Antiphospholipid antibody syndrome

Antineutrophil cytoplasmic antibody-associated vasculitis is dominated by inflammatory occlusion of small vessels, causing tissue ischemia in various organs. This disorder has rarely been associated with vasculopathy, such as antiphospholipid syndrome.

6p vigojek 02-02-2024 3 1   Download

The diferential diagnosis of abdominal pain in pregnant women is broad. Liver diseases as the origin of abdominal pain in pregnancy are rare, and severe forms occur in less than 0.1% of pregnancies. Some disorders, such as hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome and preeclampsia, are unique to pregnancy, while others, such as antiphospholipid antibody syndrome, may manifest in pregnancy but have consequences beyond the current pregnancy.

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Antiphospholipid syndrome (APS), defined by thrombotic events or obstetric complications in the presence of persistently high antiphospholipid antibodies, is characterized by a wide variety of clinical presentations and the effects of vascular occlusion can impact almost any organ system or tissue.

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Antiphospholipid antibody syndrome is characterized by venous and/or arterial thrombosis, and is found in patients with systemic lupus erythematosus. Its diagnosis requires the presence of both clinical and laboratory findings, such as positive anti-cardiolipin and anti-β2 glycoprotein I antibodies and lupus anticoagulant.

3p vinatri2711 29-02-2020 11 1   Download

Jaccoud’s arthropathy (JA) is a chronic, deforming, non-erosive arthropathy occurring in a subset of patients with systemic lupus erythematosus (SLE). In this research we aimed to evaluate clinical and immunological features in patients with SLE complicated by JA. Eighty seven consecutive SLE patients with a history of arthritis were included in the present study. These patients were subdivided according to ‘‘Jaccoud’s arthropathy index’’ as follows: non-deforming arthropathy, mild deforming and definite Jaccoud. Demographic data, disease activity and disability were recorded.

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(BQ) Part 1 of the document Harrison's rheumatology presents the following contents: The immune system in health and disease, disorders of immune mediated - Injury. Invite you to consult.

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Research objectives: To analyse of obstetric history and characteristics of anticardiolipin antibody and lupus anticoagulant in pregnant women with a history of RPL; assess the effectiveness of treatment pregnancy in women with a history of RPL by antiphospholipid syndrome by coordinating regimen low doses of aspirin and low molecular weight heparin.

12p change03 06-05-2016 47 1   Download

They were promised a miracle cure for the deadly diseases destroying their lives. It seemed too good to be true, but to the desperate and dying it was the only chance for survival. Now they're part of a bizarre secret experiment that reverses the aging process--an experiment gone out of control. To stop the madness, one woman must enter a shocking nightmare world, where scientists control your body--and your mind--and living makes you beg for death

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When searching the history of antiphospholipid antibodies one must meet cornerstone in Graham Hughes’s descriptions of antiphospholipid syndrome in his “Prosser-White Oration” to the British Society of Dermatology in 1983 (Hughes GRV; 1984). The main points of his lecture can be found in different publications (Hughes GRV; 1984, Hughes GRV; 1999, Khamastha MA; 2000) and they are still truthful although they have been expressed almost thirty years ago. He finished his own work (Hughes GRV 1980; Hughes GRV; 1983) and crowned also another authors’ important publication and observations.

241p thienbinh1311 13-12-2012 43 2   Download

The next important milestone emerged in 1990 when three independent working groups described the role of2-glycoprotein I as a target antigen in antiphospholipid antibodies’ action (Galli M, et al; 1990, Matsura E, et al; 1990, McNeil HP, et al; 1990). This discovery substantially changed point of view of many of the researchers and also clinical practisers in the topic and it led to research of 2-glycoprotein I structure, function and confirmation of significance of its antibodies presence during the next years....

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subject with the aim to help patients with antiphospholipid antibodies presence. Finally, this is why this book is presented to a wide range of readers. Forty seven contributors from nine countries bring together their knowledge and also their own experience from different fields of their professional work with the aim of providing a valuable resource for improving some of the points of view, decisions and treatment success in the antiphospholipid antibodies positive patients’ management.

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Immunity seems to be a fascinating system in the human body, whose role has never been understood in detail, despite the great progress in our knowledge about its role, regulation and its disorders. The same goes for autoimmunity diseases as well as antiphospholipid antibodies presence and antiphospholipid syndrome. Due to humoral nature of these autoantibodies they can impact every tissue and due to their heterogeneity and complex actions they can be connected with wide spectrum of clinical manifestations.

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Models of thrombosis risk. In each panel, the figure shows the thrombosis (black) potential of each risk factor present during an individual's life and the resultant thrombosis potential (red). (From FR Rosendaal: Venous thrombosis: A multicausal disease. Lancet 353:1167, 1999; with permission.) Several acquired risk factors are very strong, causing thrombosis in several percent of those afflicted, which implies a relative risk of ≥50.

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Figure 111-1 Models of thrombosis risk. In each panel, the figure shows the thrombosis (black) potential of each risk factor present during an individual's life and the resultant thrombosis potential (red). (From FR Rosendaal: Venous thrombosis: A multicausal disease. Lancet 353:1167, 1999; with permission.) Several acquired risk factors are very strong, causing thrombosis in several percent of those afflicted, which implies a relative risk of ≥50.

5p thanhongan 07-12-2010 71 3   Download