Arginine methylation

Xem 1-7 trên 7 kết quả Arginine methylation
  • The protein arginine methyltransferase (PRMT) family of enzymes cata-lyzes the transfer of methyl groups from S-adenosylmethionine to the gua-nidino nitrogen atom of peptidylarginine to form monomethylarginine or dimethylarginine. We created several less polar analogs of the specific PRMT inhibitor arginine methylation inhibitor-1, and one such compound was found to have improved PRMT inhibitory activity over the parent molecule.

    pdf13p mobifone23 21-01-2013 16 4   Download

  • RNomics is a newly emerging sub-discipline of genomics that categorically studies the structure, function and processes of non-coding ribo nucleic acids in a cell. MicroRNomics is a sub-field of RNomics that describes the biogenesis and mechanisms of tiny RNA regulators, and their involvement in the processes of development, differentiation, cell proliferation, cell death, chromosomal segregation and metabolism. The discovery of microRNAs in species ranging from Caenorhabditis elegans (C.

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  • Current evidence suggests that the beneficial effects of statins seem to be mediated not only by their lipid-lowering properties but also by improving vascular endothelial cell function. Chronic inhibition of endothelial nitric oxide synthesis by oral administration of Nw-nitro-L-arginine methyl ester (L-NAME) to rats induces early vascular inflammation and subsequent arteriosclerosis.

    pdf42p galaxyss3 19-03-2013 17 2   Download

  • The human 57 kDa Ki-1 antigen (Ki-1⁄57) is a cytoplasmic and nuclear protein, associated with Ser⁄Thr protein kinase activity, and phosphorylat-ed at the serine and threonine residues upon cellular activation. We have shown that Ki-1⁄57 interacts with chromo-helicase DNA-binding domain protein 3 and with the adaptor⁄signaling protein receptor of activated kinase 1 in the nucleus.

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  • Previous structural andmutagenesis studies indicate that the invariant a-amino and a-carboxyl groups of glutamate receptor agonists are engaged in polar interactions with oppositely charged, conserved arginine and glutamate resi-dues in the ligand-binding domain ofa-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor.To examine the role of these residues (R507 and E727 in the GluR-D subunit) in the discrimination between agonists and anta-gonists, we analyzed the ligand-binding properties of homomeric GluR-D and its soluble ligand-binding domain withmutations at thesepositions....

    pdf10p tumor12 22-04-2013 16 2   Download

  • The cytoplasmic and nuclear protein Ki-1⁄57 was first identified in malig-nant cells from Hodgkin’s lymphoma. Despite studies showing its phos-phorylation, arginine methylation, and interaction with several regulatory proteins, the functional role of Ki-1⁄57 in human cells remains to be determined.

    pdf14p vinaphone15 25-02-2013 22 1   Download

  • Histones are modified post-translationally, e.g. by methylation of lysine and arginine residues, and by phosphorylation of serine residues. These modifications regulate processes such as gene expression, DNA repair, and mitosis and meiosis. Recently, evidence has been provided that histones are also modified by covalent binding of the vitamin biotin.

    pdf11p fptmusic 11-04-2013 15 1   Download


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