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Biotransformation of xenobiotics

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  • The seventh edition of Casarett and Doull’s Toxicology: The Basic Science of Poisons, as the previous six, is meant to serve primarily as a text for, or an adjunct to, graduate courses in toxicology. Because the six previous editions have been widely used in courses in environmental health and related areas, an attempt has been made to maintain those characteristics that make it useful to scientists from other disciplines.

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  • In order to understand the roles of the epoxide hydrolases (EHs) in xenobiotic biotransformation in insects, we exam-ined the induction of EHs by exogenous compounds in Drosophila melangasterthird instar larvae. Among the chemicals tested, clofibrate, a phenoxyacetate hypolipider-mics drug, increased EH activity towardscis-stilbene oxide approximately twofold in larval whole-body homogenates. The same dose of clofibrate also induced glutathione S-transferase activity.

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