Biological markers

Circular RNAs (circRNAs) are more stable than linear RNA molecules, which makes them promising diagnostic biomarkers for diseases. By circRNA-sequencing analysis, we previously found that circN4BP2L2 was significantly decreased in epithelial ovarian cancer (EOC) tissues, and was predictive of disease progression.

15p vielonmusk 21-01-2022 25 0   Download

The mRNA transcription of inflammation-related genes and cell cycle-associated genes decreased or delayed. The protein expressions of proliferation-related marker PCNA and proliferationassociated signaling pathway components JNK1, NF-κB and STAT3 reduced or retarded. There was stronger activation of proapoptotic proteins caspase-3, caspase-8 and BAX in the IL-1R1 KO mice at different time points (p < 0.05 or p < 0.01). IL-1R1 KO reduced inflammation and caused impaired liver regeneration after 2/3 partial hepatectomy in aged mice.

10p thiencuuchu 27-11-2021 9 1   Download

The osteogenic differentiation markers BMP2, BMP4, COL1A1, OPN, OCN and PF4 evaluated using RT-PCR. The tumor dimensions in the hMSCs group were significantly higher than those of the remaining groups (p < 0.01). The number of metastatic foci in the BMP2+hMSCs group was significantly lower than those of the other groups (p < 0.01). The current results showed that the intraperitoneal route could be efficiently used for targeting hMSCs to the tumoral tissues for effective BMP2 delivery.

13p thiencuuchu 27-11-2021 15 1   Download

Precision medicine promises to improve both the efficacy and safety of therapeutic products by better informing why some patients respond well to a drug, and some experience adverse reactions, while others do not. Pharmacogenomics is a key component of precision medicine and can be utilized to select optimal doses for patients, more precisely identify individuals who will respond to a treatment and avoid serious drug-related toxicities.

5p caothientrangnguyen 09-05-2020 11 2   Download

In this study, a total of sixteen RAPD primers were used for evaluation of the genetic diversity of eight H. serrata samples collected from different locations of Sa Pa and Da Lat. Overall, sixteen markers generated a total of 70 fragments in 8 collected samples of H. serrata. Of seventy generated fragments, 44 were found to be polymorphic.

6p shiwo_ding7 05-06-2019 22 1   Download

Trong nghiên cứu này, TBT được xử lý cùng các cytokine TNF-α, INF-ϒ, IL-2 và IL-10, tế bào sau khi thu hoạch được xác định sự phosphoryl hóa của protein STAT-1 và STAT-3, nồng độ TNF-α trong môi trường dịch huyền phù và số lượng tế bào phản ứng dương tính với các marker Annexin V và caspase 3.

8p shiwo_ding7 05-06-2019 36 1   Download

In this paper the individual markers (COI and 18S rRNA) were successfully used to identify some sponge taxa at the species level. The obtained results showed the congruence of molecular taxonomy using two independent markers. However, our study showed that a combination of the two markers provided more information and supported better for sponge identification.

10p shiwo_ding7 05-06-2019 32 3   Download

Human glandular kallikrein 2 (hK2) is a trypsin-like serine protease expressed predominantly in the prostate epithelium. Recently, hK2 has proven to be a useful marker that can be used in combination with prostate specific antigen for screening and diagnosis of prostate cancer. The cleavage by hK2 of certain substrates in the proteolytic cascade suggest that the kallikrein may be involved in prostate cancer development; however, there has been very little other progress toward its biochemical characterization or elucidation of its true physiological role.

8p system191 01-06-2013 44 2   Download

Diagnostic tests by molecular biology is made for studying the relations among Fusarium species for linking production of proteins, degree of relationship and occurrence of malformation. Determination of proteins for isolates causing-disease by SDS-PAGE explained there’s specific band for each fungus and there are common bands among some isolates of fungi. Since, band with MW 30 KDa represented only in F. proliferatum and F. oxysporum and F. subgluti-nans respectively. This band considered as specific band for these isolates, which released high patho-genisity effect.

