Analysis and repair

The objectives of the present study are: Justifying the possibility of using laser cladding technology as a repair method for refurbishment of worn railway axles without jeopardizing their fatigue properties; Analysis of crack initiation and propagation in laser clad samples.

130p runthenight07 01-03-2023 6 3   Download

Chromatin is a highly dynamic structure that plays an essential role in regulating all nuclear processes that utilize the DNA template including DNA repair, replication, transcription and recombination. Thus, the mechanisms by which chromatin structures are assembled and modified are questions of broad interest. This minireview will focus on two groups of proteins: (a) histone chaperones and (b) ATPdependent chromatin remodeling machines, that co-operate to assemble DNA and histone proteins into chromatin....

7p research12 01-06-2013 32 4   Download

The RuvABC resolvasome ofEscherichia colicatalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. This process involves two key steps: branch migration, catalysed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvAprotein, and resolution, which is catalysed by the RuvC endonuclease.

10p tumor12 22-04-2013 33 2   Download

The dermal glands of frogs produce antimicrobial peptides that protect the skin against noxious microorganisms and assist in wound repair. The sequences of these peptides are very dissimilar, both within and between species, so that the 5000 living anuran frogs may produce
100 000 different antimicrobial peptides.

14p fptmusic 16-04-2013 42 2   Download

We have previously reported that sulfoquinovosylmonoacylglycerol (SQMG) is a potent inhibitor of mammalian DNA polymerases. DNA polymeraseb(pol b) is one of the most important enzymes protecting the cell against DNA damage by base excision repair. In this study, we charac-terized the inhibitory action of SQMG against rat pol b. SQMG competed with both the substrate and the template-primer for binding to polb.

13p fptmusic 11-04-2013 40 1   Download

Replication protein A (RPA), a heterotrimeric protein composed of 70, 32 and 14-kDa subunits, has been shown to be essential for DNA replication, repair, recombination, and transcription. Previously, we found that, in two seed plants, rice and Arabidopsis, there are two different types of RPA70-kDa subunit. Substantial biochemical and genetic characterization of these two subunits, termed OsRPA70aand OsRPA70bor AtRPA70a and AtRPA70b, respectively, is described in this report.

12p fptmusic 11-04-2013 42 3   Download

Reversible tyrosine phosphorylation, catalyzed by receptor tyrosine kinases and receptor tyrosine phosphatases, plays an essential part in cell signaling during axonal development. Receptor protein tyrosine phosphatase-rhas been implicated in the growth, guidance and repair of retinal axons.

14p inspiron33 23-03-2013 36 4   Download

Spontaneous protein deamidation of labile Asn residues, generatingl-iso-aspartates andd-aspartates, is associated with cell aging and is enhanced by an oxidative microenvironment; to minimize the damage, the isoaspar-tate residues can be ‘repaired’ by a specific l-isoaspartate (d-aspartate) protein O-methyltransferase (PIMT).

15p media19 04-03-2013 63 1   Download

Neuroinflammatory mediators play a crucial role in the pathophysiology of brain ischemia, exerting either deleterious effects on the progression of tis-sue damage or beneficial roles during recovery and repair. Within hours after the ischemic insult, increased levels of cytokines and chemokines enhance the expression of adhesion molecules on cerebral endothelial cells,

14p vinaphone15 27-02-2013 55 3   Download

High molecular weight kininogen (HK) is an abundant plasma protein that plays a central role for the function of the kallikrein⁄kinin⁄kininogen sys-tem. Thus, cleavage of HK by kallikrein liberates bradykinin, which stimu-lates vascular repair and a two-chain protein, activated HK (HKa), which induces apoptosis in proliferating endothelial cells.

11p vinaphone15 25-02-2013 37 1   Download

Homologous recombination is a very important cellular process, as it pro-vides a major pathway for the repair of DNA double-strand breaks. This complex process is affected by many factors within cells. Here, we have studied the effect of monovalent cations (K + ,Na + , and NH4 + ) on the outcome of recombination events, as their presence affects the biochemical activities of the proteins involved in recombination as well as the structure of DNA.

11p viettel02 22-02-2013 39 3   Download

Protein kinases drive the cellular signal transduction networks that underlie the regulation of growth, survival and differentiation. To repair the deregu-lations of signaling cascades that are associated with numerous disease states, therapeutic strategies, based on controlling aberrant protein kinase activity, are emerging.

9p viettel02 20-02-2013 42 3   Download

The term ‘antimicrobial peptides’ refers to a large number of peptides first characterized on the basis of their antibiotic and antifungal activities. In addition to their role as endogenous antibiotics, antimicrobial peptides, also called host defense peptides, participate in multiple aspects of immunity (inflammation, wound repair, and regulation of the adaptive immune sys-tem) as well as in maintaining homeostasis.

12p viettel02 20-02-2013 46 3   Download

EVL is a member of the ENA⁄VASP family, which is involved in actin-remodeling processes. Previously, we reported that human EVL directly interacts with RAD51, which is an essential protein in the homologous recombinational repair of DNA double-strand breaks, and stimulates RAD51-mediated recombination reactionsin vitro.

8p viettel02 20-02-2013 37 3   Download

TIP49b (reptin) is an essential eukaryotic AAA+ ATPase involved in a variety of cellular processes, such as chromatin remodeling during double-strand break repair, transcriptional regulation, control of cell proliferation and small nucleolar RNA biogenesis.

10p mobifone23 21-01-2013 36 4   Download

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis...

13p thulanh9 07-10-2011 59 4   Download