Synthesis and characterization of new (E)-N’-(substituted benzylidene)-2-(3-(2- methyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetohydrazides
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A small library of new azomethine derivatives of 3-aryl-2-thioxo-2,3-dihydroquinazolin-4(1 H) -ones was synthesized. The key intermediates 2-thioxo-quinazolinones (3a–e), obtained in 2 steps from the corresponding anilines, were treated with methyl chloroacetate to afford S-substituted esters (4a,d), which were then converted into corresponding acetohydrazides (5a,d). Further, acetohydrazide (5d) was converted to the azomethines derivatives (6a–k) by reacting with a number of suitably substituted benzaldehydes.
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