7p zingzing09 24-04-2013 57 3   Download

We isolated a cholesterol-enriched membrane subpopulation from the so-called lipid raft fractions of Jurkat T-cells by taking advantage of its selective binding to a cholesterol-binding probe, BCh. The BCh-bound mem-brane subpopulation has a much higher cholesterol⁄phospholipid (C⁄P) molar ratio (
1.0) than the BCh-unbound population in raft fractions (
0.3). It contains not only the raft markers GM1 and flotillin, but also some T-cell receptor (TCR) signalling molecules, including Lck, Fyn and LAT. ...

10p fptmusic 12-04-2013 45 3   Download

Human glutamate carboxypeptidase II (GCPII) is a co-catalytic metallopeptidase and its putative catalytic domain is homologous to the aminopeptidases fromVibrio proteolyticus and Streptomyces griseus.In humans, the enzyme is expressed predominantly in the nervous system and theprostate.Theprostate form, termedprostate-specific membraneantigen, is overexpressed inprostate cancer and is used as a diagnostic marker of the disease.II

9p dell39 03-04-2013 39 4   Download

The P2X7receptor has recently been described as a marker for lung alveo-lar epithelial type I cells. Here, we demonstrate both the expression of P2X7 protein and its partition into lipid rafts in the mouse lung alveolar epithelial cell line E10.

13p galaxyss3 19-03-2013 27 4   Download

The activity of NTPDase (EC 3.6.1.5, apyrase, CD39) was verified in plate-lets from patients with increasing cholesterol levels. A possible association between cholesterol levels and inflammatory markers, such as oxidized low-density lipoprotein, highly sensitive C-reactive protein and oxidized low-density lipoprotein autoantibodies, was also investigated.

8p galaxyss3 19-03-2013 46 4   Download

The present study aimed to determine the role of Kupffer cells (KCs) in cytochrome P450 (CYP) isozyme activity and the expression of its gene during polymicrobial sepsis. For ablation of KCs, rats were pretreated with gadolinium chloride (GdCl3 ) at 48 and 24 h before cecal ligation and punc-ture (CLP). The depletion of KCs was confirmed by measuring the mRNA level of the KC marker gene CD163.

11p cosis54 05-01-2013 42 4   Download

Galectins are involved in many cellular processes due to their ability to bind carbohydrates. Understanding their functions has shown the necessity for potent and specific galectin inhibitors. Human galectin-7 (hGal-7), in particular, has been highlighted as an important marker in many types of cancer by either inhibiting or promoting tumour growth.

10p cosis54 08-12-2012 26 2   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Exploring ethical considerations for the use of biological and physiological markers in population-based surveys in less developed countries

7p panasonic04 19-12-2011 82 5   Download

Muralidhar Metta1, Sriramana Kanginakudru2, Narasimharao Gudiseva1, Javaregowda Nagaraju2 Addresses: 1Department of Animal Genetics and Breeding, College of Veterinary Science, A NG R Agricultural University, Hyderabad 500 030, India. 2Centre for DNA Fingerprinting and Diagnostics, ECIL Road, Nacharam, Hyderabad 500 076, India. Correspondence: Jawaregowda Nagaraju. E-mail: jnagaraju@cdfd.org.in reviews reports Posted: 4 March 2004 Genome Biology 2004, 5:P8 The electronic version of this article is the complete one and can be found online at http://genomebiology.

0p thulanh21 15-11-2011 48 1   Download

The caveolin gene family has three members in vertebrates: caveolin-1, caveolin-2, and caveolin-3. So far, most caveolin-related research has been conducted in mammals, but the proteins have also been found in other animals, including Xenopus laevis, Fugu rubripes, and Caenorhabditis elegans. Caveolins can serve as protein markers of caveolae (‘little caves’), invaginations in the plasma membrane 50-100 nanometers in

0p thulanh21 15-11-2011 51 2   Download

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Breeding value estimation with incomplete marker data

0p toshiba20 15-11-2011 47 4   Download

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Assignment of PCR markers to river buffalo chromosomes

0p toshiba20 15-11-2011 43 4   Download