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Study on factors influencing synthesis of ethyl 3-aminocrotonate

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β-amino crotonate are compounds of interest since they find use as intermediates for the synthesis of Ca channel blockers such as Nisoladipine, Benidipine, Nicardipine and Felodipine. The method is characterized by allowing reaction between ethyl acetoacetate and ammonium acetate in methanol solution at a room temperature, for 20 hours and molar ratio ethyl acetoacetate with ammonium acetate is 1:3.

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