Biological activity of some compounds

The objectives of the thesis: Determine the chemical composition of three soft coral species S. nanolobata, S. conferta, S. leptoclados collected in the central sea of Vietnam; đetecting active substances with cytotoxic activity in soft corals studied, orienting their application for biomedical and pharmacological studies.

26p closefriend09 16-11-2021 15 4   Download

The research objectives of the thesis: Isolate and determine the chemical structure of compounds from C. candicans and C. macrophylla species collected in Vietnam. Assessment of toxic activity on some cancer cell lines: liver (Hep-G2), lung (Lu-1) and breast (MCF-7) of isolated clean compounds. Researching the chemical composition of C. candicans and C. macrophylla essential oils

29p extraenglish 24-05-2021 16 4   Download

Goals of the study: Synthesis of new organic compounds (target) containing imidazole-5-one heterocycle; thiazolidine-2,4-dione heterocycle or 1,3,4-oxadiazoline heterocycle with different substituents in experimental conditions of Vietnam. Study on the properties, structures and biological activities of these compounds to contribute to the studies of both theory and application of heterocyclic compounds.

27p prisonbreak123 21-05-2021 25 4   Download

Isolate and determine the chemical structure of compounds from C. candicans and C. macrophylla species collected in Vietnam; assessment of toxic activity on some cancer cell lines: liver (Hep-G2), lung (Lu-1) and breast (MCF-7) of isolated clean compounds, researching the chemical composition of C. candicans and C. macrophylla essential oils.

29p capheviahe26 25-01-2021 32 3   Download

Study on synthesis of hybrid compounds of some triterpenoids containing benzamide and hydroxamate groups in order to search for hybrid compounds with high biological activity, as a scientific basis for further research to create anti-cancer drugs, contribute to health care for the community.

38p larachdumlanat129 20-01-2021 37 4   Download

5-(4-Bromophenyloxymethyl)-1,3,4-oxadiazol-2-thiole (3a) and 5-(4 -methylphenyloxymethyl)-1,3,4-oxadiazol-2-thiole (3b) were synthesized starting from 4-bromophenol and 4-methylphenol (p-crezol), respectively. The 5-aryl- -oxymethyl-1,3,4-oxadiazole-2-thiole (3a, b) were treated with N-aryl-2-chloro- -acetamides to give six corresponding new N-aryl-[(5-aryloxymethyl-1,3,4- -oxadiazol-2-yl)sulfanyl]acetamides (4a1-3, 4b1-3).

7p tamynhan5 10-12-2020 7 2   Download

Obtaining of secondary metabolites from marine fungi isolated in the Central Vietnam and identifying some biological activities (antibiotimicrobial, cytotoxic, antioxidant, neuroprotective activities) of obtained individual compounds.

27p trinhthamhodang7 31-08-2020 38 2   Download

The thesis aims to study the chemical composition and survey the biological activity of two species: the lizard (B. laxiflora) and the cow breast (F. hirta). - Isolate and determine the chemical structure of two species of whole lizard (B. laxiflora) and the root of cow breast (F. hirta). Evaluation of some cytotoxic activity, anti-inflammatory activity, anti-proliferation activity on acute bone marrow cell line (OCI-AML) of extracting extracts and of some isolated compounds to orient for Next application studies.

27p xacxuoc4321 11-07-2019 46 4   Download

The objective of the thesis is to study to clarify the main chemical composition of two species C.novaeguinea and P. gracilis in the Northeast sea of ​​Vietnam. Evaluate the cytotoxic activity of some isolated compounds to search for bioactive compounds.

28p xacxuoc4321 11-07-2019 27 4   Download

The task of the thesis: Synthesis of new derivatives of indenoisoquinoline is based on changes in B ring groups by modifying branching atoms of nitrogen atom and binding of triazole-containing hybrid compounds. Synthesis of new derivatives of indenoisoquinoline based on the change of substituents in D ring with metoxyl groups or methylendioxy. Simultaneously change the substituents on B ring through the triazole bridge by click reaction.

28p xacxuoc4321 09-07-2019 24 3   Download

Recently, some of the furoquinoline alkaloids were found to have an interesting biological activity, for example, anti-cancer, antiplatelet aggregation and antifungal activities. The interesting biological activity made these compounds 1-13 attractive targets in organic chemistry. A novel generally applicable synthesis of furoquinolines is described. The condensation of 2- methoxy aniline and malonic acid in the presence of POCl3 gave 2,4-dichloro-8- methoxyquinoline. Then, treatment of this compound with sodium methoxide in methanol under reflux afforded 4,8-dimethoxyquinoline.

5p uocvong04 24-09-2015 68 5   Download

Twenty two N-arylidenehydrazides of [6-(2-hetarylvinyl)-3-oxopyridazine-2-yl] acetic acid have been synthesized starting from levulinic acid. Their structures have been confirmed by UV, IR, NMR and mass spectra. The spectral properties and the biological activity were investigated. Some of the tested compounds exhibit fungicidal and bactericidal activity at 25 µg/ml.

5p uocvong04 24-09-2015 42 2   Download

Derivaties of 1,2,4-triazole and 1,3,4-oxadiazole have a lot of biological activities such as antifungi, antibiotic, antivirus, antitumor, etc. Nineteen hetero-compounds have been synthesized. Their structures have been confirmed by elemental analysis and the spectra methods as UV, IR and NMR. In this study, we focus on the analysis the first defragments on the mass-spectra of some compounds which is derivaties of 1,3,4-oxadiazole and 1,2,4-triazole.

5p uocvong04 24-09-2015 38 3   Download

Template reactions play a very important role in the formation of many natural macro- heterocyclic compounds that have biological activities such as porphyrine, metalloenzyme etc. and become one type of the most important reactions in bioinorganic Chemistry and other relating fields.

5p uocvong03 24-09-2015 49 2   Download

Glucosinolates play important roles in plant defense against herbivores and microbes, as well as in human nutrition. Some glucosinolate-derived isothi-ocyanate and nitrile compounds have been clinically proven for their anti-carcinogenic activity. To better understand glucosinolate biosynthesis in Brassica rapa, we conducted a comparative genomics study with Arabidopsis thaliana and identified total 56 putative biosynthetic and regulator genes.

16p viettel02 22-02-2013 47 8   Download