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Blood-borne viral

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  • Forty years ago, just prior to the discovery of the hepatitis B surface antigen, the concept that chronic liver disease could be a sequel to infection by any agent of acute viral hepatitis was controversial and hotly debated. With the development of specific and sensitive serologic and virologic markers of infection by the bloodborne and enterically transmitted hepatitis viruses, the linkage of the former agents with chronic hepatitis, cirrhosis, end-stage liver disease, and hepatocellular carcinoma was established beyond doubt....

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