Biochemical institute

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  • For the last nineteen years, I have had the great pleasure and privilege of teaching and learning about healing at the Rice Diet Program in Durham, North Carolina. Participants here, fondly nicknamed Ricers, have the opportunity to experience the fastest, safest, and most effective way to lose weight and improve every other modifi able risk factor of heart disease and, in fact, most diseases.

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  • Protein phosphorylation is a key mechanism for intracellular signal transduction in both prokaryotic and eukaryotic cells. Vertebrate proteins are prevalently phosphorylated on side chains that contain a hydroxyl group, such as serine, threonine and tyrosine residues. In the past decade, however, an increasing number of examples of histidine phosphorylation has been described.

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  • Institute for Organic Chemistry, University of Karlsruhe, Germany; 2Institute for Organic Chemistry, Budapest University of Technology and Economics, Hungary Elucidation of the 3D structure of histidine ammonia-lyase (HAL, EC from Pseudomonas putida by X-ray crystallography revealed that the electrophilic prosthetic group at the active site is 3,5-dihydro-5-methylidene-4H-i´ midazol-4-one (MIO) [Schwede, T.F., Retey, J., Schulz, G.E. (1999) Biochemistry, 38, 5355 –5361].

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  • Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Warsaw, Poland; Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary; 3Department of Inorganic Chemistry, and 4Research Group for Antibiotics, Department of Chemistry, University of Debrecen, Hungary; 5 International Institute of Molecular and Cell Biology, Warsaw, Poland This study characterizes the calcium-bound CR I – II domain (residues 1–100) of rat calretinin (CR).

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  • Laboratory for Lipoprotein Chemistry and 4Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research, Faculty of Medicine, Department of Biochemistry, Ghent University, Belgium; 2Laboratory of Biomolecular Dynamics, Katholieke Universiteit Leuven, Belgium; 3Ecole Normale Supe´rieure, Paris, France Penetratin is a 16-amino-acid peptide, derived from the homeodomain of antennapedia, a Drosophila transcription factor, which can be used as a vector for the intracellular delivery of peptides or oligonucleotides....

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  • Research in starch biosynthesis is likely to have a great impact on agriculture and industry in coming years. Although the original purpose of research into starch synthesis was not industrial application, it is an example of how science, while trying to answer fundamental questions, may lead to the manipulation of nature for beneficial purposes. Although the basic studies of starch synthesis were carried out in England during the 1940s, and led to the discovery of phosphorylase and Q-enzyme (branching enzyme), the basis of our modern ideas originated in Argentina from the work of Luis F.

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  • Meeting report Celebrating 40 years of biochemistry in Europe Errol C Friedberg* and Tomas Lindahl† Addresses: *Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA, †Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK. Correspondence: Errol C Friedberg. E-mail: friedberg.errol@pathology.swmed.

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