd s u dung lai Bang 6 cho t h l y : Cac y l u t l t u l i (HR = 1,023; 9 5 %<br /> t h u l c EFV thi phan u n g khdng x u l t hien lai. Cd 4 benh Cl: 1,008 - 1,038; p = 0,002), can nang (HR = 0,981;<br /> nhan phai d l i phac d l ( c h i l m 1,2% trong t i n g s i benh 9 5 % Cl: 0,967 - 0,995; p = 0,008), ndng dp<br /> nhan gap ADR) cd 2 t r u d n g h p p d m u c dp nang, 2 hemoglobin huyet thanh (HR = 1,010; 9 5 % Cl: 1,004 -<br /> t r u d n g h p p d m u c d | trung binh. Theo Ribaudo va 1,016; p = 0,001) va giai doan lam sang 1 (p = 0,016)<br /> cdng s u (2004), khoang 4 % benh nhan phai d l i phac va giai doan lam sang 2 (p = 0,026) cd lien quan d i n<br /> d l do ddc tinh tren t h i n kinh trung u a n g lien quan d i n s u x u l t hien ADR tren T K T W va tarn t h i n . N l u can<br /> EFV. Ty le benh nhan d l i phac d l d nghien c u u cua nang cua n g u d i benh t r u d c khi b i t d i u dieu trj tang<br /> chung tdi t h l p han, cd the do dac diem benh nhan them 1 d o n vj thl nguy c o gap ADR tren T K T W giam<br /> khac nhau, h a n n u a viec xac djnh m u c dp nghiem 1,9%. N g u p c lai, n l u t u l i benh nhan tang 1 d o n vj thi<br /> trpng cua cac b i l n c l tren he than kinh trung u a n g va nguy c a gap ADR tren T K T W va tarn t h i n tang 2 , 3 %<br /> tarn t h i n la mot v i n de khd d i n g n h l t d l i v d i cac bac va n l u gia trj hemoglobin ban d i u tang 1 d o n vj thi<br /> s i do quan niem/nhan thuc cua bac sy v i m u c dp nguy c o x u l t hien bien c l tren T K T W va tarn than tang<br /> nghiem trpng cua phan u n g cd hai khac nhau nen cd 1,1%. Benh nhan d giai doan lam sang 1 va 2 cd nguy<br /> q u y l t djnh khac nhau. Vi vay, ty le d l i phac do cd the c o gap ddc tinh tren T K T W va tarn t h i n cao h o n so<br /> dao ddng g i u a cac nghien c u u . vdi benh nhan d giai doan lam sang 4.<br /> 3. C a c y e u t l lien quan den A D R tren T K T W v a KET LUAN<br /> tarn than c u a E F V Tuy co mot ty le khdng nhd benh nhan bao cao cd<br /> Bang 5. Phan tich d o n bien cac yeu t l anh h u d n g gap tac dung phu ciia EFV tren T K T W va t i m t h i n<br /> tdi t i n s u i t x u l t hien A D R nhung p h l n Idn x u l t hien s d m va d m u c dp nhe nen<br /> da s i benh nhan v i n t i l p tuc dieu trj ma khdng c l n<br /> Yeu to HR Khoang tin cay P den can thiep y te hay chuyen phac do. Ket qua nay<br /> 9 5 % Cl chi ra r i n g nhan vien y te can t u v i n ky l u d n g cho<br /> Tuoi (nam) 1,020 1,006- 1,034 0,005 benh n h l n t r u d c va trong qua trinh d i l u trj, dac biet la<br /> Gidi (nam/nu) 1,043 0,930- 1,170 0,470 trong thdi gian d i u dung t h u l c de tranh viec benh<br /> Can nang 0,992 0,980 - 1,005 0,215 nhan t y y bo t h u l c .<br /> Giai doan lam sang 0,135 T A i L I E U THAM K H A O<br /> Giai doan 1 1,460 1,022- 2,089 0,038 1. World Health Organization (2007),<br /> Giai doan 2 1,451 0,936 - 2,255 0,096<br /> Pharmacovigilance for antiretrovirals in resource-poor<br /> Giai doan 3 1,136 0,698 - 1,850 0,609<br /> countries.<br /> CD4 1,000 1,000- 1,001 0,269<br /> 0,004 2. World Health Organization (2013), Surveillance of<br /> Hemoglobin 1,008 1,003- 1,013<br /> ALT 0,999 0,996 - 1,002 0,411 antiretroviral toxicity: HIV/AIDS programme: Surveillance<br /> eGFR baseline 0,997 0,993 - 1,002 0,215 of antiretroviral treatment programmes.<br /> [Cre) baseline 1,000 0,994 - 1,005 0,928 3. Trung tarn Di&ADR Quoc gia (2013), T i n g k i t<br /> cdng tac bao cao phan ung co hai ciia thuoc (ADR) nam<br /> Bang 5 cho t h l y : K i t qua phan tich d o n bien da 2013, truy cap ngay 17 thang 11 nam 2016.<br /> phat hien 3 yeu t l anh h u d n g t d i tan s u i t x u l t hien 4. Ruiz N. M., B e s s e n L. J . , Manion D. J . , et al.,<br /> ADR tren T K T W va tarn t h i n d benh nhan la t u l i (p = "Potential adverse experiences associated with efavirenz<br /> 0,005), giai doan lam sang 1 (p = 0,038) va gia trj (EFV, sustiva™) in adults", Conf Retroviruses<br /> hemoglobin h u y l t thanh ban d i u (p = 0,004). N l u t u l i Opportunistic Infect 1999. Chicago, IL, February 1999<br /> benh nhan khi bat dau d i l u trj tang 1 d o n vj thi nguy [Abstract 655].<br /> <br /> <br /> <br /> <br /> Y H O C THlTC HANH (1034) - SO 2/2017<br /> <br /> L<br />